Metastatic melanoma to the small bowel causing intussusception: A case report

Kharroubi, Hussein; Osman, Bassam; Kakati, Rasha; Korman, Rawan; Khalife, Mohamad

doi:10.1016/j.ijscr.2022.106916

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…The tendency of metastatic melanoma to form a gastrointestinal mass that acts as lead point causing intussusception as been reported in few cases. The variable presentation of adult intussusception along with a low index of suspicion for the condition, given rarity, makes diagnosis challenging [41]. A study by Bender et al [42] revealed that the polypoid pattern is the most common manifestation of metastatic melanoma to the small bowel.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal metastatic melanoma: imaging findings and review of literature

Lo Mastro,

Grassi,

Reginelli

et al. 2024

J Med Imaging Intervent Radiol

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Melanoma represents approximately 5% of all the skin cancers and is well known for its ability to metastasize to a wide range of atypical locations. Organs most commonly affected by metastatic melanoma include liver, lung and brain, but spread to the gastrointestinal tract is not uncommon and small bowel involvement ranges from 51 to 71% of the cases. Given the nonspecific nature of the clinical presentation and the broad differential diagnosis, the prompt choice of imaging modality and its correct interpretation is important in order to perform a timely diagnosis. Early diagnosis and treatment of these lesions improve survival and quality of life, even in palliative cases. In this narrative review, we analyze the different imaging modalities used in the diagnosis of gastrointestinal metastases from melanoma. Typical radiological signs supporting the radiologists in interpreting images are also discussed.

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Section: Discussionmentioning

confidence: 99%

Gastrointestinal metastatic melanoma: imaging findings and review of literature

Lo Mastro,

Grassi,

Reginelli

et al. 2024

J Med Imaging Intervent Radiol

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“…A systematic review and meta-analysis by Hong et al showed that a metastatic carcinoma acted as a culprit in the majority of intussusception cases [9]. Known for its high metastatic potential, malignant melanoma has the tendency to metastasize to the gastrointestinal tract as the third most common site, with the small intestine commonly affected which is largely attributed to its rich blood supply [10][11][12]. Despite this, metastatic melanoma causing small bowel obstruction is relatively rare [3].…”

Section: Discussionmentioning

confidence: 99%

A Case of Jejuno-Jejunal Intussusception Caused by Underlying Metastatic Melanoma

Ahdi¹,

Kruchko²,

Asado³

et al. 2023

Cureus

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Intussusception in adults is a rare finding with a majority of cases occurring in the pediatric population. It occurs infrequently and its presentation, etiology, and treatment differ from childhood intussusception. When discovered in adults, it raises suspicion for a neoplastic process serving as the pathological lead point. Cross-sectional imaging is the primary study of choice for diagnosis, but at times, a more invasive approach involving an exploratory laparotomy is required posing an increased risk for morbidity and mortality. Here we present a 64-year-old male who was found to have jejunal-jejunal intussusception that was surgically removed with pathology revealing metastatic melanoma as the lead point. This case highlights a unique presentation of a melanoma that was previously eradicated with immunotherapy and now had metastasized to the intestine many years later.

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“…The spectrum of primary tumours includes adenocarcinoma, non-Hodgkin lymphoma, Kaposi's sarcoma in HIV patients [20] as well as sarcomas in otherwise healthy patients [21,22], gastrointestinal stromal tumours [23] and neuroendocrine tumours [24]. Common metastatic tumours are lung, breast, melanoma and sarcoma [25,26]. Other sites include renal cell carcinoma [27].…”

Section: Aetiology and Trajectorymentioning

confidence: 99%

Small bowel intussusception – aetiology & management

Sciberras,

Zammit,

Sidhu

2024

Current Opinion in Gastroenterology

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Purpose of review Adult small bowel intussusception (SBI) differs in incidence, symptomatology and management from the more commonly encountered paediatric intussusception. This review spans across the multitude of causes of adult SBI, and summarises the diagnostic work-up and management options according to recent literature. Recent findings There has been an increase in use of small bowel capsule endoscopy and point-of-care ultrasound for the diagnosis of acute adult SBI. Summary A high degree of suspicion of a malignant cause of SBI is required in the adult population. Alarm clinical features include weight loss, history of malignancy, and iron deficiency anaemia. CT remains the gold standard imaging technique as it may identify the lead point and thus aid in endoscopic or surgical management. If malignancy is excluded and no lead point is identified, serology and histology may be helpful to look for inflammatory, infective and autoimmune aetiology.

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Metastatic melanoma to the small bowel causing intussusception: A case report

Cited by 6 publications

References 17 publications

Gastrointestinal metastatic melanoma: imaging findings and review of literature

Gastrointestinal metastatic melanoma: imaging findings and review of literature

A Case of Jejuno-Jejunal Intussusception Caused by Underlying Metastatic Melanoma

Small bowel intussusception – aetiology & management

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