Metastatic Hepatocellular Carcinoma to Parotid Glands

Abstract

Patient: Male, 66Final Diagnosis: Hepatocellular carcinomaSymptoms: Abdominal distension • painful right facial swelling • weight lossMedication: —Clinical Procedure: —Specialty: —Objective:Rare diseaseBackground:Hepatocellular carcinoma is a common cancer, but it rarely metastasizes to the salivary glands. A review of the literature revealed only 5 reported cases of hepatocellular carcinoma metastatic to parotid glands. We here report an additional case of this rare association.Case Report:A 66-year-old male with a background of type 2 diabetes mellitus and post-alcoholic decompensated liver cirrhosis presented with a progressively enlarging painful right facial swelling for 2 months that was eventually found to be due to hepatocellular carcinoma metastatic to the right parotid gland. Fine needle aspiration from the right parotid showed sheets and single malignant cells that were interpreted as carcinoma not otherwise specific. However, biopsy showed metastatic hepatocellular carcinoma into the right parotid gland.Conclusions:We report an additional case of the rare metastasis of hepatocellular carcinoma to the parotid glands. It should therefore be considered in a patient with decompensated liver cirrhosis presenting with a parotid swelling. Furthermore, the present case demonstrates the importance of the tissue biopsy for obtaining an accurate final diagnosis.

NKAP plays an oncogenic function partly through AKT signaling pathway in hepatocellular carcinoma

“…Previous studies have revealed many factors contributing to HCC pathogenesis, such as hepatitis B/C virus infection, alcohol abuse, liver cirrhosis, gene mutation, and so on [3]. Despite great advances in HCC treatment strategies such as sorafenib, liver transplantation and percutaneous ablation, the survival rate of HCC patients remains very poor, 3-5% within 5 years [3][4][5][6][7]. With the development of bioinformatics, gene expression profile of HCC has been fully characterized and many of the genetic abnormalities contributing to HCC, such as potential oncogenes and tumor suppressor genes, are well known [8][9][10].…”

miR-630 Overexpression in Hepatocellular Carcinoma Tissues is Positively Correlated with alpha-Fetoprotein

“…The prognosis of HCC is poor and most patients are generally diagnosed at advanced stage [2,3]. Approximately 600,000 HCC patients die annually, making it the fifth most common cause of cancer-related death worldwide [4].…”

“…Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, with very high morbidity and mortality [ 1 ]. The prognosis of HCC is poor and most patients are generally diagnosed at advanced stage [ 2 , 3 ]. Approximately 600,000 HCC patients die annually, making it the fifth most common cause of cancer-related death worldwide [ 4 ].…”