Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature

Fèvre, C. Le; Vigneron, C.; Schuster, Hans-Peter; Walter, Axel; Marcellin, Luc; Massard, Gilbert; Lutz, Patrick; Noël, G.

doi:10.1016/j.canrad.2017.10.006

Cited by 8 publications

(5 citation statements)

References 54 publications

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“…Epithelial malignancies associated with germ cell tumours are mostly colonic-type adenocarcinoma (12). To date, only 21 patients with mediastinal mature teratomas that underwent malignant transformation into adenocarcinoma have been reported, five of whom had lymph node metastases (17). To the best of our knowledge, ours is the first report of the type of disease manifestation described herein, although apocrine…”

Section: Discussionmentioning

confidence: 63%

Primary Mediastinal HER2-positive Apocrine Carcinoma in Mature Teratoma Treated With Anti-HER2 Therapy and Chemoradiation

Sugiyama

Iwakoshi

Satoh

et al. 2019

In Vivo

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Background: There are no established guidelines for the management of apocrine carcinomas of the breast; they are treated as a non-specific type of breast cancer. Case Report: We report on the case of a 40-year-old man who developed primary mediastinal apocrine carcinoma overexpressing human epidermal growth factor-2 (HER2). The patient initially underwent complete resection of a mediastinal mature teratoma with a focal apocrine carcinoma component. Two years after surgery, relapse was detected in multiple mediastinal lymph nodes. He received induction chemotherapy including docetaxel, trastuzumab, and pertuzumab; consolidative concurrent chemoradiation was added after six cycles. A complete response was confirmed using computed tomography following this multimodal therapy. After chemoradiation, adjuvant trastuzumab and pertuzumab were administered for 1 year and the patient has since had no evidence of progressive disease. Conclusion: A multi-modal regimen that includes an anti-HER2 agent appears to be a promising treatment for patients with HER2positive extramammary apocrine carcinoma.Primary mediastinal tumours encompass a variety of histological types including thymoma/thymic cancer, germ cell tumours, cystic disease, neurogenic tumours, lymphoma, 551 This article is freely accessible online.

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Section: Discussionmentioning

confidence: 63%

Primary Mediastinal HER2-positive Apocrine Carcinoma in Mature Teratoma Treated With Anti-HER2 Therapy and Chemoradiation

Sugiyama

Iwakoshi

Satoh

et al. 2019

In Vivo

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“…In cases where surgery is possible, survival is similar to patients without malignant transformation, but is incurable in metastatic patients. 2,4…”

Section: Discussionmentioning

confidence: 99%

“…In this article, a patient with enteric adenocarcinoma on the basis of teratoma presenting with a mediastinal mass invading the sternum is presented. [1][2][3]…”

Section: Introductionmentioning

confidence: 99%

Enteric adenocarcinoma arising from mediastinal teratoma in a man: A case report

Fidan

Dağistan

Uzun

et al. 2021

Turkish Journal of Internal Medicine

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“…It can maximize the protection of bilateral phrenic nerves, pericardial phrenic vessels, innominate veins, etc. When the tumor is large and involves surrounding important organs or blood vessels, it is convenient to operate [11]. The disadvantage is that the surgical incision is long, the trauma is large, and the integrity of the thoracic cage is destroyed, the postoperative hospital stay is long, the recovery time is long, and it is di cult to be accepted by the patient [12].…”

Section: Discussionmentioning

confidence: 99%

Effects of Modified Subxiphoid Thoracoscopic Surgery and Traditional Surgery On Pain Mediators and Pain Stress Levels in Patients With Anterior Mediastinal Teratoma

Zhang

Liu

Luo

et al. 2021

Preprint

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Background To investigate the effects of modified subxiphoid thoracoscopic surgery and traditional surgery on pain mediators and pain stress levels in patients with anterior mediastinal teratoma. Method Eighty patients with anterior mediastinal teratoma who underwent surgery in our hospital from May 2019 to May 2021 were selected as the subjects of this prospective study. According to the random residue grouping method, they were divided into a control group and observation group with 40 cases each. Among them, the control group underwent traditional surgery, and the observation group underwent modified subxiphoid thoracoscopic surgery. Observe and compare the surgical indicators, pain-causing mediators, and pain stress levels of the two groups of patients. Result The intraoperative blood loss, postoperative extubation time, and total drainage volume of the observation group were significantly lower than those of the control group, while the operation time was significantly higher than that of the control group, which was statistically significant (P < 0.05). There was no statistically significant difference in the pain-causing mediators of the two groups before surgery (P > 0.05), while the NPY, PGE2 and 5-HT at 1 day after surgery were significantly different, and the observation group was better than the control group. The comparison was statistically significant. Significance (P < 0.05). There was no statistically significant difference in pain stress levels between the two groups before surgery (P > 0.05), while NO, IL-6, and IL-β 1 day after surgery were significantly different, and the observation group was better than the control group. Statistically significant (P < 0.05). Conclusion The modified subxiphoid thoracoscopic surgery has a significant effect, reduces the level of peripheral blood pain-causing factors, relieves the pain of the patient, and promotes the recovery of the patient. It provides a certain reference for the mediastinal teratoma before the clinical operation.

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Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature

Cited by 8 publications

References 54 publications

Primary Mediastinal HER2-positive Apocrine Carcinoma in Mature Teratoma Treated With Anti-HER2 Therapy and Chemoradiation

Primary Mediastinal HER2-positive Apocrine Carcinoma in Mature Teratoma Treated With Anti-HER2 Therapy and Chemoradiation

Enteric adenocarcinoma arising from mediastinal teratoma in a man: A case report

Effects of Modified Subxiphoid Thoracoscopic Surgery and Traditional Surgery On Pain Mediators and Pain Stress Levels in Patients With Anterior Mediastinal Teratoma

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