Metastatic lesions: A diagnostic dilemma-retrospective study, Srinagar, Jammu and Kashmir, India

Abstract

Background:Renal clear cell carcinoma (RCC) accounts for about 3% of adult malignancies and about 90% of neoplasms of the kidney. It is most common in men aged 50 to 60 years old. RCC has different manifestations, including metastasis in uncommon sites and paraneoplastic syndromes.Aims:To evaluate the clinicopathological pattern of RCC.Materials and Methods:This study was conducted in the Department of Pathology, Government Medical College, Srinagar. It was a retrospective study done over a period of 5 years, November 2009 to November 2014.Results:The study was done to evaluate the clinicopathological pattern of 6 cases of RCC diagnosed at a tertiary care hospital. All patients were males, presenting with submandibular swellings without any other symptom. Radiological and histopathological examination proved the lesion as metastasis of renal cell carcinoma to the mandible.Conclusion:Being a rare presentation in the head and neck region, metastatic renal cell carcinoma needs to be considered in the differential diagnosis of submandibular swellings even in patients younger than 40 years.

An Older Woman Presenting with Jaw Pain and a Kidney Mass

“…RCC is the most common solid tumor of the kidney, representing 90% of primary kidney tumors. The classic presenting symptoms are the triad of hematuria, flank pain, and a palpable abdominal mass (Grawitz triad) 1 ; however, this presentation only occurs in 10%–15% of patients with RCC. 2 This disease often presents at advanced stages with metastases 3 to the lung, bone, lymph nodes, adrenal glands, and brain.…”

“… 2 RCC commonly spreads to orofacial soft tissues and sinuses; however, only 1% of patients with RCC demonstrate isolated head and neck metastases. 1 Breast, liver, and thyroid cancers are the most common cause of oral metastases in women. 4 Mandibular lesions that presented in this case would more commonly raise suspicion for a primary head and neck cancer, such as squamous cell carcinoma, parotitis, or Warthin tumor.…”