Metastasizing Leiomyoma to Heart

Consamus, Erin N.; Reardon, Michael J.; Ayala, Alberto G.; Schwartz, Mary R.; Ro, Jae Y.

doi:10.14797/mdcj-10-4-251

Cited by 24 publications

(30 citation statements)

References 14 publications

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“…Previous studies have reported these tumors often stain positively for both estrogen and progesterone receptors [8][9][10][11][12]. Our patient's cardiac mass was 95% and 20% immuno-reactive for estrogen and progesterone, respectively, consistent with a uterine origin.…”

Section: Resultssupporting

confidence: 49%

“…However, this study found no significant relationship between the type of primary surgery and BML diagnosis with respect to timing of surgery or site of metastasis. Three out of the four other recorded cases of BML to the heart had multiple lung metastases [7][8][9][10][11][12]. In these case reports, BML was found in the right atrium, interventricular septum, tricuspid valve and right ventricle [8].…”

Section: Resultsmentioning

confidence: 96%

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Benign Metastasizing Leiomyoma of the Heart

C¹,

Shrestha²,

Mark³

2018

Int J Clin Cardiol

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This is a rare case of a 53-year-old woman with history of oophorectomy and hysterectomy 3 years prior to presentation admitted for gait abnormality and found to have a basal ganglia stroke. Transthoracic echocardiogram for stroke work up revealed a cardiac mass in the right atrium emanating from Inferior Vena Cava (IVC). Computed Tomography imaging of abdomen and pelvis ruled out malignancy. The mass was surgically removed due to high risk of embolization. Intraoperative, transesophageal echocardiogram was negative for inter-atrial shunt. Pathology report revealed Benign Metastasizing Leiomyoma that was estrogen and progesterone hormone positive. CASe RepoRt abetes mellitus, and an abdominal hysterectomy with bilateral salpingo-oophorectomy which was performed three years prior for symptomatic uterine leiomyoma. There was also a history of chronic pulmonary nodules dating back 8 years; prior biopsy of one of the nodules revealed a benign hamartoma. On her initial presentation, the physical exam was notable for a mild gait disturbance. Otherwise, there were no other abnormalities. Laboratory studies were normal. The electrocardiogram revealed sinus rhythm with 1 st degree AV Block. Chest x-ray showed unchanged pulmonary nodules. A magnetic resonance imaging (MRI) of the brain showed a left basal ganglia infarct with extension to the periventricular white matter (Figure 1). Chest computed tomography angiography (CTA) ruled out pulmonary embolism as a cause for the dyspnea. The CTA also demonstrated multiple pulmonary nodules in the right upper and left upper lobes that had Check for updates

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Section: Resultssupporting

confidence: 49%

Section: Resultsmentioning

confidence: 96%

Benign Metastasizing Leiomyoma of the Heart

C¹,

Shrestha²,

Mark³

2018

Int J Clin Cardiol

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“…The term of BML is now used to describe the presence of histologically benign smooth muscle tumors in extra-uterine sites with the coexistence or previous removal of a uterine leiomyoma ( Awonuga et al, 2010 ). BMLs most commonly occur in the lung, but have been reported in the lymph nodes, mediastinum, heart, retroperitoneum, brain, and bones ( Consamus et al, 2014 ; Jo et al, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Case of pulmonary benign metastasizing leiomyoma from synchronous uterine leiomyoma in a postmenopausal woman

Baek

2018

Gynecologic Oncology Reports

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Benign metastasizing leiomyoma (BML) is a rare tumor comprising histologically benign smooth muscle cells and exhibits the same histological findings as a uterine myoma although in an extra-uterine location. Most BMLs occur several years after surgery for uterine myoma in women of reproductive age. Here, we report a case of pulmonary BML in a 54-year-old postmenopausal woman with no previous history of myomectomy or hysterectomy. The patient presented with a rapid increase in abdominal girth over the past 3 months and a cough lasting for 2 months. Chest computed tomography (CT) revealed multiple pulmonary nodules, ranging in diameter from a few millimeters to 1.5 cm. Abdominal CT revealed a well-defined heterogeneous hypervascular uterine mass measuring 25 cm at the widest diameter. In addition to the uterine mass, imaging studies identified no other origin of the metastatic lung nodules. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed followed by video-assisted thoracoscopy. The histological findings of the lungs and uterus suggested myoma. The patient remains asymptomatic and disease-free at 7 years after surgery without adjuvant treatment.

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“…While several cases of cardiac metastases have been reported with IVL [ 12 , 16 ], to our knowledge, this is only the 5th case of BML metastasizing to the heart reported in the literature [ 17 – 20 ]. All previously reported cases had a history of hysterectomy up to 16 years prior to cardiac metastases.…”

Section: Discussionmentioning

confidence: 99%

The Heart as a Site of Metastasis of Benign Metastasizing Leiomyoma: Case Report and Review of the Literature

Meddeb

Chow

Whipps

et al. 2018

Case Reports in Cardiology

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Uterine leiomyomas are the most common gynecological tumors in premenopausal women. While the lung is the most common extrauterine organ afflicted, benign metastasizing leiomyomas (BML) of the heart are rarities. We report an incidental finding of a cardiac mass in a 36-year-old woman who presented to the Emergency Department after a motor vehicle accident. CT scan of the chest revealed 2 well-circumscribed pulmonary nodules and a filling defect in the right ventricle. Echocardiogram showed a 4 cm mass attached to the right ventricular (RV) septum. The cardiac tumor was resected and showed benign histologic features. Immunohistochemical staining was positive for smooth muscle α-actin and desmin, as well as estrogen and progesterone receptors, consistent with the diagnosis of uterine leiomyoma.

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Metastasizing Leiomyoma to Heart

Cited by 24 publications

References 14 publications

Benign Metastasizing Leiomyoma of the Heart

Benign Metastasizing Leiomyoma of the Heart

Case of pulmonary benign metastasizing leiomyoma from synchronous uterine leiomyoma in a postmenopausal woman

The Heart as a Site of Metastasis of Benign Metastasizing Leiomyoma: Case Report and Review of the Literature

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