Metastatic Liposarcoma to the Parotid

Trabelsi, Amel; Abdelkrim, Soumaya Ben; Jemni, H.; Stita, Wided; Ouni, Chadia; Dhouibi, Abdelmejid; Hmissa, Sihem; Mokni, Moncef; Korbi, S.

doi:10.1155/2008/715153

Cited by 9 publications

(12 citation statements)

References 3 publications

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“…However, the parotid gland was the third most common site for liposarcoma of the oral and salivary gland region in the AFIP series of 18 patients reported by Fanburg-Smith et al [45] Histological subtypes of the four patients included in this latter study were well differentiated/lipoma-like (2), myxoid (1) and dedifferentiated (1) liposarcoma [45]. Rare cases of liposarcoma metastatic to the parotid gland have been reported and should be included in the differential diagnosis of liposarcoma at this unusual location [46]. Bilateral atypical lipomatous tumors of the neck may coexist with bilateral lipomatous changes of the parotid in patients with Madelung disease [21].…”

Section: Rare Lipoma Variantsmentioning

confidence: 73%

Fat-Containing Salivary Gland Tumors: A Review

Agaimy

2013

Head and Neck Pathol

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Fat-containing tumors of the salivary glands are uncommon. Their wide histological spectrum varies from pure lipomatous neoplasms similar to their cutaneous and soft tissue counterparts to mixed lipoepithelial lesions specific to the salivary glands. With few exceptions, these uncommon lesions affect mainly the elderly, with a mean age at presentation of C50 years and show a predilection for males. A few cases occur in childhood; some of them represent congenital lesions. In decreasing order of frequency, ordinary (soft-tissue type) lipoma, oncocytic lipoadenoma, non-oncocytic sialolipoma, and pleomorphic adenoma/myoepithelioma with extensive lipometaplasia are the main variants of fat containing tumors encountered in the salivary glands. While pleomorphic adenoma/myoepithelioma with lipometaplasia behave in the same way as their non-fat-containing counterparts, other lipomatous salivary gland tumors listed above are cured with simple excision and do not carry a risk of recurrence. Other lipoma variants (spindle cell lipoma, osteolipoma, fibrolipoma, angiolipoma, pleomorphic lipoma, lipoblastoma and hibernoma) are exceptionally rare in the salivary gland. Atypical lipomatous tumors/liposarcoma have been only rarely reported in the salivary gland and they behave in a similar fashion to their soft-tissue counterparts. Diffuse lipomatosis and lobular fatty atrophy are the two tumor-like lesions that might closely mimic sialolipoma, particularly in limited biopsy material without knowledge of the gross findings. This review summarizes the clinicopathological features of the main types of salivary fat-containing lesions and discusses their differential diagnoses.

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Section: Rare Lipoma Variantsmentioning

confidence: 73%

Fat-Containing Salivary Gland Tumors: A Review

Agaimy

2013

Head and Neck Pathol

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“…Amel Trabelsi et al 13 and Alemán López et al 14 reported two similar cases of liposcarcomas metastatic to the parotid gland in two patients with a history of resected lower limb liposarcoma. Our case represents the third case reported in the literature of a lower extremity myxoid liposarcoma metastatic to the parotid gland.…”

Section: 3mentioning

confidence: 98%

“…Management is typically surgical excision, with or without radiotherapy. [2][3][4]13 However, these seem to be palliative measures since the prognosis is poor, and the patient is likely to die from their disease. Immunohistochemical staining with S100, which shows diffuse staining in the majority of myxoid liposarcomas, 2 was negative in our case; therefore, molecular testing played a key role in confirming the diagnosis.…”

Section: 3mentioning

confidence: 99%

Myxoid liposarcoma: A case report of a sentinel metastasis to the parotid gland with molecular confirmation

Been

Olar

Powers

et al. 2010

Diagnostic Cytopathology

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Myxoid liposarcoma is a subtype of liposarcoma with a predilection for the deep soft tissues of the extremities that accounts approximately for 10% of all adult soft tissue sarcomas. We report a case of a metastatic myxoid liposarcoma to the parotid gland, with fine-needle aspiration cytology correlation and molecular characterization. The lesion was diagnosed in a 53-year-old Hispanic male who presented with a left posterior thigh mass. A core needle biopsy established the diagnosis of myxoid liposarcoma. The patient underwent limb-sparing, wide local excision of the malignancy and later presented with an initial metastatic lesion to the parotid gland. The diagnosis of metastatic myxoid liposarcoma was rendered by fine-needle aspiration cytology with cell block preparation, and molecular confirmation. Although myxoid/round cell liposarcomas are classically described as having minimal pleomorphism on cytologic material, we encountered significant pleomorphism in our case. Therefore, a diagnosis of myxoid/round cell liposarcoma should still be a diagnostic consideration even if markedly pleomorphic cells are seen in fine-needle aspiration biopsies.

