Metastatic epidural spinal column compression due to pancreatic ductal adenocarcinoma causing subacute Cauda equina syndrome: A case report

Diaz-Aguilar, Luis Daniel; Sahyouni, Ronald; Brown, Nolan J.; Olson, Scott; Osorio, Joseph A.

doi:10.25259/sni_514_2020

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…Spinal metastases originating in PC occur in both women [ 57 , 58 , 59 , 60 , 61 , 62 ] and men [ 60 ], even though a systematic review, analyzing 21 recently published studies, revealed that patients with PC and spinal metastases are predominantly males, with an average age of 59 years [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

“…Spinal locations of metastases from PC can be thoracic [ 55 ], lumbar [ 55 , 56 ], or sacral [ 62 ]. We identified only the lumbar and sacral locations.…”

Section: Discussionmentioning

confidence: 99%

“…Spinal metastases are usually reported as originating from pancreatic ductal A-CC [ 60 ], either moderately differentiated [ 63 ] or poorly differentiated [ 62 ]. The two cases in our series presented only as pancreatic ductal A-CC, poorly differentiated, thus highlighting the fact that poorly differentiated cancers are much more aggressive.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological and pathological characteristics of spinal metastases from gastrointestinal cancers – a series of 40 cases

Şelaru¹,

Sava²,

Scripcariu³

et al. 2023

Rom J Morphol Embryol

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Spinal metastases from gastrointestinal (GI) cancer are rare and as a result there are only case reports or small series in the literature. The aim of our work was to identify the demographic aspects, the location, and the histopathological aspects of spinal metastases from GI cancers diagnosed and treated in a reference Hospital in Romania over a period of nine years, and comparing the data obtained with those from the recent literature. This is a retrospective case series study on spinal metastases from GI cancers, developed in patients older than 18 years that were surgically treated between January 2013 and December 2021 within three Neurosurgery Clinics from Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania, which is a tertiary Hospital in Romania regarding the surgical treatment of spinal metastases. We included in our study the patient’s demographic data (age and gender), clinical data (location of spinal metastases), radiological investigations and pathological features of the lesions. Regarding the immunohistochemical stainings, the following antibodies were used: anti-cytokeratin (CK)7, anti-CK20, anti-CK19, anti-caudal-type homeobox 2 (CDX2), anti-human epidermal growth factor receptor 2 (HER2), and anti-Ki67. Our series included 40 adult patients (≥18 years old) with a male:female ratio of 3:1, in favor of male patients. The mean age of all patients was 66.42 years. The primary sites of spinal metastases from GI cancers were from all segments of the GI system: the most frequent, however, was from the colorectal level (40%) and the least from the oral cavity level (2.5%). The most common site of spinal metastases from GI cancer was predominantly lumbar region (47.5%), and the most frequent histological type was adenocarcinoma (57.5%), followed by hepatocellular carcinoma (27.5%), pancreatic ductal carcinoma (5%) and squamous cell carcinoma (2.5%). Our results have important clinical implications because they suggest that there are certain subsets of patients with certain types of GI cancers that cause metastases in certain regions of the spine.

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Section: Discussionmentioning

confidence: 99%

“…Spinal locations of metastases from PC can be thoracic [ 55 ], lumbar [ 55 , 56 ], or sacral [ 62 ]. We identified only the lumbar and sacral locations.…”

Section: Discussionmentioning

confidence: 99%