Metastatic chordoma to the mandibular condyle: An anterior surgical approach

Meneghini, Fabio; Castellani, A.; Camelin, N.; Zanetti, Umberto

doi:10.1053/joms.2002.36133

Cited by 16 publications

(5 citation statements)

References 32 publications

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“…Interestingly, the sites of metastasis are clinically silent and may go undiagnosed for long periods of time. 11 In our case, we similarly observed that widespread distant metastasis was not evident till the patient presented with a mandibular mass as the first manifestation of distant failure.…”

Section: Discussionsupporting

confidence: 72%

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Mandibular Metastasis from a Skull Base Chordoma: Report of a Case with Review of Literature

Loehn¹,

Walvekar²,

Harton³

et al. 2009

Skull Base

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This article reports an unusual presentation wherein the first evidence of distant failure from a locally controlled, recurrent skull base chordoma was a metastasis to the mandible. We present a case report from a tertiary-care academic skull base referral center and a review of literature. A 33-year-old woman with a locally recurrent spheno-occipital chordoma that was stabilized with multimodality therapy presented with a right mandibular mass. Immunohistochemical stains demonstrated the tumor cells staining positive for vimentin, cytokeratin, epithelial membrane antigen (EMA), and S100 consistent with metastatic chordoma. Positron emission tomography-computed tomography imaging further revealed widespread distant failure. Chordomas are rare tumors with only four previous reports of metastasis to the mandible. This is the first presentation of a mandibular metastasis from a spheno-occipital chordoma. We present a review of literature and summarize the demographic, clinical, pathological, treatment-related data, and discuss followup information from previous reports of metastatic chordomas to the mandible.

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Section: Discussionsupporting

confidence: 72%

“…A review of demographics, clinical and pathological data, and follow-up information is presented in Table 1. 9,11,13,14 Our literature review did not reveal any previous reports of mandibular metastasis from a spheno-occipital chordoma. Consequently, we report possibly the first presentation of this clinical scenario.…”

Section: Discussionmentioning

confidence: 70%

Mandibular Metastasis from a Skull Base Chordoma: Report of a Case with Review of Literature

Loehn¹,

Walvekar²,

Harton³

et al. 2009

Skull Base

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“…A tumor occurring in the TMJ often obstructs the opening of the jaws; however, in the present study, the tumor in the mandibular fossa caused TMJ dislocation by pushing the condyle out of the fossa (3). The literature review revealed 11 cases of occlusal abnormality and/or TMJ dislocation due to metastasis (5 males and 6 females; age range, 49-85 years; mean age ± standard deviation, 63.7±9.6 years), 4 of which were cases of TMJ dislocation (Table I) (5,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Condylar destruction, including pathological fracture, was often observed using conventional radiography in cases of occlusal abnormality, whereas it was not observed in cases of TMJ dislocation (16)(17)(18)22).…”

Section: Discussionmentioning

confidence: 99%

Temporomandibular dislocation caused by pancreatic cancer metastasis: A case report

et al. 2017

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Abstract. Metastasis-induced dislocation of the temporomandibular joint (TMJ) is rare. The present study describes a case of TMJ dislocation caused by metastasis from pancreatic cancer, and discusses this in the context of literature on occlusal abnormality and/or dislocation due to metastasis. In the present case, unilateral TMJ dislocation was suspected when the patient first presented; destructive bone changes were not observed on conventional radiographs, and magnetic resonance imaging (MRI) revealed a tumorous lesion. The present case suggests that healthcare professionals should consider whether a malignant disease is present in cases of occlusal abnormality and/or dislocation of the TMJ, and that, in patients with TMJ dislocation that cannot easily be repositioned, additional imaging examinations, including MRI, should be performed as soon as possible, regardless of whether destructive bone changes are present. Metastasis to the TMJ is typically associated with generalized skeletal metastasis in the final stage of malignancy. Therefore, it is crucial to consider the possibility of cervical spine metastasis in order to decrease the risk of cervical fracture when attempting reduction of a TMJ dislocation, particularly in patients with a history of cancer.

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“…There have been four previous reports of chordomas metastasizing to the mandible, with three originating in the sacrococcygeal region and one originating in the lumbar spine. A review of demographics, clinical 9 Slee et al 13 Meneghini et al 11 Kulamarva et al 14 and pathological data, and follow-up information is presented in Table 1. 9,11,13,14 Our literature review did not reveal any previous reports of mandibular metastasis from a spheno-occipital chordoma.…”

Section: Discussionmentioning

confidence: 99%

Mandibular Metastasis from a Skull Base Chordoma: Report of a Case with Review of Literature

et al. 2009

View full text Add to dashboard Cite

This article reports an unusual presentation wherein the first evidence of distant failure from a locally controlled, recurrent skull base chordoma was a metastasis to the mandible. We present a case report from a tertiary-care academic skull base referral center and a review of literature. A 33-year-old woman with a locally recurrent spheno-occipital chordoma that was stabilized with multimodality therapy presented with a right mandibular mass. Immunohistochemical stains demonstrated the tumor cells staining positive for vimentin, cytokeratin, epithelial membrane antigen (EMA), and S100 consistent with metastatic chordoma. Positron emission tomography-computed tomography imaging further revealed widespread distant failure. Chordomas are rare tumors with only four previous reports of metastasis to the mandible. This is the first presentation of a mandibular metastasis from a spheno-occipital chordoma. We present a review of literature and summarize the demographic, clinical, pathological, treatment-related data, and discuss follow-up information from previous reports of metastatic chordomas to the mandible.

show abstract

Metastatic chordoma to the mandibular condyle: An anterior surgical approach

Cited by 16 publications

References 32 publications

Mandibular Metastasis from a Skull Base Chordoma: Report of a Case with Review of Literature

Mandibular Metastasis from a Skull Base Chordoma: Report of a Case with Review of Literature

Temporomandibular dislocation caused by pancreatic cancer metastasis: A case report

Mandibular Metastasis from a Skull Base Chordoma: Report of a Case with Review of Literature

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