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“…Among the histologic subtypes most commonly encountered are renal cell carcinoma 6 , breast cancer 7 , lung cancer 8 , and prostate cancer 9 . Rarely reported entities include adrenal neuroblastoma, rhabdomyosarcoma, leiomyosarcoma, hepatocellular carcinoma, liposarcoma, and urachus adenocarcinoma of the urinary bladder [10][11][12][13] .Immunohistochemistry has improved the differential diagnosis of such lesions. Germ cell tumours in the testis usually metastasize to retroperitoneal lymph nodes, lungs, liver, and brain.…”

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confidence: 99%

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Isolated Late Metastasis from Testicular Seminoma Presenting as a Parotid Gland Mass: Case Report and Review of the Literature

2013

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metastasize to the parotid lymph nodes 2 . Extremely rare neoplasms in the head-and-neck region that have been reported to metastasize to the parotid gland include malignant hemangiopericytoma, atypical fibroxanthoma, Merkel cell carcinoma, epithelioid hemangioendothelioma, and chondrosarcoma [3][4][5] .Parotid gland metastases from carcinomas in sites not in the head and neck are rare. Among the histologic subtypes most commonly encountered are renal cell carcinoma 6 , breast cancer 7 , lung cancer 8 , and prostate cancer 9 . Rarely reported entities include adrenal neuroblastoma, rhabdomyosarcoma, leiomyosarcoma, hepatocellular carcinoma, liposarcoma, and urachus adenocarcinoma of the urinary bladder [10][11][12][13] .Immunohistochemistry has improved the differential diagnosis of such lesions. Germ cell tumours in the testis usually metastasize to retroperitoneal lymph nodes, lungs, liver, and brain. Other lymphatic or organ metastases are rare, especially in the headand-neck area. Nonetheless, a few cases of germ-cell neoplasia metastatic to cervical lymph nodes have been reported in the English-language literature; some of these represented the first manifestation of the primary tumour [14][15][16][17] .Qiu et al. 18 reported the first and only case to date of seminoma metastatic to the parotid gland. Here, we present a similar rare case of a singular late metastasis from a testicular seminoma, presenting as an extensive parotid gland mass 5 years after completion of primary polychemotherapy. CASE DESCRIPTIONA 45-year-old man presented in January 2012 with a large progressive and painless space-occupying lesion that had been present for 6 months in the area of the right mandibular angle. Ultrasonography showed a hypoechoic, inhomogeneous, diffusely perfused intraparotid lesion, 6×4 cm in size [ Figure 1(A,B)]. Computed tomography of the neck, chest, and abdomen with contrast enhancement showed a space-occupying lesion 8.0×7.7 cm in ABSTRACTParotid metastases from non-head-and-neck cancers are rare and may represent a diagnostic and therapeutic challenge. A late metastasis to the parotid gland from a seminoma is an unusual manifestation of disease. A 45-year-old man with a history of testicular seminoma 5 years earlier presented with a rapidly progressing parotid mass. Ultrasonography and computed tomography showed a space-occupying lesion at the angle of the right jaw. The mass was infiltrating into the parotid gland and into the parapharyngeal space. A primary parotid neoplasm was suspected, and panendoscopy combined with open biopsy was performed. Histology examination confirmed a seminoma metastatic to the parotid gland, and comparison with the primary tumour showed identical histology. The patient received chemotherapy for recurrent seminoma in accordance with the pei (cisplatin, etoposide, ifosfamide) protocol. After 4 courses of chemotherapy, salvage radical parotidectomy with removal of all suspicious residual tumour tissue was performed.This case illustrates the difficulties that may be encountered ...

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Metastatic Liposarcoma to the Parotid

Cited by 9 publications

References 3 publications

Fat-Containing Salivary Gland Tumors: A Review

Fat-Containing Salivary Gland Tumors: A Review

Myxoid liposarcoma: A case report of a sentinel metastasis to the parotid gland with molecular confirmation

Isolated Late Metastasis from Testicular Seminoma Presenting as a Parotid Gland Mass: Case Report and Review of the Literature

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