Metastasis from tongue squamous cell carcinoma to the kidney

Abstract

Metastasis to the kidney from other primary sites is extremely rare. Previous studies reported the lung as the most common primary site. Distant metastasis from the tongue to the kidney is exceedingly rare. Herein, we describe a case of metastatic squamous cell carcinoma to the kidney in a 71-year-old male with a detailed discussion of differentiating it from potential mimickers. The patient underwent a total glossectomy and bilateral cervical lymph node dissection. A diagnosis of well-differentiated squamous cell carcinoma of the tongue was rendered and the tumor was staged pT3 pN3b. Within two years of initial presentation, the patient developed widely metastatic disease, including pulmonary nodules, renal masses, left adrenal mass, and pancreatic mass. Accurate diagnosis of a secondary involvement of the kidney by a metastatic tumor requires the appropriate correlation of clinical and imaging findings as well as morphologic and immunohistochemical clues.

Base of Tongue Squamous Cell Carcinoma With Metastasis to the Mandibular Symphysis: A Case Report

“…Distant metastases in oropharyngeal SCC are rare. The most common sites of distant metastasis include the lungs, bone, and liver [1,2,[4][5][6][7]. Less common sites of metastasis for OP SCC include skin, bone marrow, brain, kidneys, eyes, and heart [1,3,[8][9][10].…”

“…Squamous cell carcinoma (SCC) is the most common malignancy of the oropharynx (OP). SCC represents about 90% of OP malignancies and of those, about 25-40% involve the tongue [1][2][3]. Treatment of OP SCC includes chemotherapy, radiation, surgery, or a combination of these.…”

“…Treatment of OP SCC includes chemotherapy, radiation, surgery, or a combination of these. Five-year survival of OP SCC is about 50% [1]. Oropharyngeal SCC can metastasize via direct extension, lymphatics, or hematogenously.…”

“…The most common sites of distant metastasis include the lungs, bone, and liver [1,2,[4][5][6][7]. Other less common sites of metastasis for OP SCC include skin, bone marrow, brain, kidneys, eyes, and heart [1,3,[8][9][10]. Patients with these distant metastases usually have a poor prognosis and are treated palliatively [9][10][11].…”

Secondary Tumors of the Kidney: A Comprehensive Clinicopathologic Analysis

“…76 Head and Neck/ENT Head and neck/ENT tumors can represent another source of renal metastasis with an incidence of 6% to 9.3%. [4][5][6]27 Squamous cell carcinomas of the head and neck, [77][78][79] sinonasal adenoid cystic tumors, 80 and salivary/ lacrimal gland tumors 81,82 with metastasis to the kidney have all been reported in the literature. Metastasizing pleomorphic adenomas involving the kidney have also been reported.…”