Metastatic Carcinoma of the Uterine Cervix from Rectal Carcinoma: A Case Report and Review of the Literature

Abstract

Primary adenocarcinomas of the uterine cervix account for 5% -15% of all cervical malignancies, but secondary adenocarcinomas from extragenital cancers are rare. Only 35 cases have been reported in the literature since 1941. We report a 52-year-old Japanese woman who had been treated for rectal adenocarcinoma (Dukes C, stage IIIb) and who was diagnosed with primary uterine cervical carcinoma (FIGO stage Ib2) two years later. A radical hysterectomy was performed and the surgical specimen showed metastatic adenocarcinoma of the uterine cervix from rectal cancer without direct extension. Immunohistochemical staining was positive for cytokeratin 20 and CDX2, and negative for cytokeratin 7. Immunohistochemical staining is important for distinguishing between primary and secondary adenocarcinomas of the cervix, but histologic findings alone are not always adequate to establish the site of the primary lesion. The distinction between primary and secondary adenocarcinomas of the cervix is important for patient management and prognosis. Therefore, the possibility of metastatic adenocarcinoma should be considered whenever a diagnosis of adenocarcinoma of the cervix is received. KeywordsMetastatic Adenocarcinoma, Cervical Cancer, Colorectal Carcinoma M. Matsuura et al. 618

Isolated Metastases to Multiple Genital Organs: a Curious Case of Metachronous Spread of Carcinoma Colon

“…Secondaries to the uterine cervix from extragenital sites are very rare comprising about 3.4% of cases of metastasis to female genital tract [7]. In a recent review by Matsuura, only 35 cases of secondary adenocarcinoma of the uterine cervix of extragenital primaries were reported in literature with colorectal carcinomas comprising 18.5% of them [8]. Reasons for infrequent involvement had been stated as high fibrous content, small size and limited blood flow, centrifugal lymphatic drainage, and infrequent diagnosis in patients already diagnosed with extragenital primary tumor.…”

Current approach to metastasis of extra-genital system malignancies to the female genital tract

“…Primer tümör ile serviks metastazı arasında ortalama 17 ay (0-60) vardır [26]. Serviks adenokarsinom metastazlarının % 18'i kolon adenokanserinin metastazıdır [27]. Kolorektal karsinomun serviks metastazı genelde tanıdan itibaren 5 yıl içinde meydana gelir [27].…”

“…Serviks adenokarsinom metastazlarının % 18'i kolon adenokanserinin metastazıdır [27]. Kolorektal karsinomun serviks metastazı genelde tanıdan itibaren 5 yıl içinde meydana gelir [27]. Tedavide histerektomi ve bilateral salfingoooferektomi yapıldıktan sonra KT olarak oksaliplatin, 5-flouraurasil ve folfoks verilebilir [27] .…”