Metastasis of invasive ductal breast cancer in the subcutaneous tissue of the back: Report of a relapse at 15 years

Huatuco, René M. Palacios; Ramírez, Mariano F.; Stoppani, Ignacio; Santos, Horacio Mendoza; Mayer, Horacio F.

doi:10.1016/j.ijscr.2023.107967

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…Despite soft tissue representing more than 50% of total body mass and receiving a large portion of total cardiac output, metastasis to soft tissue is very uncommon. 2,11 Various theories have been proposed to account for the relative paucity, including constant cellular trauma resulting from muscle contraction, heightened permeability of tumor cells, specific homeostatic factors, and pH fluctuations that impede tumor cell growth. 15,17 In this study, a retrospective analysis was conducted on patients who underwent surgical excision of soft tissue masses over 7 years at a large cancer center, identifying a total of 77 patients with visceral malignant soft tissue metastases.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Information in the literature regarding the clinical presentation, treatment, and oncological outcomes of cancer soft tissue metastases is limited, primarily reported in the form of case reports 9 , 10 , 11 , 12 and case series. 1 , 2 , 4 , 13 , 14 , 15 This is why there is still controversy surrounding the optimal therapeutic approach and expected oncological outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Surgical resection of soft tissue metastasis in cancers: A single‐center study of 77 cases over a 7‐year period

Ye,

Hu,

Sun

et al. 2023

Cancer Medicine

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IntroductionSoft tissue metastasis (STM) of cancers, encompassing skeletal muscle and subcutaneous tissue metastasis, is less common due to unique homeostatic conditions. With longer life expectancy and the advent of new imaging modalities, clinical physicians will increasingly encounter and manage such cases. This study retrospectively reviewed cases of STM in visceral cancers who underwent surgery at Fudan University Shanghai Cancer Center over a 7‐year period.MethodsData were collected through a comprehensive review of medical records, including demographic variables, primary tumor characteristics, surgical data, tumor pathology, and outcomes. Survival analysis was performed using Kaplan–Meier curves.ResultsThe study included 77 cases with a median follow‐up period of 854 days. The most common primary tumor sites were the lung (11) and breast (10). The abdominal wall was the most frequent site of metastasis. The combination of visceral metastasis, age over 52 years, and a history of primary tumor correlates with a poorer prognosis. Surgical‐related metastases are associated with a higher degree of differentiation. Additionally, we have identified a better prognosis for patients with cancer of unknown primary (CUP) exhibiting potential resectable soft tissue metastases.ConclusionThe combination of visceral metastasis, age over 52 years, and a history of primary tumor suggest a poorer prognosis. While no significant impact on survival was observed for patients with lymph node metastasis. Surgical‐related metastases are associated with a higher degree of differentiation. CUP patients with potentially resectable soft tissue metastases should be considered for surgical intervention.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surgical resection of soft tissue metastasis in cancers: A single‐center study of 77 cases over a 7‐year period

Ye,

Hu,

Sun

et al. 2023

Cancer Medicine

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Oligo-Metastatic Ductal Breast Carcinoma Presenting as a Subcutaneous Nape Nodule: A Case Report

Behbehani Pour,

Abdullah,

Alsayed

et al. 2024

Cureus

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Breast cancer (BC) in females is the most diagnosed cancer and the leading cause of cancer death in women worldwide, followed by lung, colorectal, and cervical cancers. For oligo-metastatic (OM) cancers, the best definition is a maximum of five metastatic foci, not necessarily located in the same organ or anatomic region, all potentially treatable by ablative local treatment: either surgical resection or radiation when accessible. Oligo-metastatic breast cancer (OM-BC) is currently arising as an emerging entity with more focused research needed to upgrade the guidelines for best management. Given the heterogeneous nature of BC metastasis, evolving molecular mechanisms have been shown to play a lead way for possible future-guided preventive therapy. Soft tissue metastases are particularly very rare and usually seen arising in subcutaneous fat, fascia, or muscle fibers. They can be confused with a primary soft tissue sarcoma and hence it is important to obtain an accurate differential diagnosis. We hereby present a case of OM-BC presenting as a metastatic soft tissue nodule in the nape in a 73-year-old Kuwaiti lady diagnosed with left breast cancer in 2016 (ductal type) with otherwise free metastatic workup in our practice at Kuwait Cancer Control Center (KCCC).

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Metastasis of invasive ductal breast cancer in the subcutaneous tissue of the back: Report of a relapse at 15 years

Cited by 2 publications

References 9 publications

Surgical resection of soft tissue metastasis in cancers: A single‐center study of 77 cases over a 7‐year period

Surgical resection of soft tissue metastasis in cancers: A single‐center study of 77 cases over a 7‐year period

Oligo-Metastatic Ductal Breast Carcinoma Presenting as a Subcutaneous Nape Nodule: A Case Report

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