Metastasis of solid tumours in bone marrow: a study from Kashmir, India

The metastasis of bone marrow by the solid tumors is a sign of advanced stage of disease and poor prognosis. The aim of this study was to assess the pattern of bone marrow involvement of different solid tumors and their correlation with hematological findings. In a retrospective study we evaluated 434 aspirates and 76 biopsy sections from 124 cases of different types of solid tumors previously diagnosed on the basis of their clinical and histopathological findings. The hematological profile of the patients was done and correlated with the bone marrow findings. The study was carried out at a medical college hospital of northern India. Out of 124 cases of solid tumors 31 (25%) have metastasized to bone marrow. The highest number 25 (36%) of bone marrow involvement was seen in carcinoma prostate followed by gastric carcinoma and melanoma (25%) The least number (14.2%) cases of bone marrow metastasis were observed in endometrial carcinoma. Anemia was found the commonest (71.4%) hematological finding followed by thrombocytopenia in 45.1% cases. The bone marrow examination is an easy, convenient, sensitive and cost effective procedure for assessment of staging and monitoring of prognosis of solid tumors.

Section: Discussionmentioning

confidence: 99%

“…The malignancies of prostate, breast, lungs, kidney, thyroid and gastric in adults and neuroblastoma and rhabdomyosarcoma in children are the primary tumors which frequently involve bone marrow [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Metastasis of Solid Tumors in Bone Marrow: A Study from Northern India

Mehdi

Bhatt

2011

“…Idris M et al [7] have reported 15.39% cases of haematological malignancies as lymphoma in Abbotabad. However RA Tasleem et al [24] have reported lymphoma only in 2/318 bone marrow examinations. Bhutani et al [5] have reported that occurrence rates of lymphomas are highest in the United States, Europe and Australia and the lowest rates are seen in Asia.…”

Section: Lymphomamentioning

confidence: 99%

“…Other studies on metastasis have reported 8/319 cases Tasleem RA [24] et al, 19/5420 cases -Ozkalemkas F et al [25], 25/ 11,820 cases -Ringenberg QS et al [26], 5/1569 cases Atac B et al [27] and 2/627 cases Al Ghazaly et al [7].…”

Section: Metastasismentioning

confidence: 99%

Hematological malignancies diagnosed by bone marrow examination in a tertiary hospital at Uttarakhand, India

Kusum

Negi

Gaur

et al. 2008

“…However, they can also be frequently reported on examination of only aspirates [2]. Previously many studies have been conducted to evaluate bone marrow infiltration by solid tumors [3][4][5]. However, there are few studies which have analysed cases of bone marrow involvement in neuroblastoma with regards to its correlation with hematological profile and usefulness of bone marrow examination procedures [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Bone Marrow Involvement in Neuroblastoma: A Study of Hemato-morphological Features

Rastogi

Naseem

Varma

et al. 2014

Bone marrow involvement in neuroblastoma indicates advanced stage of disease. The recent use of autologous bone marrow ''rescue'', has provided an additional important reason for accurate assessment of bone marrow status in newly diagnosed patients. In this study, we analyzed 44 cases of neuroblastoma for bone marrow infiltration status and their hematological parameters. Eighty-eight bone marrow aspirate and trephine touch imprint smears and 44 trephine biopsy sections were examined in these 44 patients. Of these, 24 cases (54.5 %) showed marrow infiltration. Leucopenia and bicytopenia were significantly (p \ 0.05) associated with marrow infiltration. Both bone marrow aspirate and biopsy were positive for infiltration in 16 out of 24 positive cases. Only aspirate smears were positive in 4 and only trephine biopsy in another 4 cases. The pattern of infiltration consisted of rosette formation in 40.7 % cases on aspirate smears and 22.2 % cases in trephine biopsies. Remaining cases showed diffuse and interstitial presence of tumor cells and cases positive only on trephine biopsy, showed marked stromal reaction. Bilateral trephine biopsies combined with aspirate smears picked up all positive cases compared to when they were assessed alone.