Metaplastic Papillary Tumor of the Fallopian Tube

Keeney, Gary L.; Thrasher, Thais V.

doi:10.1097/00004347-198803000-00009

Cited by 20 publications

(9 citation statements)

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“…5 Mucinous metaplasia of the tubal epithelium has been described by some authors. 1,2,4,5,7,8,10,13,14 The results of the current study indicate that SMMN-FGT might be a consequence of pyloric gland metaplasia. PGM of the uterine cervix is usually associated with endocervical glandular hyperplasia 15 and is interchangeably called LEGH, which was first described by Nucci et al 16 Although LEGH ⁄ PGM is considered to be a benign condition, 16,17 recent studies have demonstrated that it can be associated with adenocarcinomas, 18,19 emphasizing its significance as a possible precursor of adenocarcinoma.…”

Section: Discussionmentioning

confidence: 63%

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Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia

et al. 2009

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Section: Discussionmentioning

confidence: 63%

“…In two other cases in the series, benign‐looking foci of mucinous epithelium lined the fallopian tube 5 . Mucinous metaplasia of the tubal epithelium has been described by some authors 1,2,4,5,7,8,10,13,14 …”

Section: Discussionmentioning

confidence: 88%

Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia

et al. 2009

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“…MPT is usually confined to the mucosa and does not show moderate-to-severe cytological atypia or coagulative tumor cell necrosis. To the best of our knowledge, 12 cases of tubal MPT have been reported in the English literature (7)(8)(9)(10)(11)(12)(13)(14). Table II summarizes the clinical features of 12 patients diagnosed with tubal MPT.…”

Section: C: Mpt Cells (Right Two-thirds) Displayed Patchy P16 Expressmentioning

confidence: 99%

“…Metaplastic papillary tumor (MPT) is an extremely rare lesion of the fallopian tube. Only 11 cases of tubal MPT have been documented in the previous literature to date (7)(8)(9)(10)(11)(12)(13)(14). Tubal MPT has been reported to be closely related to pregnancy because it is found upon examination of fallopian tube segments removed for sterilization in the immediate postpartum period.…”

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confidence: 99%

Clinicopathological Characteristics of Metaplastic Papillary Tumor of the Fallopian Tube

Jang

Sung

Kim

et al. 2017

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Metaplastic papillary tumor (MPT) of the fallopian tube is a very uncommon lesion, displaying papillary growth of bland-appearing cells with abundant, eosinophilic cytoplasm and mucinous metaplasia. It is difficult for pathologists to determine whether to categorize this lesion as a metaplastic proliferative lesion or a true neoplasm. We recently experienced a case of tubal MPT and initiated a comprehensive review of previously published cases with thorough analysis of clinicopathological characteristics. MPT is typically related to pregnancy, but we describe the first case of pregnancy-unrelated, incidentally detected tubal MPT in a 51-year-old woman who underwent surgery for endometrial cancer. The MPT consisted of small papillary formations with epithelium consisting of nonciliated, columnar cells with abundant eosinophilic cytoplasm arranged as either a single layer or pseudostratified layer. The stroma had a myxoid appearance. Intraluminal and extracellular mucin and floating papillary tufts were observed. Nuclei of the epithelial lining cells were centrally located, rounded or oval, and displayed intranuclear pseudoinclusions or grooves. The MPT cells were positive for paired box 8, epithelial membrane antigen, and cytokeratin. Interestingly, Wilms tumor 1 (WT1) protein was localized within the cytoplasm of MPT cells. Furthermore, the MPT cells did not express phosphatase and tensin homolog deleted on chromosome 10 (PTEN). In summary, MPT of the fallopian tube is a very unusual, distinctive entity displaying unique histopathological features and immunophenotype. Our observation of cytoplasmic WT1 expression and loss of PTEN expression in tubal MPT suggests its neoplastic nature and raises the possibility of WT1 or PTEN involvement in the development of MPT.

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“…2 Ultrastructural study done by Keeney and Thrasher showed abundant parallel wavy filaments. 12 Categorisation of this lesion as metaplastic or neoplastic is controversial though it is generally considered to be non-neoplastic. 11,13 Moore and Enterline, in order to find out significance of proliferative epithelial lesions of the fallopian tube studied the entire tube (unilateral/bilateral) in 124 cases.…”

Section: Case Notementioning

confidence: 99%

Fallopian Tube Papilloma – Case Report of a Rare Tumor

Narasimhaiah

Ansari

Haritwal

et al. 2015

Kathmandu Univ. Med. J.

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Fallopian tube neoplasms are rare. We report a rare case of fallopian tube papilloma discovered incidentally in a 45 year old female, operated for procidentia. Right tube was dilated at the infundibular region, with friable grey white tissue in the lumen. Microscopy showed delicate branching papillae lined by a single layer of epithelium resembling tubal lining. There were no features to suggest a reactive hyperplasia in response to inflammation or of aggressive behaviour. KEY WORDSEpithelial lesions, fallopian tube papilloma, metaplastic papillary tumor, proliferative

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Metaplastic Papillary Tumor of the Fallopian Tube

Cited by 20 publications

References 0 publications

Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia

Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia

Clinicopathological Characteristics of Metaplastic Papillary Tumor of the Fallopian Tube

Fallopian Tube Papilloma – Case Report of a Rare Tumor

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