Metastatic Balloon Cell Melanoma in a Dog

Wilkerson, Melinda J.; Dolce, Karen; DeBey, Brad M.; Heeb, Heather; Davidson, Harriet J.

doi:10.1111/j.1939-165x.2003.tb00310.x

Cited by 18 publications

(12 citation statements)

References 21 publications

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“…Several other cutaneous and subcutaneous tumors, including balloon cell melanoma, liposarcoma, and, infrequently, clear‐cell basal cell carcinoma, share some histologic features with sebaceous adenocarcinoma 14. Balloon cell melanoma and liposarcoma were ruled out in this case based on negative staining for Melan‐A and vimentin, respectively, and positive staining for pancytokeratin 15. The histopathologic sections of the tumor revealed sheets of cells that stained positive for pancytokeratin adjacent to sheets of nonneoplastic cells that were negative for pancytokeratin.…”

Section: Discussionmentioning

confidence: 94%

Cutaneous mass aspirate from a Golden Retriever: “glandular guile”

Dickinson¹,

Young²

2005

Veterinary Clinical Pathol

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A 3-year-old, neutered male Golden Retriever was presented to the University of Wisconsin-Madison Veterinary Medical Teaching Hospital (VMTH) for evaluation of a cutaneous mass located over the left cranial thorax. The mass was an incidental finding by the owner, and its duration was unknown. The dog had been presented to the VMTH twice in the previous year: once for elective castration and once for a single episode of diarrhea. No cutaneous masses had been found during the previous physical examinations.The mass was 10 3 9 3 5 mm and was firm, non-ulcerated, red, raised, and nonpruritic. Regional lymphadenopathy was absent, and there were no other clinical signs. Fine-needle aspiration of the mass was performed, and the specimen was submitted for cytologic evaluation (Figure 1). Based on the cytologic findings, thoracic radiographs were taken, and excisional biopsy of the mass was performed.(Continued on next page) Figure 1. (A-C) Three areas from a fine-needle aspirate of a cutaneous mass from a dog. Modified Wright's, 360 objective.The sample was highly cellular with large numbers of pleomorphic, individualized, round to polygonal cells having variable N:C ratios (Figure 1). Anisocytosis and anisokaryosis were marked. Cell margins typically were distinct. The cytoplasm was basophilic and finely granular with occasional cells containing a prominent, perinuclear clear zone. A few cells contained small numbers of clear vacuoles, and infrequently, cells had intracytoplasmic secretory vacuoles. Rarely, large cells contained other similar intact cells ( Figure 1C), and rare cells had a moderate amount of amorphous, magenta, glassy material within the cytoplasm. Nuclei had fine chromatin with multiple prominent nucleoli that varied markedly in size and shape. Multinucleated cells were found in moderate numbers, and there was marked variation of nuclear size within the same cell. Mitotic figures, including bizarre forms, were found in small numbers, and rarely, mitotic figures coexisted with intact nuclei within a multinucleated cell. There were a few small cellular aggregates with an acinarlike appearance. Cytoplasmic debris from ruptured cells and clear droplets were present. The background contained small numbers of nondegenerate neutrophils and vacuolated macrophages. The cytologic interpretation was malignant tumor with mild, mixed inflammation. With the exception of occasional acinar-like formations, the features were most typical of a tumor of mesenchymal origin. Differential diagnoses included liposarcoma, atypical amelanotic (balloon cell) melanoma, anaplastic sarcoma, and anaplastic carcinoma.

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Section: Discussionmentioning

confidence: 94%

Cutaneous mass aspirate from a Golden Retriever: “glandular guile”

Dickinson¹,

Young²

2005

Veterinary Clinical Pathol

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“…Balloon cell melanomas, clear cell carcinomas, and sebaceous adenocarcinomas have been described in dogs, which show distinct cells with cytoplasmic vacuoles and eosinophilic stippling in a proteinaceous background on cytology. However, the cells of these tumors display increased atypia (ie, moderate to marked anisokaryosis, multinucleation, coarse chromatin, and large nucleoli) 12‐14 . Rhabdomyomas, granular cell tumors, and oncocytomas can also exfoliate as round cells with pink cytoplasmic material.…”

Section: Discussionmentioning

confidence: 99%

Cytologic appearance of hibernoma in two dogs

Piccione

Dial

2020

Veterinary Clinical Pathol

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Hibernomas are rare benign tumors of brown fat (adipose tissue) that have been reported in several different species. The cytologic characterization of these tumors has not been described in dogs. In this case report, we describe two dogs with hibernomas, focusing on the cytologic appearance of these unique neoplasms. Both cytologic specimens were highly cellular and predominated by vacuolated neoplastic cells with no evidence of concurrent inflammation. The cells contained a moderate to large number of variably sized cytoplasmic vacuoles, with occasional, irregularly shaped pink granular material. Most cells contained a single nucleus; however, cells displayed moderate anisokaryosis. A biopsy with histologic examination was performed in both cases, confirming the cytologic suspicion of hibernoma. Immunohistochemistry revealed that both tumors were positive for UCP1 and vimentin, and negative for cytokeratin. Hibernoma is an important differential diagnosis in dogs with conjunctival and periocular swellings that exfoliate numerous, mildly atypical, vacuolated cells.

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“…Other tumors that have been reported to be metastatic in dogs include lymphosarcoma, 7,25 osteosarcoma, 26 hemangiosarcoma, 27 transitional cell carcinoma, 28 transmissible venereal tumor, 29,30 seminoma, 31 thyroid adenocarcinoma, 32 renal carcinoma, pancreatic adenocarcinoma, perianal neurofibrosarcoma, rhabdomyosarcoma, 33 mammary adenocarcinoma, 32,34 nasal adenocarcinoma, 35 and melanoma 33,36,37 . Digital, 37–39 oral 36 and lip 33 melanoma have been reported to be metastatic to the uvea in the dog. Confirmed cases of metastatic malignant melanoma in the COPLOW collection most often originate from the oral cavity or digits.…”

Section: Discussionmentioning

confidence: 99%

Suspected uveal metastasis of a nail bed melanoma in a dog

Esson¹,

Fahrer²,

Zarfoss³

et al. 2007

Veterinary Ophthalmology

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A 13-year-old Golden Retriever was referred for evaluation of generalized corneal edema, dyscoria, and suspected glaucoma affecting the right eye. The dog exhibited no signs of systemic illness, but had a history of a melanoma of the nail bed of the first digit of the right hind limb, excised 1 year previously. Ophthalmologic examination revealed diffuse corneal edema, mild anterior uveitis, glaucoma and a mass within the right iris. Enucleation was performed and histopathologic evaluation of the globe revealed the iris to be infiltrated with an anaplastic melanoma, suspected to represent a metastasis of the original nail bed tumor.

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Metastatic Balloon Cell Melanoma in a Dog

Abstract: Immunohistochemical staining and ultrastructural features of the neoplastic cells supported a diagnosis of metastatic balloon cell melanoma.

Cited by 18 publications

References 21 publications

Cutaneous mass aspirate from a Golden Retriever: “glandular guile”

Cutaneous mass aspirate from a Golden Retriever: “glandular guile”

Cytologic appearance of hibernoma in two dogs

Suspected uveal metastasis of a nail bed melanoma in a dog

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