Metaphase-II oocyte competence is unlinked to the gonadotrophins used for ovarian stimulation: a matched case–control study in women of advanced maternal age

Vaiarelli, Alberto; Cimadomo, Danilo; Scarafia, Carlotta; Innocenti, Federica; Amendola, Maria Giulia; Fabozzi, Gemma; Casarini, Livio; Conforti, Alessandro; Alviggi, Carlo; Gennarelli, Gianluca; Benedetto, Chiara; Guido, Maurizio; Borini, Andrea; Rienzi, Laura; Ubaldi, Filippo Maria

doi:10.1007/s10815-022-02684-w

Cited by 7 publications

(3 citation statements)

References 61 publications

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“…During OS, exogenous LH might play a relevant role in counteracting age-dependent decrease in oocyte quality. This effect is more evident in women between 35 and 40 years of age [51] and apparently not related to the rate of aneuploidies [50], suggesting the involvement of cytoplasmic-dependent mechanisms.…”

Section: The Relevance Of Os In Artmentioning

confidence: 83%

“…For this reason, the impact of the gonadotrophins used for OS on oocyte competence remains controversial. In a recent study, Vaiarelli and colleagues reported that MII oocyte competence is unlinked to the gonadotrophins used for OS [50]. More specifically, at least in advanced maternal age, the OS regimen does not seem to affect the euploid blastocyst rate per MII oocyte.…”

Section: The Relevance Of Os In Artmentioning

confidence: 99%

“…More specifically, at least in advanced maternal age, the OS regimen does not seem to affect the euploid blastocyst rate per MII oocyte. Conversely, two recent meta-analyses seem to support the hypothesis that supplementation with recombinant human LH (r-hLH) improves the outcome of IVF independently of oocyte yield [50][51][52]. In particular, LH supplementation significantly increases the clinical pregnancy rate in women between 35 and 40 years of age [52].…”

Section: The Relevance Of Os In Artmentioning

confidence: 99%

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Exploring the Impact of Controlled Ovarian Stimulation and Non-Invasive Oocyte Assessment in ART Treatments

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Invasive and noninvasive features are normally applied to select developmentally competent oocytes and embryos that can increase the take-home baby rates in assisted reproductive technology. The noninvasive approach mainly applied to determine oocyte and embryo competence has been, since the early days of IVF, the morphological evaluation of the mature cumulus-oocyte complex at the time of pickup, first polar body, zona pellucida thickness, perivitelline space and cytoplasm appearance. Morphological evaluation of oocyte quality is one of the options used to predict successful fertilization, early embryo development, uterine implantation and the capacity of an embryo to generate a healthy pregnancy to term. Thus, this paper aims to provide an analytical revision of the current literature relating to the correlation between ovarian stimulation procedures and oocyte/embryo quality. In detail, several aspects of oocyte quality such as morphological features, oocyte competence and its surrounding environment will be discussed. In addition, the main noninvasive features as well as novel approaches to biomechanical parameters of oocytes that might be correlated with the competence of embryos to produce a healthy pregnancy and live birth will be illustrated.

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Section: The Relevance Of Os In Artmentioning

confidence: 83%

Section: The Relevance Of Os In Artmentioning

confidence: 99%