Metastatic malignant melanoma of unknown primary in temporalis muscle

Grech, Alexia; Mercieca, N.; Calleja‐Agius, Jean; Abela, Rachel

doi:10.1093/jscr/rjaa202

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…The paravertebral and proximal limb muscles are most affected [4]. Some cases were initially misdiagnosed as a lipoma [9]. However, the diagnosis of certainty is anatomopathological from a muscle or lymph node biopsy.…”

Section: Discussionmentioning

confidence: 99%

Melanoma of unknown primary with skeletal muscle metastasis. A case report

Andrianandrasana

Randrianarisoa

Navoly

et al. 2022

Preprint

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Background: Melanoma is usually discovered from an irregular skin patch or a modification of a pre-existing patch. Cutaneous and lymph node metastases are common. Muscle metastasis are rare. We report a case of melanoma with infiltration of the gluteus maximus, which had normal dermatological examination.Case presentation: A 43-year-old man with no history of skin surgery was admitted with progressively worsening dyspnea. On admission, he presented with superior vena cava syndrome, painless cervical lymphadenopathy and a painful swelling in the right buttock. Skin and mucous membrane examination did not reveal any abnormal or suspicious lesions. The biology was limited to a C-reactive protein of 40 mg/L, a white blood cell count of 23 G/L and a lactate dehydrogenase level of 1705 U/L. The computed tomography scan showed several lymphadenopathies, compression of the superior vena cava and a tissue mass at the expense of the gluteus maximus. Cervical lymph node biopsy and cytopuncture of the gluteus maximus were consistent with a secondary melanoma location. A stage III melanoma of unknown primary origin associated with lymph node metastases and extension to the right gluteus maximus was suggested.Conclusions: Melanoma of unknown primary accounts for 3% of diagnosed melanomas. Diagnosis is difficult in the absence of a skin lesion. Patients are diagnosed with multiple metastases. Muscle involvement is unusual and may suggest a benign pathology. In this context, biopsy remains essential for diagnosis.

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Section: Discussionmentioning

confidence: 99%

Melanoma of unknown primary with skeletal muscle metastasis. A case report

Andrianandrasana

Randrianarisoa

Navoly

et al. 2022

Preprint

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Melanoma of unknown primary origin with skeletal muscle metastasis: a case report

Andrianandrasana

Randrianarisoa²,

Navoly

et al. 2023

J Med Case Reports

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Background Melanoma is usually discovered from an irregular skin patch or a modification of a preexisting patch. Cutaneous and lymph node metastases are common. Muscle metastases are rare. We report a case of melanoma with infiltration of the gluteus maximus, which had normal dermatological examination. Case presentation A 43-year-old Malagasy man with no history of skin surgery was admitted with progressively worsening dyspnea. On admission, he presented with superior vena cava syndrome, painless cervical lymphadenopathy, and a painful swelling in the right buttock. Skin and mucous membrane examination did not reveal any abnormal or suspicious lesions. The biology was limited to a C-reactive protein of 40 mg/L, a white blood cell count of 23 G/L, and a lactate dehydrogenase level of 1705 U/L. The computed tomography scan showed several lymphadenopathies, compression of the superior vena cava, and a tissue mass at the expense of the gluteus maximus. Cervical lymph node biopsy and cytopuncture of the gluteus maximus were consistent with a secondary melanoma location. A stage IV melanoma of unknown primary origin, and with stage TxN3M1c associated with lymph node metastases and extension to the right gluteus maximus, was suggested. Conclusions Melanoma of unknown primary origin accounts for 3% of diagnosed melanomas. Diagnosis is difficult in the absence of a skin lesion. Patients are diagnosed with multiple metastases. Muscle involvement is unusual and may suggest a benign pathology. In this context, biopsy remains essential for diagnosis.

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Comprehensive Literature Review on Melanoma of Unknown Primary Site Triggered by an Intriguing Case Report

Bordeanu-Diaconescu,

Cretu,

Grosu-Bularda

et al. 2024

Diagnostics

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Melanoma is one of the most aggressive forms of skin cancer. While most melanomas have a discernible primary site, a small subset, approximately 3.2%, present as a metastatic disease without an identifiable primary origin, a condition known as melanoma of unknown primary (MUP). Unusual cases of primary melanoma have also been previously reported in the respiratory, gastrointestinal, and urogenital tracts. MUP typically is found in lymph nodes, subcutaneous sites, and visceral organs, with hypotheses about its origin including spontaneous primary tumor regression and ectopic melanocytes. MUP presents unique challenges in diagnosis and treatment due to the absence of a detectable primary tumor. Understanding its genetic and molecular features, epidemiology, prognostic factors, and treatment options is crucial for optimizing patient care and outcomes in this subset of melanoma patients. We conducted an extensive literature review triggered by a case report of a patient with suspected MUP. A 51-year-old woman was transferred from another hospital where an incision was performed for a suspected superinfected hematoma of the left thigh. Since the patient showed high leukocytosis and redness and swelling of the thigh, local debridement, drainage, and excisional biopsy of the tumor mass were performed in our unit in the emergency setting, and the tumor was taken for histopathology evaluation. Intraoperatively, the mass appeared nonspecific. The permanent histopathology report established a diagnosis of melanoma, with tumor proliferation also involving lymphoid tissue, and despite broad clinical and imagistic assessments, the primary melanoma could not be identified. Clinicians must be aware of the varied clinical manifestations of malignant melanoma, especially in cases of occult melanoma where the primary site is not evident.

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Metastatic malignant melanoma of unknown primary in temporalis muscle

Cited by 5 publications

References 12 publications

Melanoma of unknown primary with skeletal muscle metastasis. A case report

Melanoma of unknown primary with skeletal muscle metastasis. A case report

Melanoma of unknown primary origin with skeletal muscle metastasis: a case report

Comprehensive Literature Review on Melanoma of Unknown Primary Site Triggered by an Intriguing Case Report

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