Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature

Mituś, Jerzy; Sas-Korczyńska, Beata; Kruczak, Anna; Jasiówka, Marek; Ryś, Janusz

doi:10.5114/aoms.2016.62917

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…ese studies showed that MBC was more likely to recur than TNBC and that more patients died of MBC than TNBC. In multivariate analysis, the local recurrence risk of MBC is about twice that of TNBC, and the DSS and overall survival of MBC are worse than TNBC [16][17][18][19]. We followed 37 MBC patients, 33 of them were able to collect complete information, and 1 of them was in stage IV at the time of diagnosis with multiple bone metastases.…”

Section: Discussionmentioning

confidence: 99%

Differences of Clinicopathological Features between Metaplastic Breast Carcinoma and Nonspecific Invasive Breast Carcinoma and Prognostic Profile of Metaplastic Breast Carcinoma

Qiu

Chen

et al. 2022

The Breast Journal

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Introduction. Metaplastic breast carcinoma is a rare special type of breast cancer, which has distinguished clinical characteristics. We aimed to evaluate the clinicopathological features of metaplastic breast carcinoma compared with nonspecific invasive breast carcinoma and study the prognosis of metaplastic breast carcinoma. Methods. We reviewed metaplastic breast carcinoma cases (n = 37) from January 2000 to December 2021 and nonspecific invasive breast carcinoma cases (n = 433) from January 2019 to December 2020 extracted from our institution retrospectively. The following variables were recorded, including the patients’ general information, complications, T stage, expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, molecular subtyping, lymph node status, skin or chest wall involvement, vessel carcinoma embolus, therapy modality (surgical treatments, chemotherapy, and radiotherapy), and survival. Results. Patients with metaplastic breast carcinoma had more advanced disease than patients with nonspecific invasive breast carcinoma (T stage: P = 0.0011 ). A greater proportion of metaplastic breast carcinoma presented with triple-negative breast cancer than nonspecific invasive breast carcinoma (79.41% vs. 12.47%, P ≤ 0.001 ). Our study showed that the skin or chest wall invasion was more frequent in metaplastic breast carcinoma patients (11.76% vs. 1.62%, P = 0.005 ). The 5-year survival rate for metaplastic breast carcinoma patients was 57.66% (95% CI: 0.3195∼0.7667). No local recurrence was observed while distant metastasis occurred in 33.33% of patients with metaplastic breast carcinoma. Death due to disease occurred in 24.24% of patients with metaplastic breast carcinoma. Conclusion. The majority of metaplastic breast carcinoma patients had more advanced disease and triple-negative disease than nonspecific invasive breast carcinoma patients. Also, metaplastic breast carcinoma patients had frequent skin or chest wall invasion and a high rate of distant metastasis and mortality.

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Section: Discussionmentioning

confidence: 99%

Differences of Clinicopathological Features between Metaplastic Breast Carcinoma and Nonspecific Invasive Breast Carcinoma and Prognostic Profile of Metaplastic Breast Carcinoma

Qiu

Chen

et al. 2022

The Breast Journal

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“…Conversely, the region of DCIS is not easily distinguished in the microelastogram and is more readily identified in the OCT image, demonstrating the complementarity of OCT and QME. Figure 7 presents results from a mastectomy specimen containing invasive metaplastic spindle cell carcinoma (IMSCC), which is a very rare breast cancer type, accounting for 0.1-1% of all breast carcinomas [33,34]. Figures 7(a) and 7(b) present photographs of the scanned area acquired with the probe and the corresponding histology image at a depth of ~100 µm from the tissue surface, respectively.…”

Section: Handheld Qme On Breast Tissue Specimensmentioning

confidence: 99%

Handheld probe for quantitative micro-elastography

Fang¹,

Krajancich²,

Chin³

et al. 2019

Biomed. Opt. Express

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Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulky, labbased imaging systems. A compact, handheld imaging probe would accelerate clinical translation, however, to date, this had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user's hand. In this paper, we present a proofof-concept, handheld quantitative micro-elastography (QME) probe capable of scanning a 6 × 6 × 1 mm volume of tissue in 3.4 seconds. This handheld probe is enabled by a novel QME acquisition protocol that incorporates a custom bidirectional scan pattern driving a microelectromechanical system (MEMS) scanner, synchronized with the sample deformation induced by an annular PZT actuator. The custom scan pattern reduces the total acquisition time and the time difference between B-scans used to generate displacement maps, minimizing the impact of motion artifact. We test the feasibility of the handheld QME probe on a tissue-mimicking silicone phantom, demonstrating comparable image quality to a benchmounted setup. In addition, we present the first handheld QME scans performed on human breast tissue specimens. For each specimen, quantitative micro-elastograms are co-registered with, and validated by, histology, demonstrating the ability to distinguish stiff cancerous tissue from surrounding soft benign tissue.

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“…Triple-negative breast cancer is diagnosed in 12–17% of all breast cancer cases. As the TNBC cells are frequently relatively heterogeneous and poorly differentiated, this cancer type is thought to run an aggressive course with rapid recurrences [ 4 ] and common development of distant metastases [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical evaluation of osteopontin expression in triple-negative breast cancer

et al. 2020

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IntroductionTriple-negative breast cancer (TNBC) is associated with lack of expression of estrogen and progesterone receptors and HER2 and is the subgroup of breast cancers with the worst prognosis. Osteopontin is a phosphorylated glycoprotein whose overexpression may occur in pathological states such as cancers. The main purpose of our study was to evaluate the immunohistochemical expression of osteopontin in connection with the analysis of recognized clinical and pathological prognostic factors in primary sites of TNBC with and without lymph node metastases.Material and methodsThe immunohistochemical evaluation of osteopontin expression in 35 women with TNBC, chosen from a group of 726 patients, was performed. The material came from the excisional biopsies of primary breast cancers and total mastectomies.ResultsAll patients showed expression of osteopontin, in most cases the expression of osteopontin rated at [+] (57.1%) and [++] (42.9%). Our study analyzed the relationship between the expression of osteopontin and traditional prognostic markers, such as the tumor grade, size, and lymph node involvement. We found a strong relationship only between the expression of osteopontin and the presence of lymph node metastases (p ≤ 0.0001). 93% of patients for whom the expression of osteopontin was determined at [++] had metastasis to lymph nodes and, for comparison, only 15% of women for whom the expression of osteopontin was rated at [+] showed the presence of metastases in the lymphatic nodes.ConclusionsThere is a correlation between osteopontin expression and the presence of lymph node metastases in TNBC, suggesting that osteopontin plays an important role in the invasiveness of TNBC.

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Metaplastic breast cancer with rapidly progressive recurrence in a young woman: case report and review of the literature

Cited by 6 publications

References 25 publications

Differences of Clinicopathological Features between Metaplastic Breast Carcinoma and Nonspecific Invasive Breast Carcinoma and Prognostic Profile of Metaplastic Breast Carcinoma

Differences of Clinicopathological Features between Metaplastic Breast Carcinoma and Nonspecific Invasive Breast Carcinoma and Prognostic Profile of Metaplastic Breast Carcinoma

Handheld probe for quantitative micro-elastography

Immunohistochemical evaluation of osteopontin expression in triple-negative breast cancer

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