Metastatic glioblastoma multiforme: A rare case of long-term survival

Abstract

Glioblastoma Multiforme (GBM) is the most common primary malignant brain tumor. Median survival is usually less than 1 year from the time of diagnosis, and even in the most favorable situations, a majority of patients die within 2 years. Standard therapy consists of surgical resection, radiotherapy and chemotherapy. In this case report, we described a 38 y old woman with GBM survived 7 years after a series of treatments. For the patient, the tumor was found extensively infiltrate the sagittal sinus, the surgery unable completely remove of tumor, radiotherapy, chemotherapy and individualized anti-cancer herbs therapy were further applied. After all therapy, the patient was awake, with moderate bone window tension, palpable mass, right partial hemianopia, good right limb muscle strength. In summary, comprehensive treatment schedule including thorough surgical removal of tumor, systematic radiation, standard chemotherapy and individualized anti-cancer herbs therapy can help to prolong the survival of patients with GBM and gliosarcoma.

Glioblastoma multiforme con metástasis a cuello

“…El GBM es uno de los tumores más complicados de tratar en neurocirugía, su mortalidad es elevada y gran parte de los pacientes fallecen por metástasis, hipertensión intracraneal u otras complicaciones, su mediana de supervivencia es de aproximadamente seis meses o un año 9 . La existencia de células madre tumorales puede tener implicaciones terapéuticas, ya que las terapias que no eliminan estas células serán ineficaces para erradicar el tumor, su manejo en la actualidad incluye cirugía, quimioterapia y radioterapia, pero la supervivencia es significativamente baja en pacientes jóvenes, por lo que el tratamiento adecuado en términos de eficacia y seguridad es un tema de debate 10 .…”

Postoperative Extra-Cranial Metastasis of Glioblastoma: A Case Report

“…The tumor mortality is high and most patients die due to oncothlipsis, intracranial hypertension or other complications. The median survival is about one year (7). Blood brain barrier, lack of true lymphatic system and low survival rate are considered as some reasons to explain why distant metastasis of this tumor is very rare (8).…”

“…The tumor mortality is high and most patients die due to oncothlipsis, intracranial hypertension or other complications. The median survival is about one year ( 7 ).…”