Metastatic Melanoma: A Preclinical Model Standardization and Development of a Chitosan-Coated Nanoemulsion Containing Temozolomide to Treat Brain Metastasis

Gelsleichter, Nicolly Espindola; Souza, Priscila Oliveira de; Teixeira, Fernanda Cardoso; Debom, Gabriela Nogueira; Lenz, Gabriela Spies; Roliano, Gabriela Gonçalves; Sant'ana, Rita de Cássia; Visioli, Fernanda; Fachel, Flávia Nathiely Silveira; Michels, Luana Roberta; Azambuja, Juliana H.; Teixeira, Hélder Ferreira; Braganhol, Elizandra

doi:10.1007/s10571-023-01338-4

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…Melanoma is the most aggressive type of skin cancer [ 82 ]. Although melanoma in the early stages of the disease is curable, the prognosis if it metastasises is very poor [ 83 ].…”

Section: Resultsmentioning

confidence: 99%

Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review

Rosochowicz,

Kulcenty,

Suchorska

2024

Mol Diagn Ther

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Purpose HtrA1 , HtrA2 , HtrA3 and HtrA4 appear to be involved in the development of pathologies such as cancer. This systematic review reports the results of a literature search performed to compare the expression of HtrA family genes and proteins in cancer versus non-cancer tissues and cell lines, assess relationships between HtrA expression and cancer clinical features in cancer, and analyse the molecular mechanism, by which HtrA family affects cancer. Methods The literature search was conducted according to the PRISMA statement among four databases (PubMed, Web of Science, Embase and Scopus). Results A total of 38 articles met the inclusion criteria and involved the expression of HtrA family members and concerned the effect of HtrA expression on cancer and metastasis development or on the factor that influences it. Additionally, 31 reports were retrieved manually. Most articles highlighted that HtrA1 and HtrA3 exhibited tumour suppressor activity, while HtrA2 was associated with tumour growth and metastasis. There were too few studies to clearly define the role of the HtrA4 protease in tumours. Conclusion Although the expression of serine proteases of the HtrA family was dependent on tumour type, stage and the presence of metastases, most articles indicated that HtrA1 and HtrA3 expression in tumours was downregulated compared with healthy tissue or cell lines. The expression of HtrA2 was completely study dependent. The limited number of studies on HtrA4 expression made it impossible to draw conclusions about differences in expression between healthy and tumour tissue. The conclusions drawn from the study suggest that HtrA1 and HtrA3 act as tumour suppressors. Supplementary Information The online version contains supplementary material available at 10.1007/s40291-024-00712-2.

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“…Melanoma is the most aggressive type of skin cancer [ 82 ]. Although melanoma in the early stages of the disease is curable, the prognosis if it metastasises is very poor [ 83 ].…”

Section: Resultsmentioning

confidence: 99%

Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review

Rosochowicz,

Kulcenty,

Suchorska

2024

Mol Diagn Ther

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“…A. sibirica -modified lipid nanoparticles are able to bypass the BBB via the non-invasive intranasal route [ 60 ]. Therefore, different routes for the delivery of TMZ to the CNS, using terpene-modified liposomes can be considered, thereby avoiding interference with first-pass metabolism [ 61 , 62 ]. In addition, inhibition of the inflammatory response and reduction in the risk of tumor recurrence can be achieved through adjuvant cancer therapy with abietic acid [ 63 , 64 ].…”

Section: Introductionmentioning

confidence: 99%

Terpenes-Modified Lipid Nanosystems for Temozolomide, Improving Cytotoxicity against Glioblastoma Human Cancer Cells In Vitro

Pashirova,

Nemtarev,

Buzyurova

et al. 2023

Nanomaterials

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Currently, increasing the efficiency of glioblastoma treatment is still an unsolved problem. In this study, a combination of promising approaches was proposed: (i) an application of nanotechnology approach to create a new terpene-modified lipid system (7% w/w), using soybean L-α-phosphatidylcholine, N-carbonyl-methoxypolyethylene glycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine for delivery of the chemotherapy drug, temozolomide (TMZ, 1 mg/mL); (ii) use of TMZ associated with natural compounds—terpenes (1% w/w) abietic acid and Abies sibirica Ledeb. resin (A. sibirica). Different concentrations and combinations of terpene–lipid systems were employed to treat human cancer cell lines T 98G (glioblastoma), M-Hela (carcinoma of the cervix) and human liver cell lines (Chang liver). The terpene–lipid systems appeared to be unilamellar and of spherical shape under transmission electron microscopy (TEM). The creation of a TMZ-loaded terpene–lipid nanosystem was about 100 nm in diameter with a negative surface charge found by dynamic light scattering. The 74% encapsulation efficiency allowed the release time of TMZ to be prolonged. The modification by terpenes of TMZ-loaded lipid nanoparticles improved by four times the cytotoxicity against human cancer T 98G cells and decreased the cytotoxicity against human normal liver cells. Terpene-modified delivery lipid systems are of potential interest as a combination therapy.

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Metastatic Melanoma: A Preclinical Model Standardization and Development of a Chitosan-Coated Nanoemulsion Containing Temozolomide to Treat Brain Metastasis

Cited by 2 publications

References 55 publications

Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review

Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review

Terpenes-Modified Lipid Nanosystems for Temozolomide, Improving Cytotoxicity against Glioblastoma Human Cancer Cells In Vitro

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