Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall

Gupta, A. S.; Patel, Trupti; Dargar, Parul; Shah, Manoj

doi:10.4103/0970-9371.112659

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…Goblet cell carcinoid (GCC), an unique and enigmatic tumor involving the appendix almost exclusively, is a rare variant of appendiceal carcinoid [ 10 ]. Carcinoid tumors account for up to 85% of all appendiceal tumors, white, GCC accounts for only 6% of all appendiceal carcinoid tumors [ 11 ]. The term GCC was firstly introduced by Subbuswamy et al in 1974 [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Intestinal goblet cell carcinoid presenting with recurrent sterile peritonitis in a patient on peritoneal dialysis: a case report

et al. 2017

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BackgroundGoblet cell carcinoid is a rare variant of appendiceal carcinoid with mixed endocrine and exocrine features. The most common symptom and signs are abdominal pain, acute appendicitis and palpable mass. Additionally, abdominal pain is common in patient on peritoneal dialysis, which may confound the diagnosis in such patient.Case presentationWe report a 71- years- old woman on peritoneal dialysis that experienced several episodes of abdominal cramping pain and sterile peritonitis. She had one episode of severe pain and underwent an appendectomy for suspicion of appendicitis. Goblet cell carcinoid was diagnosed. She had no further abdominal pain after she received appendectomy.ConclusionsMalignant dialysate was rarely reported in patient with peritoneal dialysis. However, goblet cell carcinoid can initially present with acute appendicitis, chronic intermittent abdominal pain and mimicking peritonitis. In systemically reviewing the literature, this is the first case report of sterile peritonitis with peritoneal dialysis caused by goblet cell carcinoid.

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Section: Discussionmentioning

confidence: 99%

Intestinal goblet cell carcinoid presenting with recurrent sterile peritonitis in a patient on peritoneal dialysis: a case report

et al. 2017

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“…There have been several reports of metastatic GCC in effusion, and a few types of cells have been described. A common characteristic is signet‐ring cells with abundant cytoplasm and displaced nuclei.…”

Section: Discussionmentioning

confidence: 99%

“…A common characteristic is signet‐ring cells with abundant cytoplasm and displaced nuclei. Gupta et al reported small cells in addition to signet‐ring cells; because of a background of mucin, they considered the tumor to be a metastatic mucinous carcinoma . Zafar et al described two types of cells other than signet‐ring‐like cells: small to intermediate size cells, and larger cells.…”

Section: Discussionmentioning

confidence: 99%

Cytological findings of appendiceal mixed adenoneuroendocrine carcinoma in pleural effusion: Morphological changes evident after metastasis

Tonooka

Oda

Hayashi

et al. 2014

Diagnostic Cytopathology

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Goblet cell carcinoid (GCC) of the appendix is now regarded as a malignant tumor, and mixed adenoneuroendocrine carcinoma (MANEC) is a carcinoma progressing from GCC. We describe a man initially diagnosed with GCC of the appendix who died 4 years after diagnosis. Pleural fluid due to metastasis was noted in the terminal phase. Histological findings of the initial tumor indicated that cells with signet-ring morphology were predominant, but the cytological morphology of the fluid was more atypical, making it difficult to diagnose as metastatic GCC by cellular morphology alone. The cells in the pleural fluid were immunopositive for synaptophysin, which was compatible with GCC, but p53 and ki67 staining indicated that the metastatic tumor was more aggressive. These findings suggested a final diagnosis of poorly differentiated adenocarcinoma-type MANEC, which we define as a tumor with typical GCC characteristics and foci that cannot be distinguished from a poorly differentiated adenocarcinoma. This case, which we believe is reported here for the first time, indicates the cytological features of GCC cells may change at metastatic sites to be more atypical and aggressive as the tumor progresses, and these changes should be considered in diagnosis.

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“…There are rare cases of ostensibly primary extra-appendiceal GCC have been reported as stomach, duodenum, ampulla of Vater (21), jejunum, ileum, cecum, splenic flexure (22,23), ascending colon (24) and rectum (22,25,26,27,28).…”

Section: Mcdole Et Al From Washington University Inmentioning

confidence: 99%

Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature

Abdalla¹,

Khan²,

Shah³

et al. 2020

chr

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Carcinoizii cu celule goblet (GCC) sunt tumori neuroendocrine extrem de rare şi sunt caracterizate prin combinaţia lor unică de două tipuri de celule canceroase -neuroendocrine (carcinoide) şi epiteliale (adenocarcinom). În ciuda faptului că GCC este considerată tumoră neuro-endocrină (NET), nu prezintă sindromul carcinoid ilicit. GCC apare de obicei în anexă şi reprezintă mai puţin de 14% din toate tumorile apendiceale. GCC extraapendiceal primar a fost raportat la stomac, duoden, intestinul subţire, colon şi rect. Lucrarea prezintă un caz rar de GCC a colonului ascendent la un bărbat de 57 de ani.Cuvinte cheie: carcinoid cu celule goblet, tumori neuroendocrine, glandă apocrină, celule care prezintă antigen

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Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall

Cited by 6 publications

References 8 publications

Intestinal goblet cell carcinoid presenting with recurrent sterile peritonitis in a patient on peritoneal dialysis: a case report

Intestinal goblet cell carcinoid presenting with recurrent sterile peritonitis in a patient on peritoneal dialysis: a case report

Cytological findings of appendiceal mixed adenoneuroendocrine carcinoma in pleural effusion: Morphological changes evident after metastasis

Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature

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