Metastasis to the oral soft tissues: A review of 412 cases

Irani, Soussan

doi:10.4103/2231-0762.192935

Cited by 53 publications

(62 citation statements)

References 216 publications

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“…[2] Metastasis to the jaw bones mainly occurs in the posterior region of the mandible, ramus, and the condyle, which are rich in red bone marrow. Metastasis to the maxilla is rare and comprises one-fifth of all metastatic tumors to the jawbones.…”

Section: Introductionmentioning

confidence: 99%

Metastasis to the Jawbones: A review of 453 cases

Irani

2017

J Int Soc Prevent Communit Dent

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The purpose of the present article was to review the characteristics of the jawbone metastases to analyze all variables. A relevant English Literature search in PubMed, Scopus, and Google Scholar was performed. All variables such as age, gender, primary and secondary tumor sites were analyzed. There were 453 metastatic cases. The male-to-female ratio was 1.2:1, and the mean age of the patients was 53.4 years. The lung was the most common primary site in men, and breast in women. The most common metastatic site was the mandible, and adenocarcinoma was the most frequent histological diagnosis. Metastases to the jaw bones occur in the advanced stages of a malignancy hence; a careful examination of patients with jaw bone lesions is strongly suggested. Dentists, as well as general physicians, should take into consideration the possible presence of jaw metastases in cases which present atypical symptoms, especially in patients with known malignant disease.

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Section: Introductionmentioning

confidence: 99%

Metastasis to the Jawbones: A review of 453 cases

Irani

2017

J Int Soc Prevent Communit Dent

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“…In a previous literature review referring to 412 cases [5], Irani found that only 33% of oral metastases affected the soft tissues.…”

Section: Discussionmentioning

confidence: 99%

Multiple gingival metastasis of renal cell carcinoma: a case report

Boulanger

Gérard

Curien

2019

J Oral Med Oral Surg

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Introduction: Oral metastases are rare and represent only 1% of malignant diseases of the oral cavity, but they are often associated with poor prognosis. The primary tumor is recognizable in most cases; however, in 27.6% of cases, metastasis is the first clinical manifestation. Observation: An 82-year-old consulted for the recent appearance of a 1-cm-wide gingival tumor on 46. Since this patient had metastatic clear cell renal cell carcinoma, oral metastasis was confirmed by histopathology. In the following weeks, other oral metastases appeared. Palliative radiotherapy was the chosen treatment option, but the patient died before he could benefit from it. Discussion: Multiple oral metastases are rare, and metastasis of renal origin is not the most frequently encountered. The metastatic dissemination pathway described is hematogenous or lymphatic. Diagnosis is often easy if the primary tumor is already identified, but is a challenge if it is not, because the lesion often has a nonspecific appearance. Different surgical, radiotherapeutic, and medical therapeutic options exist, but are often palliative. A new immunotherapy route is under development and looks promising in the treatment of renal cell carcinoma. Conclusions: Oral metastasis often has poor prognosis, and management of the lesion is problematic. However, current research suggests a therapeutic and prognostic improvement.

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“…Chronic inflammation of gingiva may provide adequate conditions for metastatic tumour cell colonisation [1][2][3] .…”

Section: Introductionmentioning

confidence: 99%

“…Malignant tumours of the lung, breast, kidney, liver, bone, prostate, thyroid gland, skin, colon and female genital organs most commonly give metastases in oral region. The incidence of metastatic tumours of oral region is rising, according to the fact that patients with cancers live longer due to advances in cancer diagnosis and management 2,[4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

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Histopathological analysis of metastatic tumours of the oral cavity with example of metastatic renal cell carcinoma to tongue

Vučković¹,

Miladinović²,

Popović³

et al. 2020

Balkan J Dent Med

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SummaryBackground/Aim: Metastatic tumours make up only 1-3% of all malignant tumours of the oral region; however, in 25% of the total number of cases, they are the first sign of the disease. Usually, metastases in the oral region are followed by poor prognosis. Metastases are more common in the mandible than in the maxilla; in soft tissues, they most commonly occur in the attached gingiva and tongue. Malignant tumours of the lung, breast, kidney, liver, bone, prostate, thyroid gland, skin, colon and female genital organs most commonly give metastases in this region, usually in patients aged 40 to 70 years.Case Report: We present a patient aged 79 years with a tumour change in the body of the tongue. After histopathological and immunohistochemical analysis (Cytokeratin, Vimentin, CD 10 positive tumour cells, Cytokeratin 7, Cytokeratin 20 negative tumour cells), there was a suspicion of metastasis of clear cell renal carcinoma (CCRC). Due to renal cancer, the patient had left kidney operated seven years before the diagnosis of tongue tumour.Conclusions: Diagnosis of metastatic tumours of the oral region is a great challenge, both for clinicians and for histopathologists. Since it is a heterogeneous group of neoplasms, standard histopathological tissue processing, is not always sufficient to determine the histological type of tumour and its primary origin. In the analysis of metastatic tumours of the oral region, team work is important and careful clinical and histopathological assessment lead to definitive and accurate diagnosis.

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Metastasis to the oral soft tissues: A review of 412 cases

Cited by 53 publications

References 216 publications

Metastasis to the Jawbones: A review of 453 cases

Metastasis to the Jawbones: A review of 453 cases

Multiple gingival metastasis of renal cell carcinoma: a case report

Histopathological analysis of metastatic tumours of the oral cavity with example of metastatic renal cell carcinoma to tongue

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