Metastatic malignant melanoma manifesting as an intracardiac mass

Wood, A. J.; Markovic, Svetomir N.; Best, Patricia J.M.; Erickson, Lori A.

doi:10.1016/j.carpath.2008.12.010

Cited by 17 publications

(24 citation statements)

References 24 publications

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“…Tumor cell deposition within the heart could either occur along the endocardium, preferably in the right atrium and right ventricle, due to metastatic seeding in venous blood draining from parts of the body involved in malignant melanoma. In accordance with published data, this preferably affects the right ventricle and especially the right atrium (6, 17), possibly due to filtration of the blood in the pulmonary capillary vessels reducing the probability of endocardial deposition in the left ventricle [25]. On the other hand, left atrial metastases are more commonly seen in patients with pulmonary metastases whose tumor cells are thought to embolize through the venous circulation of the lung [19].…”

Section: Discussionsupporting

confidence: 72%

Imaging characteristics of cardiac metastases in patients with malignant melanoma

et al. 2017

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BackgroundDue to prolonged survival and technical advances in CT imaging, cardiac metastases in patients with malignant melanoma are observed more frequently nowadays. The aim of the present study was to assess the anatomic distribution as well as the morphologic and histologic appearance of cardiac metastases from malignant melanoma.MethodsTwenty five patients with known metastasized melanoma and with incidental finding of cardiac metastases during routine staging CT were retrospectively included in this study. CT images were assessed for the presence, localization and extent of cardiac metastases. Histological results, mutational analysis and tumor markers were reviewed.ResultsFourteen out of 25 patients presented with singular cardiac mass (56%), whereas ten patients (40%) presented with multifocal and one patient with disseminated cardiac metastases. Twelve patients presented with endocardial (48%), eight with myocardial and two with pericardial metastases. Most frequent site involved in endocardial metastases was the right atrium (67%) followed by the right ventricle (33%). There seems to be a correlation between histological subtype and location of cardiac metastasis. Median survival after diagnosis of cardiac metastases was 8 months, with no significant difference regarding the localization of metastases within the heart.ConclusionCardiac metastases can involve every part of the heart possibly in dependence of histological subtype. The awareness of different types of cardiac metastases and their characteristic appearance on CT images is necessary for further investigations and might contribute to targeted therapy.

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Section: Discussionsupporting

confidence: 72%

Imaging characteristics of cardiac metastases in patients with malignant melanoma

et al. 2017

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“…Intercardiac metastasis of melanoma, melanoma variants and soft tissue sarcomas are more common than many clinicians realize and noted to be a fairly common autopsy finding in patients with metastatic melanoma [1]. Our case presented is one of extensive cardiac tumor involvement, which was not fully appreciated by transthoracic echocardiography (TTE) and was found to be quite extensive when a transesophageal echocardiography (TEE) was performed.…”

Section: Introductionmentioning

confidence: 80%

“…Relative to the heart, one author indicated cardiac metastasis was observed upon autopsy in 45 out of 70 patients with malignant melanoma. Malignant melanoma most commonly involves the myocardium and a preference for the right atrium, although any location could potentially be involved [1]. One theory for melanomic cardiac affinity relates to a common embryonic neural crest origin [3].…”

Section: Discussionmentioning

confidence: 99%

A Large Intracardiac Clear Cell Sarcoma Metastasis

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2018

JAICM

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“…The most common sites are the epicardium, right atrium, and left ventricle. 6 Direct invasion of a tumor to the heart typically occurs with bronchial, breast, and esophageal malignancies due to their close proximity to the heart. Direct transvenous extension can occur with primary lung carcinoma, thymic tumors, renal cell carcinoma, hepatocellular carcinoma, neuroblastoma, Wilms’ tumor, leiomyosarcoma, and adrenal adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%