Metastasizing Pleomorphic Adenoma with Myoepithelial Cell Predominance

Cresson, David H.; Goldsmith, Manning M.; Askin, Frederic B.; Reddick, Robert L.; Postma, Duncan S.; Siegal, Gene P.

doi:10.1016/s0344-0338(11)80273-6

Cited by 23 publications

(5 citation statements)

References 23 publications

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“…1,4 It is suggested that myoepithelial cell proliferation within the tumor may predict an aggressive nature of lesion. 5 Nevertheless, local recurrence of the disease prior to appearance of metastatic lesions has been a consistent observation in the clinical behavior of these tumors. 1,2 The tumor reported here could be considered as locally aggressive type, the recurrence having occurred due to either incomplete excision or tumor spillage during the earlier surgery.…”

Section: Discussionmentioning

confidence: 94%

“…Tumor ploidy and the presence of intravascular tumor in pleomorphic adenomas have not correlated with future development of metastases 1,4 . It is suggested that myoepithelial cell proliferation within the tumor may predict an aggressive nature of lesion 5 . Nevertheless, local recurrence of the disease prior to appearance of metastatic lesions has been a consistent observation in the clinical behavior of these tumors 1,2 .…”

Section: Discussionmentioning

confidence: 99%

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Histologically Benign Pleomorphic Adenoma of Parotid with Subcutaneous Metastases

Muthusami¹,

Jesudason²,

Jesudason³

et al. 2005

Otolaryngol.--head neck surg.

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P leomorphic adenoma is a benign salivary gland with potential for malignant transformation. When the malignant transformation occurs, the tumor develops a tendency for local recurrence and distant metastases and the histology of the tumor reflects all the cellular features of malignancy. However, there is an entity of pleomorphic adenoma which, while retaining benign histological features, tends to develop both local and distant recurrences despite adequate clearance at primary surgery. The reason for this remains unexplained and there is no predictor for this behavior. The rarity of its occurrence and inadequacy of information about its treatment prompted us to report our experience with one such case.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Histologically Benign Pleomorphic Adenoma of Parotid with Subcutaneous Metastases

Muthusami¹,

Jesudason²,

Jesudason³

et al. 2005

Otolaryngol.--head neck surg.

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“…B enign mixed tumors are the most common neoplasm of salivary glands and are composed of an admixture of benign glandular epithelia and mesenchymal component such as myxochondroid, mucoid or hyalinized fibrous stroma 1,11) . Some of these 2-9% are known to undergo malignant change 3) . The malignant mixed tumors of salivary glands include carcinoma ex-mixed tumor and carcinosarcoma (true malignant mixed tumor).…”

Section: Discussionmentioning

confidence: 99%

“…Chen stated that infiltrative growth pattern and limited mitotic activity in an otherwise typical mixed tumor is indicative of MMT 1) . Cresson et al postulated that myoepithelial predominance should be considered in diagnostic criteria of MMT 3) . El-Naggar et al postulated that the only common feature to all MMT was stromal, often myxoid preponderance in the tumors 4) .…”

Section: Discussionmentioning

confidence: 99%

Craniospinal Metastasis from a Metastasizing Mixed Tumor of Salivary Gland : Unusual Presentation

Cho

Jeon

et al. 2007

J Korean Neurosurg Soc

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Metastasizing mixed tumors (MMT) of salivary glands are inexplicably metastasize maintaining benign histology. There is no pathologic and flow cytometric analysis criteria to predict the metastasis. MMT is known to metastasize by local implantation, vascular and lymphatic embolization after multiple surgery to local recurrences of primary tumor. However, multiple metastasis including cranium and spine occurred even without surgery to the primary tumor in this case. No pathological evidence of malignancy could be found in both primary and metastatic tumor. MMT is considered as an low grade malignancy based on clinical behavior rather than histologic evidence, such as low mortality rate, long delay of metastasis after primary lesion. Cranial metastasis is also extremely rare and only two cases have been reported. We report this unusual case with a literature review.

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“…Pleomorphic adenoma (PA) is the most common benign gland tumour, with an annual incidence of approximately 2.4–4.9/100 000, accounting for 71% of all salivary gland neoplasms 1,2 . Otherwise, PA has complicated biological characteristics such as capsular invasion, with a crucial role in its surgical decision‐making and postoperative recurrence.…”

Section: Introductionmentioning

confidence: 99%

Expression of cartilage oligomeric matrix protein (COMP) associates with capsular invasion in salivary gland pleomorphic adenoma

Yao

Guan

Lin

et al. 2022

J Oral Pathology Medicine

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Background Accumulating evidence shows that pleomorphic adenoma (PA) exhibits a unique capsular invasion and with a crucial role in recurrence. This study was designed to explore RNA expression profiles in salivary gland PA in an attempt to further analyse genes associate with capsule invasion. Methods We evaluated the expression profiles of 4 salivary gland PA patients by RNA‐sequencing. The principal functions of the differentially expressed mRNAs (DEGs) were explored using GO and KEGG analysis. Then, RT‐qPCR and correlation analyses were performed to verify the candidate DEGs in 59 PA patients, and immunohistochemical examinations were conducted to validate candidate DEGs. Finally, the COMP‐related genes were screened using correlation and biological pathway enrichment analysis, and further validated by RT‐qPCR. Results A total of 974 DEGs were significantly upregulated, and 1464 were downregulated (fold change ≥2.0; p < 0.05). Based on GO and KEGG analyses, extracellular matrix organization and the PI3K‐Akt signalling pathway might play pivotal roles in the tumorigenesis of PA. 40 DEGs were screened and validated by RT‐qPCR, 11 upregulated and 5 downregulated DEGs were consistent with the sequencing results. Cartilage oligomeric matrix protein (COMP) was identified to have a significant correlation with the capsular invasion of PA and expression of COMP in patients with invasive capsular PA was significantly stronger than PA. Finally, further results could reveal that 5 highest scoring genes were screened as hub genes for COMP. Conclusions These findings suggested that COMP may be a prognostic target for PA and might contribute to its capsular invasion.

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Metastasizing Pleomorphic Adenoma with Myoepithelial Cell Predominance

Cited by 23 publications

References 23 publications

Histologically Benign Pleomorphic Adenoma of Parotid with Subcutaneous Metastases

Histologically Benign Pleomorphic Adenoma of Parotid with Subcutaneous Metastases

Craniospinal Metastasis from a Metastasizing Mixed Tumor of Salivary Gland : Unusual Presentation

Expression of cartilage oligomeric matrix protein (COMP) associates with capsular invasion in salivary gland pleomorphic adenoma

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