Metaphyseal osteopathy in a British Shorthair cat

Adagra, Carl; Spielman, Derek; Adagra, Angela; Foster, Darren

doi:10.1177/1098612x14536422

Cited by 7 publications

(11 citation statements)

References 9 publications

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“…The first description of metaphyseal osteopathy in a cat has been recently published, while our report was under revision (14). Our case report has several differences and some similarities with this previous case.…”

Section: Discussionsupporting

confidence: 57%

“…Treatment consists of supportive care that includes administration of intravenous fluids, nutritional assistance, analgesics, corticosteroids, nonsteroidal anti-inflammatory drugs and antibiotics in dogs with bacteraemia (3,(11)(12)(13). The first case report of metaphyseal osteopathy in a British Shorthair cat was recently described (14). The aim of this report was to describe the clinical features, radiographic lesions, medical treatment, and outcome in two Domestic Shorthair sibling kittens with a growth plate disturbance that resembled the metaphyseal osteopathy reported in dogs and in the British Shorthair cat.…”

Section: Introductionmentioning

confidence: 99%

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Metaphyseal osteopathy-like disease in two sibling kittens

Pantaleo¹,

D’Ettorre²,

Caldín³

et al. 2016

Vet Comp Orthop Traumatol

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Metaphyseal osteopathy-like disease in two sibling kittens

Pantaleo¹,

D’Ettorre²,

Caldín³

et al. 2016

Vet Comp Orthop Traumatol

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“…Aumento de volume marcado nos membros afetados é um relato frequente nos casos de osteopatia hipertrófica. Ele pode estar acompanhado por dores e claudicação progressiva, que não foram relatados neste caso [1,9]. Embora os ossos longos dos membros pélvicos sejam frequentemente os mais afetados [8], neste gato as lesões eram mais marcadas nos membros torácicos, incluindo falanges.…”

Section: Discussionunclassified

“…Neste, foi sugerido que algum mecanismo hormonal estaria envolvido na patogenia da OH idiopática. Nos casos de OH decorrentes de doença primária, o tratamento da lesão inicial resulta na diminuição dos mecanismos envolvidos e, consequentemente, em regressão das lesões ósseas e cura do paciente [1,[9][10][11]; desse modo, seria pouco provável que esses mecanismos estivessem envolvidos na forma idiopática.…”

Section: Discussionunclassified

Hypertrophic Osteopathy in a Cat

Guizelini¹,

Mattei²,

Pupin³

et al. 2019

Acta Scientiae. Vet.

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Background: Hypertrophic osteopathy (OH) is a syndrome characterized by progressive bilateral periosteal bone neoformation that mainly affects the thoracic and pelvic limb bones' metaphyses and diaphyses. In most cases, it is secondary to a chronic primary lesion located in the thoracic cavity but can be associated with an abdominal injury that has already been occurred. The occurrence of this condition without being associated with a primary lesion is considered infrequent in animals. The purpose of this report was to describe a case of idiopathic hypertrophic osteopathy in a cat with a description of clinical signs and radiographic and anatomopathological findings. Case: A male adult cat was brought to the veterinarian with an initial observation by the owner of four limbs' volume increase, apathy, and reluctance to move. Upon clinical examination, the animal presented dehydration, mucosal hyperemia, hyperthermia, and bilateral edema of the thoracic and pelvic limbs. Based on the radiographic examination, a periosteal reaction with palisade-like appearance was found in the metacarpals, radios, ulna, humerus, scapulae, tibias, and fibulae. There were no significant changes in additional exams. Due to poor prognosis, the cat was euthanized and referred for necropsy and histopathological examination. All organs were examined both macroscopically and microscopically. Fragments were fixed in 10% formalin and routinely processed for histological slides with hematoxylin-eosin and Masson's trichrome, and limb bones that were not fixed in formalin were macerated. Lesions were observed only in the thoracic and pelvic limbs. Macroscopically, there was a diffuse, regular, slightly firm volume increase, covered by abundant gelatinous whitish tissue. The periosteal bone neoformations were characterized by numerous papillary projections distributed throughout the phalanges, radius, ulna, humerus, scapulae, tibia and fibulae. Histologically, the original bone matrix was surrounded by lightly organized eosinophilic material in bundles. Young bone matrix-formed trabeculae perpendicular to the original bone matrix, projecting into the mature bone tissue, was attached to the cortical layer. Discussion: The hypertrophic osteopathy diagnosis was based on clinical signs, radiographic examinations, and anatomopathological findings. Although the long bones of the pelvic limbs are often the most affected, the lesions were more marked in the thoracic limbs in this cat. The presumptive diagnosis was made through radiographic examination. Radiography is considered a very useful diagnostic method in animals suffering from this condition. Histological changes are compatible with persistent phases of hypertrophic osteopathy resulting from the action of osteoclasts and osteoblasts, with osteoid matrix deposition in the existing cortical bone. Since this cat didn't present macroscopic and microscopic alterations beyond the bone lesions, it was not possible to attribute them to a primary cause. For this reason, osteopathy was considered idiopath...

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“…Nutritional, infectious, vaccine-associated, and congenital causes have been implicated in the development of this disease; however, the exact pathogenesis remains unknown [3][4][5][6][7][8][9]. The disease has been well documented in domestic canines (Canis lupus familiaris), and there have also been reports of the disease in domestic cats (Felis domesticus) and Iberian lynx (Lynx pardinus) [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Hypertrophic Osteodystrophy in Two Red Wolf (Canis rufus) Pups

Gjeltema

MacLean

Cohen

et al. 2015

Case Reports in Veterinary Medicine

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A 6-month-old red wolf (Canis rufus) pup presented for evaluation of progressive thoracic and pelvic limb lameness, joint swelling, and decreased body condition. Radiographic evaluation revealed medullary sclerosis centered at the metaphyses of multiple long bones, well-defined irregular periosteal proliferation, and ill-defined lucent zones paralleling the physes, consistent with hypertrophic osteodystrophy (HOD). Biopsies of affected bone revealed medullary fibrosis and new bone formation. The pup improved following treatment with nonsteroidal anti-inflammatories, opioids, and supportive care over the course of 4 weeks. Metaphyseal periosteal bone proliferation persisted until the animal was humanely euthanized several years later for poor quality of life associated with bilateral cranial cruciate ligament rupture. A second red wolf pup of 4.5 months of age presented for evaluation of lethargy, kyphotic posture, and swollen carpal and tarsal joints. Radiographs revealed bilateral medullary sclerosis and smooth periosteal reaction affecting multiple long bones, suggestive of HOD. Further diagnostics were not pursued in this case to confirm the diagnosis, and the clinical signs persisted for 4 weeks. In light of these two case reports, HOD should be recognized as a developmental orthopedic disease in growing red wolves.

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Metaphyseal osteopathy in a British Shorthair cat

Cited by 7 publications

References 9 publications

Metaphyseal osteopathy-like disease in two sibling kittens

Metaphyseal osteopathy-like disease in two sibling kittens

Hypertrophic Osteopathy in a Cat

Hypertrophic Osteodystrophy in Two Red Wolf (Canis rufus) Pups

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