Metastatic Adenoid Cystic Carcinoma Mimicking Butterfly Glioblastoma: A Rare Presentation in the Splenium of the Corpus Callosum

Garber, Sarah T.; Khoury, Laith; Bell, Diana; Schomer, Donald F.; Janků, Filip; McCutcheon, Ian E.

doi:10.1016/j.wneu.2016.07.111

Cited by 8 publications

(9 citation statements)

References 39 publications

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“…Programmed cell death ligand 1 immunostaining was performed and revealed 0% membranous staining. In another case, 34 PD-1 inhibitor pembrolizumab was used in combination with radiotherapy to treat ACC of the parotid gland that had metastasized to the brain; the long-term outcome in this case is unknown.…”

Section: Discussionmentioning

confidence: 99%

PD-L1 and PD-L2 Expression Levels Are Low in Primary and Secondary Adenoid Cystic Carcinomas of the Orbit: Therapeutic Implications

Wolkow

Afrogheh

Kidd

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose-To determine if there is a biologic rationale for using checkpoint inhibitor drugs targeting programmed cell death ligand 1 (PD-L1) and PD-L2 in the treatment of adenoid cystic carcinoma of the orbit.Methods-Twenty-three cases of adenoid cystic carcinoma involving the orbit (13 primary lacrimal gland, 5 secondarily extending into the orbit, and 5 unspecified) were examined histopathologically. Immunohistochemistry for PD-L1, PD-L2, and CD8 was performed. Charts were reviewed for clinical correlations.Results-Expression of PD-L1 and of PD-L2 was overall low in adenoid cystic carcinoma (mean expression 1.4?±0.

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Section: Discussionmentioning

confidence: 99%

PD-L1 and PD-L2 Expression Levels Are Low in Primary and Secondary Adenoid Cystic Carcinomas of the Orbit: Therapeutic Implications

Wolkow

Afrogheh

Kidd

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…The primary treatment for metastatic ACC is surgical resection followed by adjuvant radiotherapy [1], however, for multiple brain metastasis as in our current case, we preferred to make a stereotaxic biopsy of accessible brain lesion to confirm the diagnosis and send the patient for radiotherapy and chemotherapy for the lung progression mass.…”

Section: Discussionmentioning

confidence: 96%

“…Adenoid cyst carcinoma was reported for the parotid gland, Bartholin's gland, and Breast, the metastisation are been reported for the Brain, the kidney, lung, and pituitary [1][2][3][4][5][6][7]. The most common secondary location of thyroid ACC is the lung (20%) followed by the bones (4%) and the liver (3%), the brain location is scantly reported [8,9].…”

Section: Discussionmentioning

confidence: 99%

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Brain metastasis of thyroid adenoid cyst carcinoma: Unusual case report

Hemama¹,

Bankole²

2022

J Clin Images Med Case Rep

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Background: Cerebral metastasis from Adenoid cyst Carcinoma (ACC) remains extremely rare. Case description: 62-year-old female, with a history of thyroidectomy for goiter surgery associated with left cervical lymphadenopathy five years ago. She presented a decrease in visual acuity at 6/10 in the right eye. Brain MRI revealed an intra-conical right orbital lesion process associated with a right frontal cerebral lesion process, three other osteolytic lesions of the cranial vault, lung metastases, and hepatic metastasis. Thyroid ACC with Antibody Anti CD117+ after stereotaxic biopsy of brain lesion was retained by the pathologist. She underwent radiotherapy and chemotherapy management. At 6 months follow-up, the cerebral and liver localisations didn’t progress, unfortunately, the lung mass was progressed from 4 cm to 6 cm. Conclusion: Multiple brain metastasis from ACC of the thyroid is extremely rare. Diagnosis and Management could present some challenges for surgeons and oncologists Keywords: Adenoid cyst carcinoma; Thyroid; Brain metastasis; CD117; Stereotaxic biopsy.

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“…A number of pathologies those involve corpus callosum can mimic butterfly glioblastomas including other lesser grade variants of gliomas involving corpus callosum, [22][23][24][25] lymphoma, metastasis, [26] toxoplasmosis, [27] demyelinating butterfly pseudo glioma, [28] and neuronal ceroid-lipofuscinosis (Kufs' disease) [29] because of its multiplanar capability, MRI with contrast enhancement and FLAIR sequence [7,18] can help to differentiate these lesions from each other; however, in doubtful cases the biopsy shall help to make the diagnosis.…”

Section: Differential Diagnosismentioning

confidence: 99%

Perspective Chapter: Glioblastoma of the Corpus Callosum

Kunwar¹,

Maurya²,

Deivasigamani³

et al. 2023

Glioblastoma - Current Evidence

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Glioma is the most common malignant tumour of the brain, in which glioblastoma (GBM) is the most aggressive form which infiltrates through the white fibre tracts. Corpus callosum (CC) is most invaded by GBM, it carries poor prognosis as mostly these tumours are not touched upon due to the belief of post operative cognitive decline, or there is incomplete resection leading to tumour recurrence. However current advancement in technology, operative techniques and better understanding of nature of CC-GBM, maximal safe resection is being carried out with better outcomes in comparison with the GBM without infiltration of CC.

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Metastatic Adenoid Cystic Carcinoma Mimicking Butterfly Glioblastoma: A Rare Presentation in the Splenium of the Corpus Callosum

Cited by 8 publications

References 39 publications

PD-L1 and PD-L2 Expression Levels Are Low in Primary and Secondary Adenoid Cystic Carcinomas of the Orbit: Therapeutic Implications

PD-L1 and PD-L2 Expression Levels Are Low in Primary and Secondary Adenoid Cystic Carcinomas of the Orbit: Therapeutic Implications

Brain metastasis of thyroid adenoid cyst carcinoma: Unusual case report

Perspective Chapter: Glioblastoma of the Corpus Callosum

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