2008
DOI: 10.1016/j.febslet.2008.02.013
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Metastasis tumor antigen 1 is involved in the resistance to heat stress‐induced testicular apoptosis

Abstract: Our previous study documented the expression of Mta1 during spermatogenesis. Here, we present evidence for a possible involvement of Mta1 in the regulation of testicular function, possibly by interacting with p53. A notable decrease of Mta1 expression was revealed at postsurgical day 6, consistent with the previously reported upregualtion of p53 in mouse cryptorchidism. Furthermore, in vitro over-expression of Mta1 could remarkably elevate the resistance capability of spermatogenic tumor cells against heat-ind… Show more

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Cited by 29 publications
(21 citation statements)
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“…The high-risk HPVs E6 protein bound to p53, promoting the degradation of p53 and thus weakening its function [25,26] . Recent data suggested that MTA1 might interact with p53, but there were controversial reports about its effect on p53 level [24,[27][28][29] . Our result was consistent with that reported by Li [27] .…”
Section: Discussionmentioning
confidence: 98%
“…The high-risk HPVs E6 protein bound to p53, promoting the degradation of p53 and thus weakening its function [25,26] . Recent data suggested that MTA1 might interact with p53, but there were controversial reports about its effect on p53 level [24,[27][28][29] . Our result was consistent with that reported by Li [27] .…”
Section: Discussionmentioning
confidence: 98%
“…Li et al described a stage-specific expression and localization of MTA1 during postnatal testis development and spermatogenesis, suggesting a possible role of MTA1 in these processes [21,22]. Moreover, these authors proposed that MTA1 contributed to the resistance of spermatogenic cells to heatinduced apoptosis [23,24]. MTA1 was upregulated after acute hepatic injury, and it is suggested that MTA1 may help to stimulate hepatic proliferation and differentiation during hepatic regeneration [25].…”
Section: Mta1 Subcellular Localization and Related Functionsmentioning
confidence: 96%
“…Additionally, it has been shown that in cryptorchid monkey testes, the testicular orphan receptor 2 (TR2) is repressed by P53 via cyclin D kinase and retinoblastoma signaling ( 59 ) . Li et al ( 60 ) showed that overexpression of metastasis tumor antigen 1 (MTA1) could reduce the expression of P53 and increase spermatogenic tumor cells' resistance against heat-induced apoptosis. In the cryptorchid mouse testis, MTA1 expression decreases with the increase of P53 expression.…”
Section: Apoptosis In Cryptorchidismmentioning
confidence: 99%