Metástasis cutáneas de cáncer de mama: 8 años de revisión en un centro de tercera complejidad

Bastard, Dolores Pilar; Bollea-Garlatti, M.L.; Belatti, Anahí Lorena; Puga, María Celeste; Hernandez, Maria; Mazzuoccolo, Luis Daniel

doi:10.1016/j.ad.2018.12.004

Cited by 9 publications

(10 citation statements)

References 13 publications

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“…La metástasis cutánea es el compromiso de la dermis o del tejido celular subcutáneo por una neoplasia maligna [1][2][3][4][5] , son también conocidas como cutánides 6 .…”

Section: Discussionunclassified

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Metástasis cutáneas en pacientes con cáncer de mama. Serie de casos

Dávila-Zablah¹,

Aguirre-González²,

Garza-Montemayor³

et al. 2023

ARM

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Introduction: Breast cancer is the most common malignant neoplasm in women; the most frequent sites of metastasis are to the bone, lung and liver and less common to the skin. The purpose of this case series is to review the clinical and imaging presentation of patients with skin metastases secondary to breast cancer. Method: Retrospective, crosssectional study. A review of the results of cutaneous metastases due to breast cancer was carried out in our institution over a period of 5 years; its clinical and imaging findings were analyzed. Our results are compared with that reported in the literature. Results: The prevalence of skin metastases was 0.6%, the age range was from 36 to 68 years. Most of our patients presented palpable nodularity. The most common ultrasound finding was multiple nodules with indistinct and avascular margins on color Doppler. The diagnosis was by ultrasound and biopsy. Conclusion: Cutaneous metastases due to breast cancer are rare, however it is extremely important for the radiologist to know this pathology for its diagnosis, in order to provide adequate treatment and reduce the mortality of the patient.

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“…La metástasis cutánea es el compromiso de la dermis o del tejido celular subcutáneo por una neoplasia maligna [1][2][3][4][5] , son también conocidas como cutánides 6 .…”

Section: Discussionunclassified

“…El intervalo de diagnóstico entre el tumor primario y las metástasis cutáneas es variable, en general suele ocurrir dentro de los tres años del diagnóstico, en algunos casos precede su diagnóstico 1,2,7-17 y en otros casos aparecen 10 años más tarde 1,6,17 , similar a lo encontrado en el presente estudio.…”

Section: Discussionunclassified

Metástasis cutáneas en pacientes con cáncer de mama. Serie de casos

Dávila-Zablah¹,

Aguirre-González²,

Garza-Montemayor³

et al. 2023

ARM

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“…Breast cancer metastases to the skin commonly present as nodules. However, they can appear as bullae, inflammatory carcinoma metastases (erysipelatoides, hemorrhagiectoides, and telangiectoides), or plaques [3][4][5]8,12]. 1 2…”

Section: Specific Tumor-associated Cutaneous Metastases Morphologiesmentioning

confidence: 99%

“…They are most frequently found on the skin of the ipsilateral affected breast. However, they can be located on the opposite breast skin, inframammary fold, periocular area, scalp, subungual region, and umbilicus [3][4][5]8,12].…”

Section: Specific Tumor-associated Cutaneous Metastases Morphologiesmentioning

confidence: 99%

“…Typically, when they do appear, it is in the setting of an oncology patient whose visceral malignancy is progressing. However, albeit less often, they may be either the initial presentation of malignancy in a previously cancer-free individual or the heralding sign of cancer recurrence in a patient whose malignancy had been in remission [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous Metastatic Cancer: Carcinoma Hemorrhagiectoides Presenting as the Shield Sign

Cohen¹,

Kurzrock²

2021

Cureus

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Cutaneous metastases can be either the initial presentation of an unsuspected internal neoplasm in a cancer-free individual, or the harbinger of recurrent malignancy in an oncology patient who had achieved remission of his cancer, or a sign of progressive disease in a cancer patient who is currently receiving antineoplastic treatment. The cutaneous presentation of skin metastases is pleomorphic and can mimic not only benign conditions and tumors of the skin but also infections and inflammation of the skin. Carcinoma erysipelatoides, carcinoma hemorrhagiectoides, and carcinoma telangiectoides are the three subtypes of inflammatory cutaneous metastatic cancer. The former masquerades as a cutaneous streptococcal infection whereas the latter mimics idiopathic telangiectasias. In contrast, the morphology of carcinoma hemorrhagiectoides is distinctive: it appears similar in shape to a medieval knight’s shield and its presence is referred to as a positive shield sign. To the best of our knowledge, carcinoma hemorrhagiectoides has been reported in four oncology patients whose skin metastases presented with the shield sign: two men with salivary duct carcinoma and two women with breast cancer. In conclusion, the shield sign may not only be a pathognomonic clinical feature of carcinoma hemorrhagiectoides but also reflect a common genomic aberration of these metastatic tumors.

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Predictors and outcomes of cutaneous metastatic breast carcinoma: a retrospective, single-institution review

Choo,

2023

Arch Dermatol Res

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Breast carcinoma is among the most common visceral malignancies to metastasize to the skin, but few studies have comprehensively characterized the patient and breast cancer-speci c features of cutaneous metastases of primary breast carcinoma (CMBC). In this case control study, we identi ed key clinical, histopathologic, and molecular features of CMBC within a large, single-institution cohort. We further strati ed between locoregional and distant cutaneous metastases to identify possible predictors of the eventual skin phenotype. Ninety-four (94) histologically con rmed cases of CMBC biopsied between January 2005 and December 2021 were identi ed via review of the University of Chicago Medicine pathology report database. Of these, 37 were locoregional and 57 were distant cutaneous metastases.The mean duration between diagnosis of breast cancer and CMBC was 7.02 years (range, 0-37 years). Histologically, most primary breast tumors were invasive ductal carcinomas (IDC; 82.2%). On subgroup analysis, older age and underlying invasive lobular carcinoma (ILC) were signi cantly associated with distant patterns of CMBC (P = 0.026 and 0.008, respectively). Notably, patients with distant CMBC also demonstrated worse functional status, more recalcitrant disease, and higher mortality than those with locoregional CMBC. Our analysis represents one of the largest cohorts to date of CMBC and highlights the importance of longitudinal skin surveillance in the detection of CMBC. Furthermore, our ndings suggest that the primary breast cancer subtype may in uence the eventual presentation of metastatic disease to the skin, a novel nding that warrants further exploration.

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Metástasis cutáneas de cáncer de mama: 8 años de revisión en un centro de tercera complejidad

Cited by 9 publications

References 13 publications

Metástasis cutáneas en pacientes con cáncer de mama. Serie de casos

Metástasis cutáneas en pacientes con cáncer de mama. Serie de casos

Cutaneous Metastatic Cancer: Carcinoma Hemorrhagiectoides Presenting as the Shield Sign

Predictors and outcomes of cutaneous metastatic breast carcinoma: a retrospective, single-institution review

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