Metastasis of Laryngeal Squamous Cell Carcinoma to Bilateral Thigh Muscles

Lucas, Zarah; Mukherjee, Akash; Chia, Stanley H.; Veytsman, Irina

doi:10.1155/2014/424568

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…Jelena Petrović 1,3 , Dragana Šobić Šaranović 1,3 , Jovica Milovanović 2,3 , Ana Jotić 2,3 , Strahinja Odalović 1,3 , Isidora Grozdić Milojević 1,3 , Milica Stojiljković 1,3 , Vera Artiko 1,3 Sažetak Uvod: Cilj ovog istraživanja je procena dijagnostičke vrednosti pozitronske emisione tomografije/kompjuterizovane tomografije koristeći fluor-18 fluorodeoksiglukozu (18F-FDG PET/CT) u post-terapijskom praćenju laringealnog skvamocelularnog karcinoma (SCC) i preživljavanju.…”

Section: Author Contributionsunclassified

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The role of 18F-FDG PET/CT in the follow-up of laryngeal cancer after treatment

Petrović¹,

Šobić-Šaranović²,

Milovanović³

et al. 2023

Medicinska istraživanja

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Introduction: The aim of this investigation was to estimate the diagnostic performance of positron emission tomography/computed tomography using fluorine-18 fluoro-deoxyglucose (18F-FDG PET/CT) in the follow-up of post-treatment laryngeal squamous cell carcinoma (SCC) and the survival rate. Material and methods: Fifty seven patients (50 males, 7 females), mean age (68.3±6.7), with post-treatment laryngeal SCC were investigated. Indications for 18F-FDG PET/CT were: post-surgery staging, post-therapy restaging with positive/uncertain CT, follow-up, suspected recurrence on CT. 18F-FDG PET/CT findings were compared to the clinical follow-up of up to 10 years after imaging. The degree of metabolic activity was analyzed visually and semi-quantitatively using the maximum standardized uptake value (SUVmax). Results: A high accumulation of radiopharmaceutical was found in 41 (71.9%) patients who were considered true positive, physiological in 14 patients (24.5%) and only two males (3.5%) were false positive. Overall sensitivity of 18F-FDG PET/CT was 95.3%, specificity 100.0%, positive predictive value 100.0%, negative predictive value 87.5% and accuracy 96.5%. In 19 cases (33.3%) PET/CT findings significantly influenced further management of the patients. Progression-free survival (PFS) in the 18F-FDG positive group was 41.1±12.7 months. Statistically significant correlation between SUVmax and PFS was not observed (p>0.05). Conclusion: 18F-FDG PET/CT is a valuable tool for the follow-up of laryngeal SCC due to its high sensitivity, specificity, PPV, NPV and accuracy. It can influence the patients' management in a significant number of cases. Patients with negative 18F-FDG PET/CT findings had longer PFS than those with positive ones, but without statistical significance. SUVmax was not proven to be a strong predictor of patients' disease-free survival.

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Section: Author Contributionsunclassified

“…Laryngeal cancer may spread by direct extension to adjacent structures, by metastases to regional cervical lymph nodes, or more distantly, through the blood stream. Distant metastases to the lungs are most common (3). A five-year survival rate is around 60.3% and it depends on the stage (4).…”

Section: Introductionmentioning

confidence: 99%

The role of 18F-FDG PET/CT in the follow-up of laryngeal cancer after treatment

Petrović¹,

Šobić-Šaranović²,

Milovanović³

et al. 2023

Medicinska istraživanja

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“…Basal cell carcinoma, the most common type of skin cancer, is unlikely to spread to distant areas [60]. Distant metastasis from laryngeal cancer is also not often observed [61]. Moreover, at the beginning of their formation, cancers of most organs, still at the stage of carcinoma in situ, do not present lymph node invasion and can therefore be described locally, without recourse to the notion of metastases.…”

Section: A Model At Cell Scalementioning

confidence: 99%

From Cell–Cell Interaction to Stochastic and Deterministic Descriptions of a Cancer–Immune System Competition Model

2023

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We consider a cell–cell interaction model of competition between cancer cells and immune system cells, first introduced in the framework of the thermostatted kinetic theory, and derive a master equation for the probability of the number of cancer cells and immune system cells for a given activity. Macroscopic deterministic equations for the concentrations and mean activities of cancer cells and immune system cells are deduced from the kinetic equations. The conditions for which the 3Es of immunotherapy (elimination, equilibrium, and escape) are reproduced are discussed. Apparent elimination of cancer followed by a long pseudo-equilibrium phase and the eventual escape of cancer from the control of the immune system are observed in the three descriptions. The macroscopic equations provide an analytical approach to the transition observed in the simulations of both the kinetic equations and the master equation. For efficient control of activity fluctuations, the steady states associated with the elimination of either cancer or immune system disappear and are replaced by a steady state in which cancer is controlled by the immune system.

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“…Metastasis comprised about 90 % of deaths stemming from all human neoplasms and it was mostly associated with malignant progression of tumors. In 2015, around 13.560 new cases are estimated to be diagnosed with LSCC in the US (47) with an average rate of 19% metastasis (48).…”

Section: Cslcs and Larynx Cancer Metastasismentioning

confidence: 99%

New Insights into Laryngeal Squamous Cell Carcinoma: Cancer Stem-Like Cells

Güzel¹,

Karataş²,

Özgürses³

et al. 2015

Cancer Res Front

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The Cancer Stem-Like Cells (CSLCs) are cells with tumorigenic potential, which are involved in initiation, progression and spread of the tumor. Recent evidences in the last decade have suggested the existence of CSLCs in distinct types of tumors such as lung, brain, breast, prostate, colon, head and neck, ovarian and larynx cancers. They are identified by their tissue specific stem cell-like properties including self-renewal and having potential to differentiate.Laryngeal squamous cell carcinoma (LSCC), originating from laryngeal epithelial tissue, is one of the most commonly diagnosed malignancies among the head and neck tumors worldwide. LSCC is frequently diagnosed among middle-aged people and its incidence has been reported to increase each year. Therapeutic options mostly cannot give positive clinical response especially for the advanced LSCC cases. LSCC is still one of the important causes of cancer deaths, particularly in men, worldwide, although the technologies in detection and diagnosis of LSCC have been significantly improved recently.In this review, we have summarized the most current literature to understand the functions and roles of CSLCs in human LSCC. We believe that this review will contribute to knowledge of scientist not only working in LSCC field, but also studying the CSLCs in other cancers and diseases, and will help elucidating the roles of CSLCs implicated in LSCC initiation, development, progression, and chemo-radioresistance.

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Metastasis of Laryngeal Squamous Cell Carcinoma to Bilateral Thigh Muscles

Cited by 8 publications

References 9 publications

The role of 18F-FDG PET/CT in the follow-up of laryngeal cancer after treatment

The role of 18F-FDG PET/CT in the follow-up of laryngeal cancer after treatment

From Cell–Cell Interaction to Stochastic and Deterministic Descriptions of a Cancer–Immune System Competition Model

New Insights into Laryngeal Squamous Cell Carcinoma: Cancer Stem-Like Cells

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