Metastatic Minor Salivary Gland Colloid Carcinoma in the Parotid Region After Parotidectomy for Pleomorphic Adenoma

Dharan, Muralee

doi:10.1159/000326105

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…The most common is mucoepidermoid carcinoma, which may produce copious extracellular mucin 1 . Other less common mucin‐producing tumours include colloid (mucinous) carcinoma (CC), mucinous cystadenocarcinoma (MCA), salivary duct carcinoma (SDC), signet ring cell carcinoma, adenocarcinoma (NOS), and occasionally a metastatic tumour 2–7 . Rarely, a benign pleomorphic adenoma or myoepithelioma may undergo prominent mucinous metaplasia 8 …”

Section: Introductionmentioning

confidence: 99%

Primary mucin‐producing tumours of the salivary glands: a clinicopathological and morphometric study

Yakirevich

Sabo

Klorin³

et al. 2010

Histopathology

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Section: Introductionmentioning

confidence: 99%

Primary mucin‐producing tumours of the salivary glands: a clinicopathological and morphometric study

Yakirevich

Sabo

Klorin³

et al. 2010

Histopathology

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“…Tumors with colloid architecture, defined by malignant cells floating in lakes of extracellular mucin, were recognized as a standalone entity under the name mucinous adenocarcinoma in the 2005 World Health Organization (WHO) Classification of Head and Neck Tumours. [1][2][3][4][5][6][7][8][9][10][11][12][13] Invasive tumors composed of papillary mucinous epithelium, alternately described as papillary cystadenocarcinomas or mucus-producing adenopapillary carcinomas, also were included as a significant component of the cystadenocarcinoma category in the 2005 WHO. [13][14][15][16][17][18][19] Signet ring carcinomas composed of discohesive cells with intracellular mucin vacuoles have also rarely been described.…”

mentioning

confidence: 99%

“…Historically, these tumors have largely been characterized in the literature in single case reports and small series, which divided them into several categories based on distinctive histologic patterns. Tumors with colloid architecture, defined by malignant cells floating in lakes of extracellular mucin, were recognized as a standalone entity under the name mucinous adenocarcinoma in the 2005 World Health Organization (WHO) Classification of Head and Neck Tumours 1–13. Invasive tumors composed of papillary mucinous epithelium, alternately described as papillary cystadenocarcinomas or mucus-producing adenopapillary carcinomas, also were included as a significant component of the cystadenocarcinoma category in the 2005 WHO 13–19.…”

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confidence: 99%

Salivary Mucinous Adenocarcinoma Is a Histologically Diverse Single Entity With Recurrent AKT1 E17K Mutations

Rooper

Argyris

Thompson

et al. 2021

American Journal of Surgical Pathology

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Mucin-producing salivary adenocarcinomas were historically divided into separate colloid carcinoma, papillary cystadenocarcinoma, and signet ring cell carcinoma diagnoses based on histologic pattern, but have recently been grouped together in the adenocarcinoma not otherwise specified category. It is currently unclear if these tumors represent 1 or more distinct entities and how they are related to well-circumscribed papillary mucinous lesions with recurrent AKT1 E17K mutations that were recently described as salivary intraductal papillary mucinous neoplasm. Here, we sought to evaluate the clinicopathologic and molecular features of salivary mucinous adenocarcinomas to clarify their classification. We identified 17 invasive mucin-producing salivary adenocarcinomas, 10 with a single histologic pattern, and 7 with mixed patterns. While most tumors demonstrated papillary growth (n=15), it was frequently intermixed with colloid (n=6) and signet ring (n=3) architecture with obvious transitions between patterns. All were cytokeratin 7 positive (100%) and cytokeratin 20 negative (0%). Next-generation sequencing performed on a subset demonstrated recurrent AKT1 E17K mutations in 8 cases (100%) and TP53 alterations in 7 cases (88%). Of 12 cases with clinical follow-up (median: 17 mo), 4 developed cervical lymph node metastases, all of which had colloid or signet ring components. Overall, overlapping histologic and immunohistochemical features coupled with recurrent AKT1 E17K mutations across patterns suggests that mucin-producing salivary adenocarcinomas represent a histologically diverse single entity that is closely related to tumors described as salivary intraductal papillary mucinous neoplasm. We propose a unified mucinous adenocarcinoma category subdivided into papillary, colloid, signet ring, and mixed subtypes to facilitate better recognition and classification of these tumors.

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Salivary Glands

Gnepp¹,

Skálová²,

Palma³

et al. 2021

Gnepp's Diagnostic Surgical Pathology of the Head and Neck

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Metastatic Minor Salivary Gland Colloid Carcinoma in the Parotid Region After Parotidectomy for Pleomorphic Adenoma

Cited by 5 publications

References 12 publications

Primary mucin‐producing tumours of the salivary glands: a clinicopathological and morphometric study

Primary mucin‐producing tumours of the salivary glands: a clinicopathological and morphometric study

Salivary Mucinous Adenocarcinoma Is a Histologically Diverse Single Entity With Recurrent AKT1 E17K Mutations

Salivary Glands

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