Metástasis tiroidea de carcinoma lobulillar de mama

Egana, Nerea; Socias, Catalina; Matteucci, T.; Bilbao, Ismene; Alvárez-Coca, Mariano

doi:10.1016/j.endonu.2011.09.009

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…In the reports containing histological information, breast cancer is generically referred to as “adenocarcinoma” [ 3 , 14 , 15 ]. Where indicated, the most prevalent breast cancer is ductal infiltrating carcinoma [ 6 , 8 , 10 ], reported in seven cases, while invasive lobular carcinoma was reported in only our case and in a case described by Egana et al [ 12 ]. Not all the studies reviewed reported the site of recurrence.…”

Section: Discussionmentioning

confidence: 54%

“…In autopsy series, breast cancer, lung cancer and melanoma were found to be the most frequent malignancies to metastasize to the thyroid [ 11 ]. Clinical and surgical series of patients showed that breast carcinoma is the second most common primary tumour to result in symptomatic thyroid metastases, the first being clear cell renal cancer [ 5 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…The development of metastases of the thyroid gland does not appear to be age-dependent, and seems to be more frequent in women [ 1 ]. The median age at diagnosis of metastases to the thyroid gland is 51 years (range: 22–83 years) [ 9 , 12 ]. Time-to-detection and time from presentation to death differ among reports.…”

Section: Discussionmentioning

confidence: 99%

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It is no longer the time to disregard thyroid metastases from breast cancer: a case report and review of the literature

et al. 2018

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BackgroundMetastases to the thyroid gland are more frequent than previously thought, although most of them are occult or not clinically relevant. Overall, only 42 cases of metastases to thyroid from breast cancer have been reported thus far. Here we report the case of a patient with breast cancer metastatic to the thyroid. We also review the 42 previously reported cases (published between 1962 and 2012). This is the first review about metastases to thyroid gland from breast cancer.Case presentationA 64-year-old woman of Caucasian origin was diagnosed with a lobular invasive carcinoma of the breast (luminal A, stage II). She received adjuvant chemotherapy, followed by endocrine therapy. During follow-up, fine-needle cytology of a thyroid nodule revealed malignant cells that were estrogen-positive, which suggested a diagnosis of metastases to the thyroid. Imaging did not reveal any other metastatic site and showed only enlargement of the left thyroid lobe and an inhomogeneous pattern of colloid and cystic degeneration and calcifications. The patient underwent left hemithyroidectomy. Histology of thyroid tissue showed a colloid goitre containing dispersed small atypical neoplastic cells with eccentric nuclei. Immunohistochemistry showed cytokeratin-19 and oestrogen receptor, but not tireoglobulin, e-cadherin or cytokeratin-7, thereby confirming metastases from a lobular breast carcinoma. Hormonal treatment is ongoing.ConclusionThis case report and first review of the literature on metastases to thyroid from breast cancer highlight the importance of a correct early diagnostic work-up in such cases. Indeed, a primary lesion should be distinguished from metastases given the different treatment protocol related to primary cancer and the clinical impact on prognosis.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

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It is no longer the time to disregard thyroid metastases from breast cancer: a case report and review of the literature

et al. 2018

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“…Thyroid metastases from breast cancer, particularly invasive lobular carcinoma, are rare. To the best of our knowledge, only one case of invasive lobular carcinoma with metastasis has been reported in the literature [3].…”

Section: Introductionmentioning

confidence: 99%

Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review

et al. 2018

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Metastasis from primary cancer to the thyroid is uncommon in breast cancer. Here we present a case of lobular breast carcinoma that metastasized to the thyroid. A 54-year-old woman without symptoms was admitted to our institution for staging of the lymph node above the left clavicle. An 18F-fluoro-deoxy-D-glucose positron emission tomography scan was performed for staging, and low uptakes were observed in the left supraclavicular and cervical lymph nodes. High uptake was seen in the posterior and lower left lobe of the thyroid. Histologic findings indicated lobular breast carcinoma (positive GATA3, loss of E-cadherin expression) metastatic to the thyroid with a luminal profile. Immunohistochemical analysis was negative for primary thyroid or parathyroid carcinoma. To our knowledge, this is the first report of a patient presenting a metastatic invasive lobular carcinoma in the thyroid and lymph nodes without a prior diagnosis of breast cancer.

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“…[2] Thyroid metastases are uncommon in standard clinical practice, and most metastases are discovered only at autopsy. [3] In their study Papi et al . they found that thyroid metastasis from a given primary tumor histotype varies widely, depending on ethnic/demographic and epidemiological differences in major cancer types in the different populations.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Diffuse Fluorodeoxyglucose Uptake in Thyroid Gland Diagnosed by Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography

Win

Aparici

2014

World J Nucl Med

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Our patient is a female who was first diagnosed with breast cancer at the age of 23. A follow-up fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) at age 44 revealed diffuse high FDG uptake in an enlarged thyroid gland. Fine-needle aspiration (FNA) of the thyroid mass revealed estrogen receptor/progesterone receptor negative, human epidermal growth factor receptor 2+ breast cancer. To the best of our knowledge, this is the first case to report breast cancer metastasis to the thyroid in a diffuse pattern on FDG-PET/CT. Bilateral diffuse uptake of FDG in thyroid is the most commonly associated with benign conditions. However, FNA biopsies need to be done to rule out metastatic disease in thyroid lesions with diffuse high FDG uptake, especially for patients with history of cancer.

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Metástasis tiroidea de carcinoma lobulillar de mama

Cited by 9 publications

References 6 publications

It is no longer the time to disregard thyroid metastases from breast cancer: a case report and review of the literature

It is no longer the time to disregard thyroid metastases from breast cancer: a case report and review of the literature

Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review

Bilateral Diffuse Fluorodeoxyglucose Uptake in Thyroid Gland Diagnosed by Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography

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