Metástasis en tejido celular subcutáneo de glioblastoma multiforme: caso clínico y revisión de la literatura

Porto, Natalia Frade; Fernández, Juan Delgado; Pallero, María de los Ángeles García; Cuesta, Juan Ramón Penanes; Pulido-Rivas, P; Simoes, Ricardo Gil

doi:10.1016/j.neucir.2018.03.005

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…This discovery adds a new possibility on how to interpret the reported cases of distant metastasis, which yet has to be investigated. We found seven cases in literature up‐to‐date where glioblastoma invaded the parotid gland 14‐20 …”

Section: Discussionmentioning

confidence: 99%

Extra‐CNS metastasis of glioblastoma multiforme to cervical lymph nodes and parotid gland: A case report

Alhoulaiby

Abdulrahman

Alouni

et al. 2020

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Extra‐CNS metastasis of glioblastoma multiforme to cervical lymph nodes and parotid gland: A case report

Alhoulaiby

Abdulrahman

Alouni

et al. 2020

Clinical Case Reports

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Mesenchymal-Type Genetic Mutations Are Likely Prerequisite for Glioblastoma Multiforme to Metastasize Outside the Central Nervous System: An Original Case Series and Systematic Review of the Literature

Laurin,

Treffy,

Connelly

et al. 2025

World Neurosurgery

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Glioblastoma multiforme: a multi-omics analysis of driver genes and tumour heterogeneity

et al. 2021

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Glioblastoma (GBM) is the most aggressive and common brain cancer in adults with the lowest life expectancy. The current neuro-oncology practice has incorporated genes involved in key molecular events that drive GBM tumorigenesis as biomarkers to guide diagnosis and design treatment. This study summarizes findings describing the significant heterogeneity of GBM at the transcriptional and genomic levels, emphasizing 18 driver genes with clinical relevance. A pattern was identified fitting the stem cell model for GBM ontogenesis, with an upregulation profile for MGMT and downregulation for ATRX, H3F3A, TP53 and EGFR in the mesenchymal subtype. We also detected overexpression of EGFR, NES, VIM and TP53 in the classical subtype and of MKi67 and OLIG2 genes in the proneural subtype. Furthermore, we found a combination of the four biomarkers EGFR, NES, OLIG2 and VIM with a remarkable differential expression pattern which confers them a strong potential to determine the GBM molecular subtype. A unique distribution of somatic mutations was found for the young and adult population, particularly for genes related to DNA repair and chromatin remodelling, highlighting ATRX, MGMT and IDH1. Our results also revealed that highly lesioned genes undergo differential regulation with particular biological pathways for young patients. This multi-omic analysis will help delineate future strategies related to the use of these molecular markers for clinical decision-making in the medical routine.

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Metástasis en tejido celular subcutáneo de glioblastoma multiforme: caso clínico y revisión de la literatura

Cited by 5 publications

References 13 publications

Extra‐CNS metastasis of glioblastoma multiforme to cervical lymph nodes and parotid gland: A case report

Extra‐CNS metastasis of glioblastoma multiforme to cervical lymph nodes and parotid gland: A case report

Mesenchymal-Type Genetic Mutations Are Likely Prerequisite for Glioblastoma Multiforme to Metastasize Outside the Central Nervous System: An Original Case Series and Systematic Review of the Literature

Glioblastoma multiforme: a multi-omics analysis of driver genes and tumour heterogeneity

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