Métastases choroïdiennes révélatrices d’un adénocarcinome bronchique et involuant sous chimiothérapie

Battikh, M.H.; Yahia, Salim Ben; Sayah, M M Ben; Maatallah, A; Joobeur, S.; Rouatbi, N.; Khairallah, Moncef; Kamel, A. El

doi:10.1016/s0761-8417(04)72149-5

Cited by 16 publications

(7 citation statements)

References 9 publications

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“…[ 39 ] Regression of choroidal metastasis from breast and lung carcinoma after systemic chemotherapy has been noted. [ 40 41 42 43 ] In a study of 4 patients with choroidal metastasis treated with systemic chemotherapy alone, tumor regression occurred in 3 patients. [ 44 ]…”

Section: Systemic Treatmentmentioning

confidence: 99%

Choroidal metastases: Origin, features, and therapy

Arepalli¹,

Kaliki²,

Shields³

2015

Indian J Ophthalmol

147

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The choroid is the most common ocular site for metastatic disease, owing to abundant vascular supply. The primary cancers that most commonly lead to choroidal metastases include breast cancer (40-47%) and lung cancer (21-29%). Bilateral, multifocal metastases are most often secondary to breast cancer, whereas unilateral, unifocal metastasis are more commonly found with lung cancer. The treatment of choroidal metastasis depends on the systemic status of the patient and number, location, and laterality of the choroidal tumors. Treatment options include observation in patients with poor systemic status or those with resolved or asymptomatic disease; systemic chemotherapy, immunotherapy, hormone therapy, or whole eye radiotherapy if the metastases are active, multifocal and bilateral; plaque radiotherapy, transpupillary radiotherapy, or photodynamic therapy for active, solitary metastasis; and enucleation for those with blind painful eye. A database search was performed on PubMed, using the terms “choroidal metastasis,” or “choroidal metastases,” in combination with terms such as “treatment,” “features,” or “diagnosis.” Relevant articles were extracted and reviewed.

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Section: Systemic Treatmentmentioning

confidence: 99%

Choroidal metastases: Origin, features, and therapy

Arepalli¹,

Kaliki²,

Shields³

2015

Indian J Ophthalmol

147

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“…It has been reported that systemic chemotherapy is efficacious for choroid metastases from non-small-cell lung cancer [11,12]. In our patient’s case, standard platinum doublet chemotherapy was used as the initial and primary treatment because our patient had other concurrent sites of metastatic disease that required simultaneous attention.…”

Section: Discussionmentioning

confidence: 98%

Choroid metastases revealing primary clear cell adenocarcinoma of the lung effectively treated with cisplatin and pemetrexed: a case report

et al. 2013

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IntroductionThe aim of the present report was to draw the attention of oncologists to the importance of prompt diagnosis of primary clear cell adenocarcinoma of the lung, which allows early initiation of treatment to maintain quality of life.Case presentationA 63-year-old Chinese woman initially presented to our facility with multifocal bilateral choroid metastatic lesions that were found to originate from a primary clear cell adenocarcinoma of the lung (T2bN2M1b, stage IV). A thorough ophthalmologic evaluation, study of our patient’s history, imaging studies and comprehensive immunohistochemical staining tests led to the diagnosis of this rare lung tumor.ConclusionsAlthough this uncommon cancer is unfortunately already at a late stage when choroid metastases develop, systemic chemotherapy alone is sufficient to preserve vision and gain control over the disease.

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“…However, the effect of treatment on ocular metastatic lesions has not been widely reported. A: Some case reports show that chemotherapy is efficient for choroidal metastasis from NSCLC [ 5 , 9 , 16 – 20 ], mostly related to adenocarcinoma [ 5 , 16 – 20 ]. Yalcinbayir et al [ 9 ] described a lung squamous cell carcinoma patient who received docetaxel/carboplatin combination chemotherapy, and the retinal metastatic lesion displayed marked regression without other specific ocular treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of ocular metastases from lung cancer is reported to be 0.1–7% in the global literature [ 1 – 3 ], with adenocarcinoma and small cell lung cancer accounting for the highest proportions of these cases [ 1 , 2 ]. The majority of cases involve metastasis to more than one other distal organ in addition to the eye [ 4 , 5 ]. However, lung squamous cell carcinoma with solitary symptomatic ocular metastasis as the initial manifestation that is managed by a multidisciplinary treatment (MDT) has never been reported before.…”

Section: Introductionmentioning

confidence: 99%

Lung squamous cell carcinoma with solitary ocular metastasis and its successful treatment with thoracic surgery and chemotherapy: an interesting and rare case report

et al. 2018

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BackgroundThe incidence of ocular metastasis from lung cancer is reported to be 0.1–7%, with adenocarcinoma and small cell lung cancer accounting for the highest proportions of these cases. The majority of cases involves metastasis to more than one other distal organ in addition to the eye. Here, we report for the first time, a case of lung squamous cell carcinoma with solitary symptomatic ocular metastasis as the initial manifestation that was managed by a multidisciplinary treatment (MDT).Case presentationA woman presented at the ophthalmology department of hospital with a 1-week history of left eye pain and blurred vision. Systemic examination led to the diagnosis of central lung cancer in the right lower lobe with ocular metastasis. After consultations with an MDT, including specialists from the surgery, internal medicine, ophthalmology, radiotherapy and imaging departments, the patient underwent surgery and chemotherapy. Her eye symptoms disappeared, and the ocular lesion was well controlled without any specific ocular treatment. The patient demonstrated a prolonged progression-free survival.ConclusionThis is the first report of a rare case with solitary ocular metastasis as the initial manifestation of lung squamous cell carcinoma. This rare patient was treated based on evidence-based medicine, indicating the importance of cooperation within an MDT. The successful treatment of this case was reported as a new therapeutic reference for clinicians who encounter similar cases in the future.

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Métastases choroïdiennes révélatrices d’un adénocarcinome bronchique et involuant sous chimiothérapie

Cited by 16 publications

References 9 publications

Choroidal metastases: Origin, features, and therapy

Choroidal metastases: Origin, features, and therapy

Choroid metastases revealing primary clear cell adenocarcinoma of the lung effectively treated with cisplatin and pemetrexed: a case report

Lung squamous cell carcinoma with solitary ocular metastasis and its successful treatment with thoracic surgery and chemotherapy: an interesting and rare case report

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