Metastatic Lung Adenocarcinoma to the Iris Mimicking Cogan-Reese Syndrome

Harvey, Ben J.; Grossniklaus, Hans E.; Traynor, Matthew P.; Sarkisian, Steven R.; Stone, Donald U.

doi:10.1097/ijg.0b013e3182208a2e

Cited by 5 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most commonly, in 65% of eyes, radiotherapy was used. [12][13][14] A high index of suspicion is warranted for unilateral nonresolving anterior uveitis or glaucoma because there could be an underlying malignancy. When considering the overall poor prognosis of these patients with median time to death of 10 months, plaque radiotherapy occupies only 1% of their remaining days compared with EBRT at 7%.…”

Section: Shields Et Almentioning

confidence: 99%

Iris Metastasis From Systemic Cancer in 104 Patients

Shields

Kaliki

Crabtree

et al. 2015

Cornea

View full text Add to dashboard Cite

show abstract

Section: Shields Et Almentioning

confidence: 99%

Iris Metastasis From Systemic Cancer in 104 Patients

Shields

Kaliki

Crabtree

et al. 2015

Cornea

View full text Add to dashboard Cite

show abstract

Ocular Tumors and Glaucoma

Tong

Ozment

Chen

2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

View full text Add to dashboard Cite

Asymptomatic iris metastasis of small-cell lung cancer

et al. 2012

View full text Add to dashboard Cite

A 70-year-old man was diagnosed with smallcell lung cancer (SCLC) of the left upper lobe, with a TNM classification of cT4N3M1b (PUL, OSS, BRA, HEP). A single asymptomatic brain metastasis 1 cm in diameter was also identified. The patient underwent four cycles of cisplatin plus irinotecan therapy, with a total effect of partial response. Complete remission of the brain metastasis was also achieved, and whole-brain radiation therapy (WBRT) was postponed at the request of the patient. Six months after diagnosis, he was admitted to our hospital with a major complaint of dizziness. Computed tomography showed enlargement of the primary lesion and multiple brain metastases. WBRT was started, but performance status did not improve. While undergoing WBRT, the patient complained of blurred vision. The ophthalmologist found a metastasis on the right iris by chance, although blurred vision was caused by detachment of the left retina. Two months later, the patient died of respiratory failure. Autopsy histologically confirmed the iris metastasis of SCLC. Cases of iris metastasis diagnosed before death are rarely reported. Iris metastases are estimated to account for 9 % of uveal metastases. This may suggest that many iris metastases have few clinical signs and are difficult to diagnose. Asymptomatic iris metastases, particularly among patients with SCLC, are thus likely to be underdiagnosed. Ocular metastasis should be considered when a cancer patient complains of visual disturbance.

show abstract

Metastatic Lung Adenocarcinoma to the Iris Mimicking Cogan-Reese Syndrome

Abstract: Iris metastases have varied presentations, and one must consider metastatic disease in any patient with a history of cancer presenting with iris lesions. The formation of an iris membrane and nodules by metastatic adenocarcinoma to the iris may mimic Cogan-Reese syndrome.

Cited by 5 publications

References 14 publications

Iris Metastasis From Systemic Cancer in 104 Patients

Iris Metastasis From Systemic Cancer in 104 Patients

Ocular Tumors and Glaucoma

Asymptomatic iris metastasis of small-cell lung cancer

Contact Info

Product

Resources

About