Metastatic disease to the chest in patients with extrathoracic malignancy

Coppage, Lynn; Shaw, Coralie; Curtis, Anne McB.

doi:10.1097/00005382-198710000-00006

Cited by 80 publications

(18 citation statements)

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“…Tumour cell metastasis via the haematogenous route can result in diffuse miliary seeding [36]. UMEKI et al [34] showed that MIPC of lung cancer was associated with bone metastasis because all five of his patients had bone metastases.…”

Section: Overall Survival and Prognostic Factorsmentioning

confidence: 99%

FrequentEGFRmutations in nonsmall cell lung cancer presenting with miliary intrapulmonary carcinomatosis

Hu²,

Chang

et al. 2012

Eur Respir J

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Nonsmall cell lung cancer (NSCLC) presenting with miliary intrapulmonary carcinomatosis (MIPC) is rare. We investigated the clinical characteristics and epidermal growth factor receptor (EGFR) mutation rate of NSCLC patients with MIPC at initial diagnosis.From June 2004 to December 2008, we screened newly diagnosed NSCLC patients for MIPC using image-based criteria. We recorded clinical data and analysed EGFR mutation status. For comparison, we collected specimens from stage IV NSCLC patients without MIPC tested for EGFR mutations from April 2001 to November 2008.From 3,612 NSCLC patients, 85 patients with MIPC at initial diagnosis were identified; 81 had adenocarcinoma. Of the 85 patients, 60 had specimen sequencing to detect EGFR mutation; 42 (70%) were positive. Compared with 673 stage IV patients without MIPC, patients with MIPC had higher EGFR mutation rate (p50.036); even male smokers had a high EGFR mutation rate (91%). Multivariate analysis of prognostic factors for overall survival of the 85 patients with MIPC revealed that adenocarcinoma, absence of extrapulmonary metastasis and having EGFR mutation were associated with longer overall survival.NSCLC patients with MIPC at initial diagnosis had higher rates of adenocarcinoma and EGFR mutation. EGFR tyrosine kinase inhibition may be the treatment of choice for NSCLC patients with MIPC at initial diagnosis among Asians.

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Section: Overall Survival and Prognostic Factorsmentioning

confidence: 99%

FrequentEGFRmutations in nonsmall cell lung cancer presenting with miliary intrapulmonary carcinomatosis

Hu²,

Chang

et al. 2012

Eur Respir J

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“…Since most pulmonary metastases are in the periphery of the lung, access to these lesion is accomplished rather easily [58]. Resection of pulmonary metastases can have a favorable influence on long-term survival for certain childhood cancers such as hepatoblastoma, osteosarcoma, and soft tissue sarcomas.…”

Section: Metastatic Disease/recurrent Diseasementioning

confidence: 99%

Minimally invasive surgery for solid tumors

Holcomb

1999

Semin. Surg. Oncol.

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The use of minimally invasive surgery in patients with cancer is slowly evolving. There are a number of reports describing laparoscopy in adults for pancreatic, ovarian, gastric, and colon cancers. In addition, thoracoscopy has been described for lung and esophageal cancers. The role of laparoscopy and thoracoscopy in children with cancer is less clear because a number of pediatric neoplasms are sensitive to adjuvant therapy and surgery is often part of a planned multi‐dimensional approach. This article describes a previous reported experience with minimally invasive surgery in children with cancer, current indications for this approach, and general principles which are important regarding the operative technique. In addition, future applications for this technology are suggested. Semin. Surg. Oncol. 16:184–192, 1999. © 1999 Wiley‐Liss, Inc.

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“…Primary carcinomas such as breast, lung and stomach are the most common primary tumors reported to produce this form of dissemination (2). Lymphangitic lung metastasis from a sarcoma, presenting as a diffusely infiltrative lung disease, is rare.…”

Section: Introductionmentioning

confidence: 99%