Metastases to the cavernous sinus from primary carcinoma of the larynx

Zahra, Mohammed K.; Tewfik, Hamed H.; McCabe, Brian F.

doi:10.1002/jso.2930310117

Cited by 15 publications

(7 citation statements)

References 3 publications

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“…Cancers with primary tumors outside of the head and neck have been shown to occasionally metastasize to the cavernous sinus, including carcinomas of the lung [ 16 ], colon [ 17 , 18 ], and liver [ 19 ]. Head and neck cancers have also been described to metastasize to the cavernous sinus, including squamous cell carcinomas with laryngeal primaries [ 20 ], papillary thyroid cancer [ 21 ], and facial tumors [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Cavernous sinus involvement in human papillomavirus associated oropharyngeal squamous cell carcinoma: Case report of an atypical site of distant metastasis

Forner

Wilke

Rigby

et al. 2018

Journal of Otolaryngology - Head & Neck Surgery

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BackgroundHPV-associated OSCC (HPV-OSCC) has been determined to be a distinct disease entity from non-HPV associated OSCC. Patients affected by HPV-OSCC generally have a more favourable prognosis, with improved rates of locoregional control and survival compared with their non-HPV counterparts. Despite this, HPV-OSCC has a similar rate of distant metastases. Interestingly, recent evidence has emerged that demonstrates more frequent atypical metastasis patterns when compared to non-HPV associated disease. To the best of our knowledge, this report describes the first case of a confirmed HPV-OSCC with distant metastasis to the cavernous sinus.Case PresentationA 62-year-old non-smoking male presented to the head and neck oncology clinic with a five-month history of enlarging right neck mass causing neck pain, dysphagia, and dysphonia. HPV-associated base of tongue squamous cell carcinoma (cT4aN2c) was diagnosed, and he was treated with primary chemoradiation. Shortly after treatment, he presented with progressive bilateral cranial nerve palsies including left cranial nerve III and right cranial nerve VI involvement. Imaging identified masses in the left cavernous sinus with extension of tumor into the sella and in the right cavernous sinus at the level of Dorello’s canal. Endoscopic Image Guided Transsphenoidal biopsy of the left sellar mass confirmed distant metastases from the previously treated HPV-OSCC primary to the cavernous sinus. The patient was palliated with carboplatin and paclitaxel.ConclusionThe presented report is the first documented case of confirmed HPV-associated oropharyngeal squamous cell carcinoma metastasizing to the cavernous sinus, and the only HPV confirmed head and neck cancer case to present with metastasis to the cavernous sinus and limited extracranial disease. This case demonstrates the importance of recognizing presentations of atypical metastasis that are possible in HPV-associated oropharyngeal cancer. Given the rarity of metastasis to this region, vigilance in follow up is instrumental in early identification and treatment for these patients.

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Section: Discussionmentioning

confidence: 99%

Cavernous sinus involvement in human papillomavirus associated oropharyngeal squamous cell carcinoma: Case report of an atypical site of distant metastasis

Forner

Wilke

Rigby

et al. 2018

Journal of Otolaryngology - Head & Neck Surgery

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“… 8 In contrast, only 11 cases are reported documenting cavernous sinus metastasis from laryngeal carcinoma, with a mean survival of 4.7 months. 9 , 10 , 11 , 12 , 13 , 14 , 15 Furthermore, given that the patient's MRI demonstrated perineural spread, a diagnosis of lymphoma could not be ruled out as it has also been shown to demonstrate this feature. 16 Primary cavernous sinus lymphoma is a rare entity with 8 cases described in the literature - however, these lesions are amenable to systemic chemotherapy and the prognosis of cavernous sinus lymphoma with treatment is far better than that of metastasis from colorectal carcinoma with an average survival greater than 18 months.…”

Section: Discussionmentioning

confidence: 99%

Cavernous sinus syndrome associated with metastatic colorectal cancer and perineural spread along the trigeminal nerve

Nassrallah

Sun

Guiot

et al. 2017

American Journal of Ophthalmology Case Reports

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PurposeWe report the case of a patient with cavernous sinus syndrome associated with biopsy-confirmed metastasis from colorectal cancer.ObservationsA patient known for laryngeal carcinoma and metastatic colorectal carcinoma presented with symptoms of left trigeminal neuralgia and progressive, near-complete ophthalmoplegia. Magnetic resonance imaging (MRI) revealed a mass in the left cavernous sinus, extending into Meckel's cave with perineural spread along the mandibular branch of the left trigeminal nerve. A transsphenoidal biopsy was performed and demonstrated metastatic colon adenocarcinoma. We review the existing literature on colorectal cancer associated cavernous sinus syndrome.Conclusions and importanceCavernous sinus metastasis from colorectal cancer is exceedingly rare. We report the second case of this entity with histopathologic confirmation, and the first case with concurrent perineural spread involving the trigeminal nerve. Cavernous sinus metastasis may represent a poor prognostic factor in colorectal cancer.

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“…Cavernous sinus metastases of laryngeal carcinomas are very rare (10)(11). These patients can have headache, diplopia, strabismus, visual disturbances and facial paralysis/paresthesia.…”

Section: Discussionmentioning

confidence: 99%

Laryngeal Carcinoma Presenting with Cavernous Sinus Metastasis

Köseoğlu¹,

İkincioğulları²,

Cetin³

et al. 2016

West Indian Med J

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Laryngeal carcinoma can metastasize to several locations among which neck is the most frequent. In this case report 53 years old patient who diagnosed with laryngeal carcinoma underwent total laryngectomy, total thyroidectomy and right radical neck dissection.Contralateral neck dissection was planned for three weeks later. On the third postoperative week the patient developed VI and VII cranial nerve paralysis. The patient was given palliative chemoradiotherapy however, one year after the primary diagnosis and three months after the cavernous sinus metastasis he died. Despite the fact that the metastasis of the laryngeal carcinoma to the cavernous sinus is very rare, it has a very unfavorable prognosis.

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Metastases to the cavernous sinus from primary carcinoma of the larynx

Abstract: Distant metastases from late stages of carcinoma of the vocal cords can occur. Such metastatic deposit can occur in unusual sites. In this report, we are presenting a patient with spread to the cavernous sinus. Radiation therapy was of palliative value.

Cited by 15 publications

References 3 publications

Cavernous sinus involvement in human papillomavirus associated oropharyngeal squamous cell carcinoma: Case report of an atypical site of distant metastasis

Cavernous sinus involvement in human papillomavirus associated oropharyngeal squamous cell carcinoma: Case report of an atypical site of distant metastasis

Cavernous sinus syndrome associated with metastatic colorectal cancer and perineural spread along the trigeminal nerve

Laryngeal Carcinoma Presenting with Cavernous Sinus Metastasis

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