Metastases to the uterine corpus from extragenital cancers. A clinicopathologic study of 63 cases

Kumar, Naveen; Hart, William R.

doi:10.1002/1097-0142(19821115)50:10<2163::aid-cncr2820501032>3.0.co;2-f

Cited by 269 publications

(183 citation statements)

References 7 publications

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“…Abnormal uterine bleeding is often the first presentation in women with uterine metastasis, with or without a history of malignancy (28,29,31). In a series of 52 non-gynecological cancer metastases within the uterine corpus reported by Kumar and Hart (31), the authors found that the endometrium was involved in only 36.5% of the cases.…”

Section: Clinical Presentationsmentioning

confidence: 83%

“…The metastases were almost always found in the myometrium, with or without endometrial involvement (96.2% of cases), suggesting that lymphatic and hematological spread, as well as direct intraluminal spread from the ovary through the Fallopian tube, represent possible underlying mechanisms. The authors also investigated the distribution of other metastases in autopsy cases with metastases to the uterine corpus from extragenital cancers, and found that all cases were positive for lymph node metastasis but lacked an ovarian metastasis in 35.0% of the cases (31). The majority of metastases to the uterine corpus are considered to be secondary to local lymphatic spread from a preceding ovarian metastasis, while spread is likely hematological when the ovaries are not affected (28,29,31,32).…”

Section: Characteristicsmentioning

confidence: 99%

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Metastatic gastric cancer to the female genital tract

Matsushita

Watanabe

Wakatsuki

2016

Molecular and Clinical Oncology

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Abstract. Metastases to the female genital tract from gastric cancer are rare, but they significantly worsen the prognosis of such patients. The potential routes for metastasis to the female genital tract from gastric cancer include hematogenous spread, lymphatic spread and surface implantation. The rate of lymphatic metastasis to the ovary from gastric cancer has been reported to be higher compared with that from colorectal cancer. Uterine or Fallopian tube metastases are usually secondary to ovarian metastases, which are typically identified prior to the detection of gastric cancer in half of all synchronous cases, with complaints of abdominal distention, pain, palpable mass, or abnormal uterine bleeding. The prognosis of patients with female genital tract metastases from gastric cancer is extremely poor, and is worse compared with that of other primary sites, such as the breast and colorectum. In the past, surgical intervention in such patients consisted mainly of palliative resection to relieve the symptoms associated with a sizeable pelvic mass. However, recent retrospective studies based on a relatively small number of patients have reported that surgical tumor debulking plus chemotherapy may improve the prognosis of patients with metastatic ovarian cancer originating from gastric cancer.

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Section: Clinical Presentationsmentioning

confidence: 83%

Section: Characteristicsmentioning

confidence: 99%

Metastatic gastric cancer to the female genital tract

Matsushita

Watanabe

Wakatsuki

2016

Molecular and Clinical Oncology

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“…The uterus is an unusual site for metastasis but a recent paper by Kumar & Hart (1982) reports on 63 extragenital neoplasms metastasising to the uterine corpus; of these 29 (42.9%) were breast carcinomas and, whilst they are not fully analysed with regard to histological type, two cases cited in some detail were respectively infiltrating lobular and signet ring carcinomas (which is often a variant of lobular carcinoma). In the first of these the pattern of infiltration of the endometrial stroma had suggested to the referring pathologist the possibility of endometrial stromal sarcoma or adenosarcoma.…”

Section: Uterusmentioning

confidence: 99%

A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast

Harris¹,

Howell²,

Chrissohou³

et al. 1984

Br J Cancer

339

185

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The metastatic sites of infiltrating duct (IDC) and infiltrating lobular carcinoma (ILC) have been compared using both clinical and autopsy data. The following statistically significant differences were found: Lung parenchymal metastases were more common in IDC. Bone trephine biopsies were more likely to be positive in ILC. Carcinomatous meningitis was associated almost exclusively with ILC. Peritoneal/retroperitoneal metastases of distinctive pattern occurred in ILC. There was often associated linitis plastica-like involvement of the stomach wall and diffuse infiltration of the uterus. Hydronephrosis was a common secondary phenomenon. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5

