Metastatic Angiosarcoma and Kasabach-Merritt Syndrome

Massarweh, Suleiman; Munis, Aun; Karabakhtsian, Rouzan G.; Romond, Edward H.; Moss, Jessica

doi:10.4081/rt.2014.5366

Cited by 11 publications

(4 citation statements)

References 15 publications

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“…While KMS is commonly seen in infants with Kaposiform haemangioendothelioma,19 it can also occur in adults with angiosarcoma, although this is rare. Despite treatment, most patients with KMS die rapidly, although there have been a few reports of longer survival after receiving paclitaxel-based therapy 20–23…”

Section: Discussionmentioning

confidence: 99%

Recurrent metastatic angiosarcoma presenting as Kasabach-Merritt syndrome

Dhabhar

Team

2023

BMJ Case Rep

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Angiosarcoma is an incredibly rare type of malignancy, accounting for only 1%–2% of all soft-tissue sarcomas globally. It is clinically, pathologically and radiologically difficult to diagnose angiosarcoma owing to its varied presentation with little or no well-defined imaging findings.Kasabach-Merritt syndrome is also a lesser-heard entity which carries extremely poor prognosis. It is primarily seen in infants with vascular malformations and in kaposiform haemangioendothelioma. It is a condition of consumptive coagulopathy and only few of the cases have been reported so far in the adults with a background of angiosarcoma.This report presents the case of a male in his 70s who was diagnosed with metastatic angiosarcoma and experienced a complicated disease course due to Kasabach-Merritt syndrome.

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Section: Discussionmentioning

confidence: 99%

Recurrent metastatic angiosarcoma presenting as Kasabach-Merritt syndrome

Dhabhar

Team

2023

BMJ Case Rep

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“…Moreover, rare presentations of PHA in cases of acute liver failure, high-output heart failure, esophageal varices, hemothorax, and disseminated intravascular coagulopathy from Kasabach-Merritt syndrome have recently been reported [12].…”

Section: Discussionmentioning

confidence: 99%

Primary Hepatic Angiosarcoma: A Rare Liver Malignancy – Varying Manifestations but Grave Prognosis

Rujeerapaiboon

Wetwittayakhlang²

2020

Case Rep Gastroenterol

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Primary hepatic angiosarcoma (PHA) is a rare mesenchymal liver tumor, accounting for 0.1-2% of primary liver malignancies. The clinical presentations of PHA are variable, from asymptomatic to liver failure or complicated with tumor rupture. The diagnosis of PHA is difficult due to the lack of specific clinical manifestation and investigation results, which can be confused with other liver tumors resulting in late diagnosis. However, there is currently a paucity of effective therapeutic approaches. We advocate early diagnosis with radiological imaging and histopathology because most of them are diagnosed in late-stage and carry a grave prognosis. Surgical resection remains the mainstay of treatment, which can significantly prolong survival. Chemotherapy, including transarterial chemoembolization, is an option for palliative treatment. Unfortunately, molecular treatment has limited efficacy and liver transplantation is also not recommended due to high rate of recurrence. We present a case series of four patients with biopsy-proven PHA which had distinct presentations and clinical courses.

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“…There have been a few reported cases of angiosarcoma with coagulation abnormalities including disseminated intravascular coagulation (DIC) [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. In one report, 7 (16.7%) of 42 patients who had angiosarcoma were diagnosed as having DIC [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Cardiac Angiosarcoma Associated with Disseminated Intravascular Coagulation with Nab-Paclitaxel: A Case Report and Review of the Literature

Honda¹,

Ando²,

Sugiyama³

et al. 2017

Case Rep Oncol

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Angiosarcoma of the heart is an uncommon soft tissue sarcoma. A few cases of disseminated intravascular coagulation (DIC) associated with angiosarcoma occurring in various organs, but not the heart, have been reported. Although taxane is commonly used in the treatment of metastatic angiosarcoma, data on the efficacy of nab-paclitaxel for angiosarcoma are limited. Here, we report probably the first case of a patient with primary cardiac angiosarcoma with coexisting DIC who was successfully treated with nab-paclitaxel. A 62-year-old female with chief complaints of nausea and shortness of breath was diagnosed as having cardiac angiosarcoma with liver metastases. Four months after the resection of her primary tumor, the hepatic metastatic lesions progressed rapidly accompanied by new metastatic lesions in the right iliac bone and signs of DIC. She received nab-paclitaxel as first-line chemotherapy. A response of stable disease was achieved after 2 treatment cycles and DIC was successfully controlled for at least 4 months. This report suggests potential utility of nab-paclitaxel for angiosarcoma complicated with DIC. We also review the literature for all cases of angiosarcoma with DIC reported so far.

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Metastatic Angiosarcoma and Kasabach-Merritt Syndrome

Cited by 11 publications

References 15 publications

Recurrent metastatic angiosarcoma presenting as Kasabach-Merritt syndrome

Recurrent metastatic angiosarcoma presenting as Kasabach-Merritt syndrome

Primary Hepatic Angiosarcoma: A Rare Liver Malignancy – Varying Manifestations but Grave Prognosis

Successful Treatment of Cardiac Angiosarcoma Associated with Disseminated Intravascular Coagulation with Nab-Paclitaxel: A Case Report and Review of the Literature

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