Metastatic Crohn's Disease of the Face

Graham, Deborah B.; Jager, David; Borum, Marie

doi:10.1007/s10620-006-9533-2

Cited by 14 publications

(8 citation statements)

References 22 publications

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“…La ECM es una manifestación cutánea de la EC poco usual, en la que aparecen en la piel lesiones clínicamente inespecí-ficas en forma de placas o nódulos pigmentados, eritematosos, indurados o en ocasiones ulcerados, cuyo estudio histológico muestra granulomas no caseificantes, sin que exista contigüidad entre estas lesiones y la afectación intestinal 4,5 . Las localizaciones más frecuentes son la región genital, los pliegues cutáneos (submamario, retroauricular, inguinal y abdominales) y las extremidades inferiores, si bien las lesiones pueden aparecer en cualquier área cutánea, de forma aislada o múltiple [5][6][7][8] .…”

Section: Discussionunclassified

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Enfermedad de Crohn metastásica

Romero-Gutiérrez

Torres

Rosas

et al. 2010

Gastroenterología y Hepatología

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Section: Discussionunclassified

“…Las localizaciones más frecuentes son la región genital, los pliegues cutáneos (submamario, retroauricular, inguinal y abdominales) y las extremidades inferiores, si bien las lesiones pueden aparecer en cualquier área cutánea, de forma aislada o múltiple [5][6][7][8] .…”

Section: Discussionunclassified

Enfermedad de Crohn metastásica

Romero-Gutiérrez

Torres

Rosas

et al. 2010

Gastroenterología y Hepatología

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“…However, there is a suggestion in the limited literature available that there may be an association with perianal Crohn's disease [3]. Of the reported cases of metastatic Crohn's disease involvement primarily of the lower limbs and trunk regions with a predilection for skin fold areas and genitalia has been described [4]. There has been only one reported case of facial involvement documented more than 30 years ago.…”

Section: Discussionmentioning

confidence: 99%

“…The use of systemic and topical steroids, antibiotics, and immunosuppressive agents such as azathioprine, sulfasalazine, and methotrexate has been described with variable success [4]. The use of Infliximab, an antitumour necrosis factor monoclonal antibody, as one of the latest treatment options has been described in a few case reports to be more effective in maintaining disease remission, especially with repetitive administration and when used concomitantly with other more mainstream therapies [5–7].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Crohn's Disease of the Ear

Chuah

Kim

Allen

et al. 2009

International Journal of Otolaryngology

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Objective. We reported a very rare case of metastatic Crohn's disease involving the retro-auricular region. Method. A case report and a review of literature concerning metastatic Crohn's disease. Results. Metastatic Crohn's disease is an uncommon extraintestinal cutaneous manifestation of Crohn's disease and a very rare case involving the retro-auricular region is reported here. Given the limited existing literature little is known about this condition. The skin lesions appear to have a predilection for the lower trunk and genitalia regions. There is no clear association with the severity of Crohn's disease and in some cases, the cutaneous lesions predate the onset of gastrointestinal Crohn's disease. Treatment with immune-modulating medications together with the antitumour necrosis factor monoclonal antibody therapy appears to offer the best chance of remission. Conclusion. By reporting this interesting and rare condition we also hope to highlight the importance of considering underlying chronic systemic disorders, such as Crohn's disease, when presented with skin lesions resistant to simple local treatments.

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“…Specific oral manifestations are a result of the direct extension of intestinal inflammation of CD or the metastatic spread of CD and UC, with macroscopic changes similar to changes observed in the intestine [36–38]. Pathognomonic oral manifestations related to CD include oral granulomatosis, macrocheilia, cobblestoning of oral mucosa, mucosal tags and deep linear ulcers [39–41]. Pyostomatitis vegetans is more often seen in UC patients and reflects the active phase of the disease [42–44].…”

Section: Oral Manifestations Of Ibdsmentioning

confidence: 99%

The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review

Vasovic¹,

Gajovic²,

Brajković³

et al. 2016

cejoi

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Inflammatory bowel diseases (IBDs) are chronic, relapsing inflammatory diseases characterized by exacerbations and remissions of the gastrointestinal tract, clinically manifested as Crohn’s disease and ulcerative colitis. The etiology of IBDs is considered to be multi factorial, comprising environmental, immune, microbial and genetic factors. Clinical signs may include abdominal pain, frequent bloody diarrheas, mucorrhea, vomiting, fever, fatigue or weight loss. Changes in the oral cavity often precede intestinal symptoms. Inflammatory bowel disease leads to a significant deterioration of oral health, which indicates that cooperation between the dentist and the gastroenterologist is necessary when considering patients’ welfare. Patients with IBD have an altered immune response, but microorganisms of the oral cavity may also be responsible for its modification.This review paper discusses the correlation between the immune system and inflammatory bowel disease manifestations in the oral cavity.

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Metastatic Crohn's Disease of the Face

Cited by 14 publications

References 22 publications

Enfermedad de Crohn metastásica

Enfermedad de Crohn metastásica

Metastatic Crohn's Disease of the Ear

The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review

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