Metastatic Invasive Breast Cancer Recurrence Following Curative-Intent Therapy for Ductal Carcinoma In Situ

Mushawah, Fatema Al; Rastelli, Antonella; Pluard, Timothy; Margenthaler, Julie A.

doi:10.1016/j.jss.2011.04.058

Cited by 6 publications

(2 citation statements)

References 47 publications

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“…LR after mastectomy for DCIS in most series is between 1–3% [56–59]. Similarly, Slavin et al [11] had no recurrences over 45 months for 26 cases of SSM for DCIS.…”

Section: The Skin-sparing Mastectomymentioning

confidence: 99%

Oncologic Safety of Skin-Sparing and Nipple-Sparing Mastectomy: A Discussion and Review of the Literature

Tokin

Weiss

Wang‐Rodriguez

et al. 2012

International Journal of Surgical Oncology

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Breast conservation therapy has been the cornerstone of the surgical treatment of breast cancer for the last 20 years; however, recently, the use of mastectomy has been increasing. Mastectomy is one of the most frequently performed breast operations, and with novel surgical techniques, preservation of the skin envelope and/or the nipple-areolar complex is commonly performed. The goal of this paper is to review the literature on skin-sparing mastectomy and nipple-sparing mastectomy and to evaluate the oncologic safety of these techniques. In addition, this paper will discuss the oncologic importance of margin status and type of mastectomy as it pertains to risk of local recurrence and relative need for adjuvant therapy.

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“…LR after mastectomy for DCIS in most series is between 1–3% [56–59]. Similarly, Slavin et al [11] had no recurrences over 45 months for 26 cases of SSM for DCIS.…”

Section: The Skin-sparing Mastectomymentioning

confidence: 99%

Oncologic Safety of Skin-Sparing and Nipple-Sparing Mastectomy: A Discussion and Review of the Literature

Tokin

Weiss

Wang‐Rodriguez

et al. 2012

International Journal of Surgical Oncology

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“…Among prognostic factors for the outcome in DCISM, the number of microinvasive foci, metastases to the sentinel lymph node, high Ki-67, negative oestrogen receptor status, and HER2 overexpression were found [3,9]. The number of microinvasive foci is probably higher in more extensive DCIS.…”

Section: Case Presentationmentioning

confidence: 99%

Human epidermal growth factor receptor 2-positive microinvasive breast carcinoma with a highly aggressive course: a case report

Kuhar

Matos

2014

BMC Res Notes

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BackgroundMicroinvasive ductal carcinoma in situ of the breast is a rare entity defined as ductal carcinoma in situ with invasive foci measuring no more than 1 mm. In general, the outcome is excellent, similar to ductal carcinoma in situ. We report a patient with breast ductal carcinoma in situ with microinvasion who died eight months after diagnosis due to progression of the disease – liver metastases. This is the first report in the literature of such an aggressive course.Case presentationA 47-year-old Caucasian woman presented with mammographic-detected suspicious microcalcinations in an area of 8.6 x 6 cm. A radical mastectomy with a sentinel lymph node biopsy and immediate breast reconstruction with implant was performed. A histopathological report showed a massive high grade ductal carcinoma in situ, of the solid and comedo type. In one quadrant, some foci of microinvasions of less than 1 mm were present. Tumour margins were free. Isolated tumour cells were found in the sentinel lymph node. Hormone receptors were negative and human epidermal growth factor receptor-2 status was not performed. The patient received no adjuvant systemic therapy. Eight months after the surgery, she died from hepatic failure without known breast cancer progression before. An autopsy revealed diffuse liver metastases with human epidermal growth factor receptor 2-positive, hormone receptor negative breast cancer. Dissemination to other organs was not proven.ConclusionOur patient is a rare case of ductal carcinoma in situ with microinvasion that developed distant metastases very early. In case of multiple foci of microinvasion, besides radical local treatment we suggest considering adjuvant systemic treatment based on biological characteristics since tumour size alone does not predict the prognosis well.

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The locoregional recurrence post-mastectomy for ductal carcinoma in situ: Incidence and risk factors

et al. 2015

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Metastatic Invasive Breast Cancer Recurrence Following Curative-Intent Therapy for Ductal Carcinoma In Situ

Cited by 6 publications

References 47 publications

Oncologic Safety of Skin-Sparing and Nipple-Sparing Mastectomy: A Discussion and Review of the Literature

Oncologic Safety of Skin-Sparing and Nipple-Sparing Mastectomy: A Discussion and Review of the Literature

Human epidermal growth factor receptor 2-positive microinvasive breast carcinoma with a highly aggressive course: a case report

The locoregional recurrence post-mastectomy for ductal carcinoma in situ: Incidence and risk factors

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