Metastasis prevention: targeting causes and roots

Schegoleva, Anastasia A; Khozyainova, Anna A.; Gerashchenko, Tatiana S.; Жуйкова, Л. Д.; Denisov, Evgeny V.

doi:10.1007/s10585-022-10162-x

Cited by 12 publications

(14 citation statements)

References 174 publications

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“…35 Metastasis prevention is a high-priority challenge for oncology. 36 This research describes how melatonin appears to have potential as a therapeutic strategy for inhibiting chondrosarcoma cell proliferation and metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Chondrosarcomas are chemoresistant, radioresistant, and highly likely to metastasize, depending on the tumor grade 35 . Metastasis prevention is a high‐priority challenge for oncology 36 . This research describes how melatonin appears to have potential as a therapeutic strategy for inhibiting chondrosarcoma cell proliferation and metastasis.…”

Section: Discussionmentioning

confidence: 99%

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Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression

Tran

Lin²,

Chang

et al. 2023

Journal of Pineal Research

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Chondrosarcoma has a high propensity to metastasize and responds poorly to chemotherapy and radiation treatment. The enzymatic activity of matrix metalloproteinases (MMPs) is very important in chondrosarcoma metastasis. Melatonin exhibits anticarcinogenic activity in many types of cancers by suppressing the expression of certain MMP family members, but this has not yet been clearly determined in chondrosarcoma. Our study demonstrates that MMP7 plays an essential role in chondrosarcoma cell proliferation, migration, and anoikis resistance. We also found that MMP7 is highly expressed in chondrosarcomas. Our in vitro and in vivo investigations show that melatonin strongly inhibits chondrosarcoma cell proliferation, migration, and anoikis resistance by directly suppressing MMP7 expression. Melatonin reduced MMP7 synthesis by promoting levels of miR‐520f‐3p expression, which were downregulated in human chondrosarcoma tissue samples. Pharmacological inhibition of miR‐520f‐3p markedly reversed the effects of melatonin upon chondrosarcoma proliferation and metastasis. Thus, our study suggests that melatonin has therapeutic potential for reducing the tumorigenesis and metastatic potential of chondrosarcoma via the miR‐520f‐3p/MMP7 axis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression

Tran

Lin²,

Chang

et al. 2023

Journal of Pineal Research

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“…Many studies have reported that the EMT process is related to the lymph node metastasis process of malignant tumors [16]. Many EMT-related studies usually focus on the study of a single gene, so the conclusions drawn are often inconsistent [17,18]. This project is based on 200 common EMT-related genes to screen out miRNAs related to EMT genes.…”

Section: Discussionmentioning

confidence: 99%

Construction of epithelial-mesenchymal transition related miRNAs signatures as prognostic biomarkers in gastric cancer patients

Xiao

Zhang

Liu

et al. 2022

Preprint

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Aim: To identify the potential post-healing EMT related miRNAs associated with lymph node metastatic gastric cancer (LNMGC). Methods: Both RNA expression and clinical medical data were obtained from the TCGA dataset. We performed differential expression and normalization analysis of miRNAs. Cox linear regression model confirmed the differentially expressed miRNAs (DEmiRNAs) and clinical medical parameters related to overall survival (OS). The role of target genes of DEmiRNAs was determined according to the role enrichment analysis. Results: We obtained a total of 7531 DEmRNAs and 267 DEmRNAs, of which 185 DEmRNAs were down-regulated and 82 DEmRNAs were up-regulated. We randomly divided the LMNGC cases (n=291) into a training group (n=207) and a test group (n=84). The results showed that a total of 103, 11, 13 and 83 overlapping genes were associated with hsa-mir-141-3p, hsa-mir-4664-3p, hsa-mir-125b-5p and hsa-mir-7-5p, respectively. Kaplan-Meier determined that these four miRNAs can effectively distinguish high-risk and low-risk groups, and have a good indicator role (all p<0.05). Multivariate cox regression analysis also showed that EMT-related miRNA predictive model and lymph node metastasis were both prognostic risk factors (all p<0.05). The ROC curve showed that this feature had high accuracy (AUC>0.7, p<0.05). In addition, KEGG analysis showed that EMT-related pathways were mainly enriched in HIF-1 signaling pathway and focal adhesion. Conclusions: Our study demonstrated that EMT-related miRNAs could serve as independent prognostic markers in pN 1-3 GC patients.

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“…Current medicines for metastasis treatment still focus on tumor shrinkage and proliferation control; however, they cannot prevent the occurrence of metastasis completely. 4 In particular, osteosarcoma presents a notable case with a less than 30% five-year survival rate, primarily attributed to distant lung metastasis. 5,6 Despite patients receiving surgery combined with adjuvant radiotherapy and chemotherapy in the early stage, the outcomes were not satisfactory.…”

Section: Introductionmentioning

confidence: 99%

Europium-doped hybrid nano-complexes: a potential strategy for metastasis prevention in osteosarcoma

Wang,

Tung,

Sung

et al. 2024

Mater. Adv.

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Metastasis prevention: targeting causes and roots

Cited by 12 publications

References 174 publications

Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression

Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR‐520f‐3p production and suppressing MMP7 expression

Construction of epithelial-mesenchymal transition related miRNAs signatures as prognostic biomarkers in gastric cancer patients

Europium-doped hybrid nano-complexes: a potential strategy for metastasis prevention in osteosarcoma

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