Metastatic Carcinomas to the Oral Cavity and Oropharynx

Abstract

BackgroundMetastases to the oral/oropharynx are very rare and their diagnosis is challenging.MethodsWe reviewed pathologic data for malignant tumors of the oral/oropharynx that were diagnosed at the Asan Medical Center, Seoul, Korea from 1995 until 2010.ResultsTwenty-nine cases of oral/oropharyngeal metastases were retrieved, comprising 2.0% of 1,445 malignancies. The most common primary sites were the liver and lung, followed by the stomach, colon, breast, prostate, and kidney. The gingiva was the most common metastatic site, followed by the tonsil/pillar, mandible, tongue, tongue base, palate mucosa, mouth floor, and buccal mucosa. Intervals between detection of primary tumors and metastases were variable, from -1 month to 104 months. Ten patients with lung (7 cases), liver, stomach, and kidney carcinomas manifested with oral/oropharyngeal metastases as the first sign of systemic metastases. The majority of patients had died within one year of the onset of an oral/oropharyngeal metastasis, but exceptionally long-lived cases were also present. The survival periods of patients with lung cancers were longer than those of patients with non-pulmonary tumors.ConclusionsAn awareness of the incidence, common primary sites, metastatic subsites, and metastatic courses or patterns of oral/oropharyngeal metastases is helpful in the diagnosis of metastatic carcinomas.

Primary Lingual Colonic-Type Adenocarcinoma: A Rare and Emerging Distinct Entity!

“…Metastatic disease to the oral cavity is an uncommon occurrence. In a study of 1455 oropharyngeal malignancies, 2.0 % were metastatic disease and of those, only 2 (0.01 %) were of colorectal origin [13]. Among the 218 cases of oral mucosal metastatic disease reported by Hirshberg et al [14] 12 (5.5 %) were of colorectal origin.…”

A Case of Hepatocellular Carcinoma Presenting as a Gingival Mass

“…The liver was one of the most common primary site in that study, suggesting it could be possible due to high incidence of HCC in Korea. 13 In our patient, despite abnormal coagulation parameters, a biopsy of the oral mass was performed without any major complications. The growth of this oral mass was continuous with eventual aggravation of bleeding and pain.…”

Clinical case of oropharyngeal metastasis of kidney cancer

“…Орофарингеальные метастазы возникают крайне редко и составляют примерно 1,0-1,5 % всех злокаче-ственных опухолей полости рта и ротоглотки [1][2][3]. Так, в Медицинском центре Асан (Asan Medical Center, Сеул, Южная Корея) с 1995 по 2010 г. было зафиксировано 29 случаев орофарингеальных метастазов, что состави-ло 2,0 % от 1445 злокачественных новообразований данной локализации [1].…”

“…Так, в Медицинском центре Асан (Asan Medical Center, Сеул, Южная Корея) с 1995 по 2010 г. было зафиксировано 29 случаев орофарингеальных метастазов, что состави-ло 2,0 % от 1445 злокачественных новообразований данной локализации [1]. При этом метастатическое поражение костных структур (верхней и нижней челю-стей) не проявляется клинически и встречается чаще, чем метастазы в мягкие ткани (соотношение 2,5:1) [2,[4][5][6].…”

“…Но в 30 % случаев метастазы в мягкие ткани полости рта и ротоглотки -первое проявление отдаленного метастазирования. Интервал между обнаружением первичных опухолей и метаста-зов вариьрует от 1 до 104 мес [1].…”