Metastatic Hypernephroma to the Head and Neck: Unusual Case Reports and Review of the Literature

Sabo, Reni; Sela, M.; G, Sabo; Herskovitz, Pearl; Feinmesser, Raphael

doi:10.2310/7070.2001.19965

Cited by 16 publications

(4 citation statements)

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“…[1][2][3][4][5] In our study, almost onehalf of MEC contained a variable clear cell component ranging from 20-60% of the tumor, which may pose a challenge in the distinction from the common metastatic CCRCC in the head and neck. [12][13][14][15][16][17][18] Two relative sensitive and specific RCC makers, RCCma and PAX2, have become widely used for aid of diagnosis of both primary and metastatic RCC. [6][7][8][9][10] RCCma antigen is a 200-kd glycoprotein expressed in normal human renal proximal brush border.…”

Section: Discussionmentioning

confidence: 99%

Expression of PAX2 and Renal Cell Carcinoma Antigen in Mucoepidermoid Carcinoma

Liu¹,

Cheney²,

Omilian³

et al. 2012

N A J Med Sci

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Clear cell renal cell carcinoma (CCRCC) is the most common metastatic clear cell tumor in the head and neck. The most common primary tumor of the head and neck with clear cell morphology is mucoepidermoid carcinoma (MEC). The distinction between MEC with clear cells (CMEC) and metastatic CCRCC can be challenging in a small biopsy specimen. Expression of PAX2 and renal cell carcinoma antigen (RCCma) has been widely used to aid of diagnosis for both primary and metastatic RCC. The aim of this study is to evaluate the utility of expression of PAX2 and RCCma between CMEC and metastatic CCRCC in a clinical setting using tissue microarrays (TMAs). In primary CCRCC, the nuclear immunoreactivity for PAX2 was found in 47 of 120 cases (39%), and the membranous staining pattern for RCCma was revealed in 69 of 120 cases (58%). The immunostain profiles of metastatic RCC showed positive staining for PAX2 in 21 of 94 cases (22%) and RCCma in 19 cases (20%), respectively. Two of six cases (33%) of metastatic RCC to the head and neck region display immunoreactivity for either PAX2 or RCCma. For MEC, positive membranous and cytoplasmic staining of RCCma was found in 3 of 23 cases (13%), and diffuse cytoplasmic reactivity for PAX2 was noted in 19 cases (83%). However, none of MEC showed nuclear reactivity that is specific for PAX2. Results of our study suggest that although PAX2 and RCCma are relatively specific for CCRCC, one should be cautious when interpreting the results of RCCma and PAX2 expression in the setting of CMEC versus metastatic CCRCC, particularly in a biopsy specimen. Clinicopathologic correlation combined with histomorphology and a panel of immunohistochemical markers is essential to render correct diagnosis.

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Section: Discussionmentioning

confidence: 99%

Expression of PAX2 and Renal Cell Carcinoma Antigen in Mucoepidermoid Carcinoma

Liu¹,

Cheney²,

Omilian³

et al. 2012

N A J Med Sci

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“…Metastatic CCRCC to the head and neck is uncommon and can affect parotid and submandibular glands, 12-14 mandible, 7,12 maxilla and paranasal sinuses, 12,15 nasopharynx/palate, 12 nasal cavity, 15,16 ethmoid sinus/orbital region, 17 and thyroid. 12,18 Intraoral soft tissue metastases from CCRCC are very rare, affecting the tongue, 6,15-17,19-23 palate, 5,15,24 buccal mucosa/upper lip, 25 gingiva, 26,27 lower lip, 15 and floor of mouth. 4 Clinically, oral metastatic CCRCC can show typical features of aggressive malignant lesions, such as an ulcerated hemorrhagic symptomatic swelling, or it can appear as an asymptomatic submucosal nodule.…”

Section: Discussionmentioning

confidence: 99%

Metastatic renal cell carcinoma to the oral cavity and clear cell mucoepidermoid carcinoma: comparative clinicopathologic and immunohistochemical study

Pires

Azevedo

Ficarra

et al. 2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…5-7 Renal cell carcinoma is associated with an 8% to 15% incidence of metastatic disease to the head and neck, most commonly to lymph nodes, nasal cavities, and paranasal sinuses, although metastatic RCC has been reported in the temporal bone and confused for JP. 5,7-9 Radiographically, metastatic RCC may appear similar to JP with a slow-growing pattern of permeative bony destruction on CT, highly vascular with avid contrast enhancement, and similar “salt-and-pepper” appearance as JP on MRI. 4,5,7…”

Section: Introductionmentioning

confidence: 99%