Metastasis-Induced Acute Pancreatitis in Small Cell Bronchogenic Carcinoma

Management of metastases-induced acute pancreatitis in small cell carcinoma of the lung

“…MIAP developed in only two of them. This corresponds to the occurrence rate of 3.3% compared with 7.5% reported by Yeung et al, 4 and is less than the 20% to 40% rate of SCCL metastases to the pancreas reported in autopsy This suggests that not all cases of pancreatic metastases present as clinical pancreatitis. Mechanisms postulated for development of acute pancreatitis include mechanical ductal obstruction and rupture or vascular compromise secondary to tumor invasion and compression from enlarged peripan-creatic lymph nodes.…”

A case of metastasis‐induced acute pancreatitis in a patient with small cell lung cancer

“…These cases arose from SCLC (50.0%), adenocarcinoma (34.6%), squamous cell carcinoma (11.5%), and large cell carcinoma (3.9%) [2]. At postmortem examination, metastasis to the pancreas is found in 24-40% of patients with SCLC [1]. On the other hand, MIAP occurred in only 0.12% of the patients with lung carcinoma who were investigated in a study by Stewart et al [3].…”

“…There is no established treatment strategy for MIAP with SCLC. However, a few retrospective studies have reported that aggressive chemotherapy plus conventional treatment for acute pancreatitis prolonged overall survival, especially in patients with good ECOG-PS [1,[3][4][5]. However, these studies were subject to some limitations.…”

“…Pancreatic metastases are a common autopsy finding in advanced lung cancer, especially in small cell lung cancer (SCLC), but metastasis-induced acute pancreatitis (MIAP) is unusual [1]. Therefore, little evidence is available regarding treatment strategies for MIAP with SCLC.…”

Pancreatitis aguda e ictericia obstructiva secundaria a metástasis de cáncer de pulmón

“…El tratamiento de la ictericia es paliativo, con un pronóstico que varía según est e producida por met astasis hep aticas o si la causa es obstructiva 3,5 . Si se puede realizar CPRE con colocación de stent o cirugía desobstructiva 3,11 el pronóstico mejora.…”