Metastasis to the breast from an adenocarcinoma of the colon

Ho, Yvonne Y.; Lee, Wai-Kit

doi:10.1002/jcu.20490

Cited by 23 publications

(27 citation statements)

References 13 publications

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“…The majority of metastases (55%) were to the left breast (often upper outer quadrant), with 6 (30%) to the right breast, and 2 bilateral (10%) [10]. Two of three reported male patients exhibited metastases in the left breast only [14, 15, 17]. CRC metastases to the breast averaged 3.5 cm in size and ranged from 1 to 11 cm.…”

Section: Discussionmentioning

confidence: 99%

Primary Colorectal Adenocarcinoma Metastatic to the Breast: Case Report and Review of Nineteen Cases

Shackelford

Allam-Nandyala

Kiluk

et al. 2011

Case Reports in Medicine

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Metastases to the breast from extramammary primaries are uncommon and account for 0.5–6% of all breast malignancies (Georgiannos et al., 2001, and Vizcaíno et al., 2001). Malignant melanoma, lymphoma, and lung and gastric carcinomas are the most frequently encountered nonmammary metastases to the breast in adults (Georgiannos et al., 2001, and Chaignaud et al., 1994). Primary colorectal adenocarcinoma (CRC) metastatic to the breast is extremely rare, with the medical literature having only 19 recorded cases. Typically CRC metastatic to the breast is indicative of widely disseminated disease and a poor prognosis. Here we present a case of poorly differentiated colon cancer metastatic to the breast and review the current literature on this rare event.

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Section: Discussionmentioning

confidence: 99%

Primary Colorectal Adenocarcinoma Metastatic to the Breast: Case Report and Review of Nineteen Cases

Shackelford

Allam-Nandyala

Kiluk

et al. 2011

Case Reports in Medicine

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“…Finally, pathological examination is the most useful diagnosis technique. In H&E examination, metastatic tumor cells in the breast are shown to usually locate in the periductal or perilobular region, lacking in situ components and desmoplastic reaction (11,17). IHC staining may also help in differentiating the origin of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report

et al. 2017

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Breast cancer has the highest rate of incidence among all types of cancer in women. Only ~0.43% of breast malignancies occur as a result of metastatic lesions from extramammary tumors. The present study reports an extremely rare case of transverse colon cancer metastasizing to the bilateral ovaries and the left breast. The patient was a 47-year old female, who had a lump in the left breast without axillary lymphadenopathy. Specimens obtained by core needle biopsy were submitted for hematoxylin and eosin examination, and results revealed that the lump was a poorly differentiated adenocarcinoma. Since the patient had elevated levels of the carcinoembryonic antigen and a medical history of a Krukenberg tumor metastasized from colon cancer, immunohistochemical examinations were applied. Results identified that caudal-related homeobox protein 2 and cytokeratin 20 were positively stained, whilst cytokeratin 7 was negatively stained. Therefore, this patient was diagnosed as having colon cancer that had metastasized to the bilateral ovaries and the left breast. As the life expectancy of patients with cancer is increasing, types of metastases that used to be seen as rare are increasingly becoming more common. For clinicians, diagnosis should be cautious, and differential diagnosis should always be kept in mind.

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“…In patients with distant metastases, the five-year survival rate is approximately 10% [4]. Cancers of the colon, uterine corpus, breast and ovary frequently occur together, suggesting an underlying hormonal or dietary effect [5]. …”

Section: Discussionmentioning

confidence: 99%

A Malignant Mass in the Breast Is Not Always Breast Cancer

Selçukbiricik¹,

Tural²,

Bay³

et al. 2011

Case Rep Oncol

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A 37-year-old woman presented to the Internal Medicine Clinic with complaints of abdominal pain and constipation which had begun 3 months earlier. A colonoscopy was performed, and wall thickening of the sigmoid colon was detected. A biopsy of the sigmoid colon revealed a poorly differentiated, mucin-producing adenocarcinoma with a signet-ring pattern. No distant metastasis was detected. The patient was treated with chemotherapy consisting of 5-fluorouracil, leucovorin, and oxaliplatin. One and a half years later, a painless mass, which was not fixed to the skin, measuring 1 cm in diameter, was found in the lower outer quadrant of the left breast. A core biopsy of the mass was performed, and a histopathological report confirmed metastasis to the breast from mucinous adenocarcinoma of an intestinal primary.

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Metastasis to the breast from an adenocarcinoma of the colon

Cited by 23 publications

References 13 publications

Primary Colorectal Adenocarcinoma Metastatic to the Breast: Case Report and Review of Nineteen Cases

Primary Colorectal Adenocarcinoma Metastatic to the Breast: Case Report and Review of Nineteen Cases

Metastases of transverse colon cancer to bilateral ovaries (Krukenberg tumor) and the left breast: A case report

A Malignant Mass in the Breast Is Not Always Breast Cancer

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