Metastasizing squamous cell carcinoma arising from chronic discoid lupus erythematosus plaque of recent onset

Discoid lupus erythematosus leading to squamous cell carcinoma: a case report

“…[3][4][5] But in contrast, Tao et al found more patients of localized DLE developing SCC which is similar to our case report. 6 In a review by Sherman et al, the interval between development of DLE and SCC has varied from 4-20 years.…”

Atypical Fibroxanthoma Arising in a Scar of Discoid Lupus Erythematosus

“…5,8 However, this explicative model is hardly applicable in those cases in which the tum or arises in lesions of DLE in a sun-protected area.9 Genetic predis position, severity of DLE, and human papillomavirus infection of discoid lesions are other hypothesized secondary factors. 4,8,9 Furthermore, some authors have also speculated on a hypothetical, but indeterminate, contribution of the chronic scarring process.8 This, together with chronic inflammation per se, has also been considered a possible causal factor for the development of soft tissue sarcomas from DLE, by unknown mechanisms. 6 In general, scars of various origin are common vulnerable areas for the subsequent development of cutaneous tumors, including AFX, 10,11 and according to recent studies, such an event would be due to the interruption of the normal innervation and lymphatic network occurring in scarring sites, with a consequent imbalance of lymphatic circulation and release of neuromediators.…”

Cutaneous squamous cell carcinoma causing a rhinophymatous mass in a patient with clinically occult hypertrophic lupus erythematosus

“…6 One commonality these cases share is equivocal diagnosis at initial biopsy. 9,10,11 Authors have reported an aggressive clinical history for cSCC arising in a background of DLE. 9,12 Most cases arise in a patient with greater than 5 years of DLE.…”