Metastatic involvement of four eyelids

Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal

“…Cutaneous metastases may be the first indication of an internal malignancy 1 but more often are a late manifestation of widely disseminated disease and portend a very poor prognosis 2 . Sites such as the scalp, 1,3 , 4 umbilicus, 5,6 chest wall, 7 and abdominal wall 7 are commonly involved, although metastatic lesions may occur at almost any location, and have been reported in such diverse sites as the nail bed, 8,9 scrotum, 10 and ear 11–16 . Metastatic lesions typically present as painless nodules, 3,17 , 18 but may mimic benign entities as well.…”

“…lesions may occur at almost any location, and have been reported in such diverse sites as the nail bed, 8,9 scrotum, 10 and ear. [11][12][13][14][15][16] Metastatic lesions typically present as painless nodules, 3,17,18 but may mimic benign entities as well. The distribution of cutaneous metastasis roughly corresponds to the overall incidence of the various visceral malignancies, with carcinomas of the lung, colon, and breast leading.…”