Metastatic MSSA infection of the spine and extremities

Katsuura, Yoshihiro; Cincere, Brandon; Cason, Garrick W.; Osborn, James

doi:10.1136/bcr-2017-222778

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…However, all symptom management experienced if their caregivers do not have any experience or care information; it is a risk for care burdensome and emotional change. The physical changes as a result of caregivers caring for persons with MSC influence the physiological, psychological, socio-economic, and spiritual well-being of patients and their families [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The experiences and needs of metastatic spinal cancer family caregivers at home: a systematic review

Kardosod

Needham

Coyne

2023

Support Care Cancer

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Purpose Family caregivers have high responsibilities for caring for persons with metastatic spinal cancer; however, understanding the experiences and needs of family caregivers face to overall recent, what is nurse-led could support them to meet their needs appropriately? Thus, the study aimed to review the experiences and needs of metastatic spinal cancer caregivers at home in the past decades. Methods A qualitative systematic review of 8 studies was undertaken. Analysed studies were conducted in different countries (Australia, Cyprus, Italy, Kenya, Pakistan, Thailand, and Turkey), covering a population of 92 caregivers. Thematic analysis was applied to identify family caregiver experiences and needs. Results Thematic analysis identified four key themes from the included studies: (1) complexity of needs, (2) caregivers’ role and physical needs, (3) complexity of psychosocial needs, and (4) understanding supportive care. Conclusions The results across 8 different countries indicate that family caregivers of metastatic spinal cancer commonly face diverse challenges in many diverse geographical contexts across cultures, requiring biomedical, practical, physical, and psychosocial support from healthcare systems within the matrix of broader challenges and resources available to improve supportive care for such service users.

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Section: Introductionmentioning

confidence: 99%

The experiences and needs of metastatic spinal cancer family caregivers at home: a systematic review

Kardosod

Needham

Coyne

2023

Support Care Cancer

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“…The rise of antimicrobial resistant (AMR) bacterial infections is one of the most pressing issues in medicine. Increasingly, conventional antibiotic medications are failing to stop persistent and dangerous bacterial diseases (Irenji et al, 2018; Katsuura et al, 2018). A report commissioned by the UK government notes that roughly 700,000 people die annually from AMR infections; this figure is projected to increase to 10 million deaths per year by 2050 (O’Neil, 2016) and encompasses data from across the broad spectrum of pathogenic microbes.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Kalanchoe mortagei and K. fedtschenkoi Against ESKAPE Pathogens

et al. 2019

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Plants in the genus Kalanchoe (Family: Crassulaceae) are used in traditional medicine throughout the tropics for treating a variety of conditions. Two species, Kalanchoe mortagei and K. fedtschenkoi, have established ethnobotanical usage but have been neglected in previous research concerning their potential bioactivity. Here, we provide a thorough review of the reported antimicrobial activities of Kalanchoe genus and evaluate the in vitro antibacterial effects of two previously unexplored species against a panel of multidrug-resistant bacteria, the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter cloacae). Plant specimens were collected and voucher specimens deposited in the Emory University Herbarium. Dried plant material was ground into a powder and extracted as ethanolic macerations or as aqueous decoctions. Extracts were tested against the ESKAPE pathogens for growth inhibitory activity. Cytotoxicity to human cells was assessed via a lactate dehydrogenase assay of treated human keratinocytes (HaCaTs). K. fedtschenkoi extracts demonstrated growth inhibitory effects against two Gram-negative species, A. baumannii (strain CDC-33) and P. aeruginosa (AH-71), as well as S. aureus (UAMS-1). In these cases, growth inhibition greater than 50% (IC50) was generally observed at concentrations of 256 μg mL-1, though one K. fedtschenkoi extract (1465, prepared from stems) exhibited an IC50 against A. baumannii at 128 μg mL-1. All extracts were well tolerated by HaCaTs (LD50 ≥ 256 μg mL-1). Chemical characterization using HPLC and chemical standards established the presence of caffeic acid and quercetin in both plant species, as well as kaempferol in K. fedtschenkoi. These results reveal K. fedtschenkoi to be a plant of medicinal interest, and future research should aim to characterize the bioactivity of this species and its active constituents through bioassay-guide fractionation. Effects on bacterial biofilm formation and quorum-sensing are also research topics of interest for this genus.

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“…For example, T 2 -weighted MRI can be used to differentiate between benign and malignant inflammatory breast lesions (12). In addition, T 2 -weighted MRI can help identify the presence of bacterial infections arising from methicillin-sensitive Staphylococcus aureus (13) or viral infections such as Zika and Cytomegalovirus (14–15). A temporal series of dynamic contrast enhanced (DCE) magnetic resonance (MR) images can be used to measure transport rate constants and identify inflammation caused by atherosclerotic plaques (16–19).…”

Section: Introductionmentioning

confidence: 99%

Differentiation of Myositis-Induced Models of Bacterial Infection and Inflammation with T2-Weighted, CEST, and DCE-MRI

et al. 2019

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We used T2 relaxation, chemical exchange saturation transfer (CEST), and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to assess whether bacterial infection can be differentiated from inflammation in a myositis-induced mouse model. We measured the T2 relaxation time constants, %CEST at 5 saturation frequencies, and area under the curve (AUC) from DCE-MRI after maltose injection from infected, inflamed, and normal muscle tissue models. We applied principal component analysis (PCA) to reduce dimensionality of entire CEST spectra and DCE signal evolutions, which were analyzed using standard classification methods. We extracted features from dimensional reduction as predictors for machine learning classifier algorithms. Normal, inflamed, and infected tissues were evaluated with H&E and gram-staining histological studies, and bacterial-burden studies. The T2 relaxation time constants and AUC of DCE-MRI after injection of maltose differentiated infected, inflamed, and normal tissues. %CEST amplitudes at −1.6 and −3.5 ppm differentiated infected tissues from other tissues, but these did not differentiate inflamed tissue from normal tissue. %CEST amplitudes at 3.5, 3.0, and 2.5 ppm, AUC of DCE-MRI for shorter time periods, and relative Ktrans and kep values from DCE-MRI could not differentiate tissues. PCA and machine learning of CEST-MRI and DCE-MRI did not improve tissue classifications relative to traditional analysis methods. Similarly, PCA and machine learning did not further improve tissue classifications relative to T2 MRI. Therefore, future MRI studies of infection models should focus on T2-weighted MRI and analysis of T2 relaxation times.

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Metastatic MSSA infection of the spine and extremities

Cited by 3 publications

References 15 publications

The experiences and needs of metastatic spinal cancer family caregivers at home: a systematic review

The experiences and needs of metastatic spinal cancer family caregivers at home: a systematic review

Antibacterial Activity of Kalanchoe mortagei and K. fedtschenkoi Against ESKAPE Pathogens

Differentiation of Myositis-Induced Models of Bacterial Infection and Inflammation with T2-Weighted, CEST, and DCE-MRI

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