Metastatic cutaneous apocrine adenocarcinoma successfully treated with systemic anti‐androgen therapy—A case report

Collette, Fanny; Hamoir, Marc; Eeckhout, Pascal Van; Dabadie, P.; Duprez, Thierry; Schmitz, Sandra; Machiels, Jean‐Pascal

doi:10.1002/ccr3.3434

Cited by 9 publications

(3 citation statements)

References 26 publications

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“…The referral treatment is wide surgical excision with 2–3 cm margins in surrounding healthy tissue, with or without axillary lymph node dissection, which is indicated in the presence of suspicious adenopathies [ 8 , 16 ]. CACs are chemo resistant, but chemotherapy using adriablastin/cyclophosphamide or Taxanes and palliative treatment are indicated for metastatic apocrine adenocarcinoma of the axillary region [ 17 , 18 ]. Also, adjuvant radiotherapy may be used in locally or regionally advanced CAC [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous apocrine carcinoma: A challenging case report

Khessairi,

Fertani,

Sakhri

et al. 2024

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Primary cutaneous apocrine carcinoma: A challenging case report

Khessairi,

Fertani,

Sakhri

et al. 2024

International Journal of Surgery Case Reports

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“…Collette et al 33 reported the first case of PCAA treated with anti-androgen with a good response; at 19 months of treatment with 160mg of enzalutamide per day, the patient achieved a complete response confirmed by 18fluoro-2-deoxy-d-glucose-positron emission tomography-computed tomography (18FDG-PET-CT). Our patient overexpressed AR and HER-2 receptors; consequently, he was started on an androgen receptor inhibitor and HER-2 receptor blocker in addition to paclitaxel, a taxane.…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Apocrine Adenocarcinoma of the Axilla in Klinefelter’s Syndrome: A Case Report

Ilerhunmwuwa

Manvar

et al. 2023

Arch Breast Cancer

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Background: Primary Cutaneous Apocrine Adenocarcinoma (PCAA) is a rare cutaneous malignancy that arises from areas rich in apocrine glands, particularly the axilla. There are less than 200 cases described in the literature. However, none has been reported in patients with Klinefelter syndrome, who are known to have an increased risk of breast cancer, Case Presentation: We present a 66-year-old man with a significant family history of breast cancer who developed a right axillary mass initially thought to be hidradenitis suppurativa. On physical examination, he had bilateral gynecomastia. Laboratory workup was significant for hyper-gonadotrophic hypogonadism. Mammography showed bilateral gynecomastia with no radiologic evidence of malignancy in the breast, while magnetic resonance imaging of the breast revealed two suspicious masses seen in the right breast. Excision biopsy of the right axillary mass revealed a high-grade invasive adenocarcinoma involving the dermis and subcutis; the cells had prominent nucleoli vesicular chromatin pattern and voluminous eosinophilic cytoplasm consistent with primary cutaneous apocrine adenocarcinoma. Immunohistochemistry was positive for GATA-3, GCDFP-15, E-cadherin, ER Positive, PR negative, HER 2 by IHC 3 +, and androgen receptor-positive 100 %. Positron emission tomography showed mildly hypermetabolic asymmetric gynecomastia, right greater than left, but no abnormal hypermetabolic activity to suggest malignancy. Karyotype confirmed 47 XXY chromosomes which on. The patient underwent bilateral mastectomy due to his preference; excised breast tissue was negative for malignancy. Conclusion: We presented the first case report of PCAA of axillary in Klinefelter syndrome. Awareness of this association and differentiation from breast carcinoma should be undertaken.

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“…Wide excision with regional lymphadenectomy is considered to be the only curative therapy for primary cutaneous apocrine adenocarcinoma in human and veterinary medicine [ 13 , 14 ]. Radiotherapy, chemotherapy, and antiandrogen therapy have been reported as therapeutic options for primary apocrine adenocarcinoma, but there is no consensus regarding the protocol due to a lack of meta-analyses to determine treatment efficacy [ 14 , 15 , 16 ]. There are some chemotherapy protocols for adenocarcinomas of other origins [ 17 , 18 ], but these have not yet been proven in cutaneous apocrine gland ductal adenocarcinomas.…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal Metastatic Apocrine Gland Ductal Adenocarcinoma in a Beagle Dog

Moon

Min

Lee

et al. 2022

Veterinary Sciences

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Tumors of sweat glands usually originate from apocrine glands and can develop throughout the body but are rare in dogs. This report describes the retroperitoneal metastasis of primary cutaneous apocrine adenocarcinoma. An 8-year-old, spayed female beagle dog, weighing 11.7 kg, presented with a history of anorexia, hypodynamia, and weight loss. Clinical examination, radiography, ultrasonography, and computed tomography revealed a skin mass on the dorsum of the right metatarsal region, an enlarged ipsilateral popliteal lymph node, and a retroperitoneal mass. Fine-needle aspiration cytology of the popliteal lymph node suggested metastasis of an apocrine sweat gland tumor. Surgical excision of the skin mass, popliteal lymph node, and retroperitoneal mass was performed. The retroperitoneal mass was diagnosed as a metastasis of primary cutaneous apocrine adenocarcinoma. Immunohistochemistry revealed that the tumor cells were positive for cytokeratin 7 but negative for cytokeratin 20 and S100 proteins. There were no postoperative complications, except for temporary hindlimb edema, including local recurrence or metastasis, in the 6-month postoperative follow-up period. This case illustrates that although malignant apocrine gland tumors are rare in dogs, a wide resection of primary cutaneous apocrine gland adenocarcinomas is recommended because of the risk of local invasion or distant metastasis.

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Metastatic cutaneous apocrine adenocarcinoma successfully treated with systemic anti‐androgen therapy—A case report

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 9 publications

References 26 publications

Primary cutaneous apocrine carcinoma: A challenging case report

Primary cutaneous apocrine carcinoma: A challenging case report

Primary Cutaneous Apocrine Adenocarcinoma of the Axilla in Klinefelter’s Syndrome: A Case Report

Retroperitoneal Metastatic Apocrine Gland Ductal Adenocarcinoma in a Beagle Dog

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