Metastatic cancer of unknown primary site

A case of inguinal lymph node squamous cell carcinoma of unknown origin, accompanied with carcinoma in situ of cervix

“…CA125 was 48.83 IU/ml, CA19-9 was ＜1 IU/ml, CEA was 6.43 ng/ml, AFP was 1.68 ng/ml, and SCC was 0.44 ng/ml. In complete blood cell count, hemoglobin was 10.1 g/dl, hematocrit was 29.9%, white blood cell count was 7,300/mm 3 , and platelet count was 150,000/mm 3 . The results of other examinations, including urinalysis, liver function tests and renal function tests, revealed no abnormalities.…”

“…1,2 In the 1970s, some researchers argued that the diagnosis of CUP could be made only if the primary site could not be found even after an autopsy. 3 Today, the definition of CUP includes patients who present with histologically confirmed metastatic cancer in whom a detailed medical history, complete physical examination, full blood count and biochemistry, urinalysis and stool occult blood testing, histopathological review of biopsy material with the use of immunohistochemistry, chest radiography, computed tomography (CT) of the abdomen and pelvis and, in certain cases, mammography fail to identify the primary site. In the Mayor clinic, from 1984 to 1999, autopsy was performed on 64 patients who were diagnosed to be cancer with unknown origin, and the primary lesion could be found in only 35 patients (55%).…”

Multimodal Treatment for Multistation Mediastinal Lymph Node Adenocarcinoma: A Case Report

“…The frequency of all primary unknown cancers is reported at 0.5%-6.7%, [1][2][3] and mediastinal lymph node carcinoma constitutes 1.5% of these. 4) Twenty-five of the patients were male.…”

Lung Cancer Detected 5 Years after Resection of Cancer of Unknown Primary in a Mediastinal Lymph Node: A Case Report and Review of Relevant Cases from the Literature

“…[1][2][3] However, CUP of the thoracic lymph nodes (LNs) is comparatively rare, representing 1%-1.5% of all CUP cases. 1,4,5) It is typically difficult to detect the primary lesion even when a systemic, detailed evaluation is performed, and the primary site rarely becomes manifest during the long-term clinical course. Here, we report a rare and interesting case in which primary lung cancer was detected 5 years after resection of CUP of a mediastinal LN.…”