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“…To the best of our knowledge, there has only been 1 report on breast cancer that was detected from an initial diagnosis of a uterine metastasis, although it was not an apocrine carcinoma of the breast (Kumar and Hart 1982). In this case, breast cancer was discovered incidentally as a result of a detailed work-up after a positive result from uterine cancer screening.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, there has been only one report on breast cancer that was detected from an initial diagnosis of a uterine metastasis, although it was not an apocrine carcinoma of the breast (Kumar and Hart 1982).…”

mentioning

confidence: 99%

Incidental Detection of Breast Apocrine Carcinoma via Endometrial Cytology

Shiota

Kotani

Umemoto

et al. 2011

Tohoku J. Exp. Med.

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Breast apocrine carcinoma is a rare malignancy characterized histologically by a predominance of acidophilic tumor cells exhibiting apocrine metaplasia. Apocrine tumors represent only about 0.4% of all breast cancers. Many cases are diagnosed at stage I or II; thus, the prognosis is better than that for other types of breast cancer. Here we present a 57-year-old female patient with primary apocrine breast carcinoma that was incidentally discovered by endometrial cytology. The patient had undergone routine uterine cancer screening at the age of 56 with resulting positive endometrial cytology. Subsequent histological examination of an endometrial biopsy revealed suspected metastatic uterine adenocarcinoma. Further evaluation revealed a 3-cm mass in the left breast, which was histopathologically diagnosed as breast cancer. Dual procedures were performed at the departments of gynecology and breast surgery. The patient underwent a modified radical mastectomy of the left breast and left axillary lymph node dissection. Laparotomy revealed multiple adhesions throughout the peritoneal cavity that suggested invasive metastatic cancer, and a right adnexectomy was performed. Histopathological examination of the resected left breast and right ovary tissues revealed apocrine carcinoma. Thus, stage IV breast cancer was diagnosed. The patient finished 6 cycles of paclitaxel and is now under observation on an outpatient basis. In this patient, breast cancer was discovered incidentally through a detailed work-up after a positive result of endometrial cytology. Uterine cancer screening has the potential, although rare, to detect metastatic cancer originating elsewhere. This should be taken into consideration during the work-up due to positive endometrial cytology.Keywords: apocrine carcinoma; breast cancer; endometrial cytology; metastasis; uterine cancer screening Tohoku J. Exp. Med., 2011, 225 (4), 235-237. © 2011 Tohoku University Medical Press Apocrine carcinoma of the breast is a rare type of breast cancer. It is estimated to represent 0.4% of all breast cancers (Mossler et al. 1980). Many of the cases are diagnosed at stage I or II; thus the prognosis is thought to be better than that for other breast cancers (Gădăleanu and Galatâr 1986). The 10-year survival rate has been reported to be 52% (d'Amore et al. 1988).Metastatic foci of breast cancers are often detected in the lungs, liver, bones, or ovaries. To the best of our knowledge, there has been only one report on breast cancer that was detected from an initial diagnosis of a uterine metastasis, although it was not an apocrine carcinoma of the breast (Kumar and Hart 1982).Here, we report a patient with apocrine carcinoma of the breast with uterine metastasis that was diagnosed through evaluation of the patient because of positive endometrial cytology. PatientA 57-year-old woman, gravid 2 para 2, postmenopausal for 6 years, with no remarkable past medical history or family history, had a diagnosis of negative for intraepithelial lesion or malignancy (NILM) with cervical co...

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Metastases to the uterine corpus from extragenital cancers. A clinicopathologic study of 63 cases

Cited by 269 publications

References 7 publications

Metastatic gastric cancer to the female genital tract

Metastatic gastric cancer to the female genital tract

A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast

Incidental Detection of Breast Apocrine Carcinoma via Endometrial Cytology

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