Metastatic Disease to the Pancreas and Spleen

Showalter, Shayna L.; Hager, Eric; Yeo, Charles J.

doi:10.1053/j.seminoncol.2007.12.008

Cited by 54 publications

(50 citation statements)

References 86 publications

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“…The timing of her screening mammography suited the circumstances because her breast mass biopsies helped guide the work-up for her gastrointestinal masses. Her synchronous diagnosis of both the primary breast cancer and its metastases to both pancreas and stomach is very rare, and unfortunately also portends a poor prognosis [13–15]. The physician’s adherence to screening guidelines was the reason the primary was found when it was, and ultimately helped guide gastrointestinal work-up.…”

Section: Discussionmentioning

confidence: 99%

“…Prompt identification of the nature and origin of the lesions led to the swift initiation of appropriate systemic therapy. However, despite appropriate systemic therapy, the median survival for breast cancers presenting similarly to this patient ranged from 18 to 24 months, and only 5–10% lived more than 5 years past initial diagnosis [15]. …”

Section: Discussionmentioning

confidence: 99%

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Metastasis to the pancreas and stomach from a breast cancer primary: a case report

Kliiger¹,

Gorbaty

2017

Journal of Community Hospital Internal Medicine Perspectives

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A 60-year-old female with an unknown family history initially presented with signs and symptoms concerning for gastrointestinal cancer. Regular breast cancer screening and subsequent work-up around this time demonstrated the presence of T2N1 stage II triple positive ductal adenocarcinoma of the left breast. Follow-up imaging for her gastrointestinal symptoms demonstrated a 3.5 cm solitary mass in the pancreas and diffuse thickening of the stomach wall. Biopsies of the gastrointestinal lesions were identified as metastatic foci of the breast cancer primary. Breast cancer metastases to the stomach and to the pancreas are both very rare events. Of the breast cancer primaries that do metastasize to the gastrointestinal system, it is unusual for the primary to be ductal adenocarcinoma. The rapid succession of diagnosing the primary source of breast cancer simultaneously with its metastases is also unusual. Timely identification and appropriate management of these rare metastases was made possible due to routine breast cancer screening.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metastasis to the pancreas and stomach from a breast cancer primary: a case report

Kliiger¹,

Gorbaty

2017

Journal of Community Hospital Internal Medicine Perspectives

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“…[9] The already developed metastases are slow-growing, and if they are resectable, the 5-year survival rate is more than 50%. [3] In non-small cell lung cancer, pancreas metastasis is more commonly a part of multi-organ metastases. [5] After the diagnosis of the primary disease, metastases -including those affecting the pancreas -develop rapidly, within a few months.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] They cannot be easily diagnosed, since they are partly asymptomatic, or are associated with symptoms similar to those caused by primary pancreatic tumors. According to Hiotis' publication, 69% of patients were asymptomatic when metastases developed only within the pancreas.…”

Section: Discussionmentioning

confidence: 99%

Secondary tumors of the pancreas: four cases and literature review

Puskás

Henits

Kovács

2015

JBGC

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Four cases affected by pancreatic metastases revealed by CT and MR during the last two years are presented. In Case 1 and 2 the metastatic disease appeared more than 10 years after the primary renal neoplasm was diagnosed. In the remaining two cases -non small cell lung cancer and non-Hodgkin disease -the metastases developed shortly after the onset of the primary malignancy. A literature review is given. Metastases in the pancreas are rare. The symptoms and imaging features are variable, therefore non-invasive imaging diagnosis is difficult. To resolve this problem a thorough scrutiny of the patients' medical history, and the functional imaging methods can be helpful.

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“…Colorectal and ovarian carcinomas cause solitary splenic lesions. 10,11 Most splenic metastases are together with multivisceral metastatic disease due to hematogenous or peritoneal dissemination. 11 Our case was asymptomatic with a normal CA125 level, nevertheless recurrence was pictured by PET/CT imaging after an unusual long disease-free interval.…”

Section: Discussionmentioning

confidence: 99%